Nystagmus series – Part VII
(seesaw & hemi-seesaw nystagmus)

“Maddox rod, double prism Maddox, red glass Maddox, Maddox cross, and Maddox wing”

British ophthalmologist Ernest Edmund Maddox (1863–1933)
(first report)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/ Image
Definition

“one half-cycle of elevation&intorsion of one eye
and
synchronous depression&extorsion of the other eye.
Next half-cycle,
vertical&torsional components are reversed”

- waveform: pendular (seesaw) & jerk (hemi-seesaw)
- hemi-seesaw: only one half-cycle

2/ Image
Pathophysiology

Jerk (hemi-seesaw)
- lesion in the interstitial nucleus of Cajal

Pendular (seesaw)
- parasellar (midbrain compression & visual field defects)
- calibration lesion

3/ Image
Fixation

Fixation in central vestibular nystagmus

“poorly suppressed by fixation of a visual target”

- abnormal smooth-pursuit system


4/
Associated symptoms

Hemi-seesaw nystagmus
- contralateral ocular tilt reaction
- central otolithic imbalance

Seesaw nystagmus
- visual field defect

5/ Image
Considerations

Reversed congenital form
- elevation & extorsion
- dissociated vertical deviation

6/
Seesaw nystagmus – features

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

7/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

via: Moran CORE

8/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

via: Moran CORE

9/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

via: Frederico Moura

10/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

via: Raed Behbehani

11/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

via: Lisa Koch

12/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

via: Audiology-Vestibular Science Academy

13/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

youtube.com/shorts/oyuTlHw… via: Dr Pawan Prasher

14/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

via: Neuroftalmologia em Foco

15/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

via: Raed Behbehani

16/
Seesaw nystagmus

i) 🔄 elevation&intorsion w/ depression&extorsion
ii) no suppress by visual fixation

via: Dr Gamal Sobhy

17/
Hemi-seesaw nystagmus – features

i) elevation&intorsion w/ depression&extorsion
ii) only one half-cycle
iii) no suppress by visual fixation

18/
Hemi-seesaw nystagmus

i) elevation&intorsion w/ depression&extorsion
ii) only one half-cycle
iii) no suppress by visual fixation

doi.org/10.1017/cjn.20… via: Canadian Journal of Neurological Sciences

19/
Hemi-seesaw nystagmus

i) elevation&intorsion w/ depression&extorsion
ii) only one half-cycle
iii) no suppress by visual fixation

doi.org/10.1212/WNL.0b… via: Neurology

20/
Hemi-seesaw nystagmus

i) elevation&intorsion w/ depression&extorsion
ii) only one half-cycle
iii) no suppress by visual fixation

doi.org/10.1007/s00415… via: Journal of Neurology

21/
Hemi-seesaw nystagmus

i) elevation&intorsion w/ depression&extorsion
ii) only one half-cycle
iii) no suppress by visual fixation

doi.org/10.1016/j.jocn… via: Journal of Clinical Neuroscience

22/
Nystagmus general description

"Nystagmus – Moving eyes!!!"

23/

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More from @theneurolander

Nov 29
Wing-beating tremor!!!

“pseudosclerotic, parkinsonism, and dystonic/choreic forms of Wilson’s disease”

American-born British neurologist Samuel Alexander Kinnier Wilson (1878–1937)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/ Image
Pathophysiology

“lesion in the dentatorubrothalamic pathway”

- cerebellar outflow pathway

Complex phenomenology
- dystonic, myoclonic, rhythmic tremor?


2/
Definition

“low-frequency, high-amplitude, posture-induced proximal arm tremor, elicited by sustained abduction of the arms, with flexed elbows and palms facing downward”

- postural tremor
- wing-beating posture

3/ Image
Read 21 tweets
Nov 25
Head retraction reflex!!!

“the great neurologist and neurosurgeon from Breslau (Wrocław)”

German neurologist and neurosurgeon Otfrid Foerster (1873–1941)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/ Image
History

Head retraction reflex is a “triphasic cutaneomuscular reflex” related to the trigeminal system with some pyramidal control.

2/ Image
Features

“reflex hammer tap below nose with head bent forward cause backward jerk of the head”

- considered a frontal release sign
- hyperreflexia
- triphasic cutaneomuscular reflex

3/ Image
Read 13 tweets
Nov 23
Corneomandibular reflex!!!

“there is hardly a more valuable test than this to uncover a supranuclear lesion of the trigeminal nerve”

Russian neurologist Robert Wartenberg (1887–1956)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/
History

1902 by German doctor Von Sölder
- first description, normal patients

1918 by German neurologist Ernst Trömner
- rediscovered the reflex

1948 by Russian neurologist Robert Wartenberg
- complete description
- ‘jaw wincking phenomenon’

2/
Pathophysiology

Mesencephalic trigeminal nucleus
- there is an inhibitory interneuron ipsilateral motor nucleus of V CN

Lesions in cortico-pontine boundaries lesions
- inhibitory influence disappear
- massive activation of trigeminal motor neuron

doi.org/10.4103%2F0976…

3/
Read 9 tweets
Nov 23
Movement disorders specialists, I would appreciate your opinion.
A patient sent me this video.
I found the movements too quick and too high amplitude to be polyminimyoclonus.
What are your opinions about this movement?
@AlbertoEspay @SanjayP30043502 @AbhiLenka11 @JackyGanguly
MYBPC1 mutation are associated with myogenic tremor and mild myopathy

doi.org/10.1002/ana.25…
MYBPC1 mutation are associated with myogenic tremor and mild myopathy

doi.org/10.1002/ana.25…
Read 5 tweets
Nov 23
Nystagmus series – Part VI
(periodic alternating nystagmus, PAN)

“Nystagmus processor for EEG machines”

Italian-American neurologist Joseph Toglia (1927 – 2018)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials @TempleUniv

1/ Image
Definition

“horizontal nystagmus reverses direction every 2 minutes”

During transition period
-upbeating, downbeating, square-wave jerks can occur

- acquired form is rare, but it is the best understood and the first to have effective treatment

2/ Image
Pathophysiology

“lesion in cerebellum nodulus & uvula”

nodulus & uvula
- responsible for velocity-storage mechanism
- inhibitory control on vestibular rotation using GABA (baclofen-responsive)

vestibular system
- repair mechanism
- reverse direction of nystagmus

3/ Image
Read 21 tweets
Nov 21
Eye of the Tiger Sign

Clinical Correlate: Neurodegeneration With Brain Iron Accumulation Type 1

2/ Mulroy E, Balint B, Adams M...
Face of the Panda Sign

Clinical Correlate: Wilson's Disease

3/ Mulroy E, Balint B, Adams M...
Read 35 tweets

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