‘I’m just carrying on’: vaccine gives brain cancer patient years of extra life
The revolutionary DCVax-L vaccine has allowed Nigel French to live a normal life seven years after a brain cancer diagnosis #DCVaxL $NWBO #CancerVaccine#Glioblastoma#Phase3
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma $NWBO #DCVaxL#CancerVaccine#GBM
A Phase 3 Prospective Externally Controlled Cohort Trial
More long-term Survivors, $NWBO #DCVaxL a personalized general therapeutic #CancerVaccine to treat any kind of solid tumor cancer anywhere in the body.
Other $NWBO investors, I think you'll find this book well worth reading or listening to... It's totally on point, #DCVaxL#CancerVaccine. @DrSidMukherjee
@matthwilliams@NWBIO@braintumourrsch@BrainTumourOrg Dude, your conflict of interest is all over you and this criticism. Let the regulators do their jobs. You focus on your patients and BUSINESS interests. Let the regulators, patients and market decide what they would prefer. You’re disgracing yourself in the field.
@matthwilliams@NWBIO@braintumourrsch@BrainTumourOrg Let's recall that Optune costs £20,000 per month in the UK, or £240,000 per year, as long as the patient lives, an incredibly expensive treatment, which is why the NHS only covers it for a limited group of patients. It's burdensome, expensive & requires 18 hrs a day compliance.
I can see why you'd prefer such an expensive treatment, forever, over a treatment that could make potentiatlly he same number of patients free from treatment at all.
Background: Standard of care (SOC) and patient survival in glioblastoma have changed little in the past 17 years.
We evaluated in a phase 3 trial whether adding an autologous tumor lysate-loaded dendritic cell vaccine (murcidencel) to SOC extends survival. Patients and
Methods: Newly diagnosed glioblastoma patients were randomized 2:1 to either murcidencel or placebo.
Under a crossover design, all patients could receive murcidencel following tumor recurrence. All parties remained blinded regarding treatments before recurrence. Patients thus received murcidencel at new diagnosis (nGBM) or at recurrence (rGBM) following crossover from placebo.
“The development, regulatory review and regulatory approval of a PIP is a pre-requisite for application for approval of a new medicine for adult patients, such as DCVax®-L.”
“The Company submitted its proposed PIP to the MHRA in February 2022, and has been going through the regulatory review process since then. On August 17, the Company received final approval of the PIP from the MHRA.”
1/ "Only 5% of glio patients survive for five years. So how stunning is it for DCVAX-L to see life expectancy at 60 months rise from 5.7% to 13%, an increase of 228%. Some patients have seen total remission glio and are cancer free more than a decade after treatment.
2/ For example, Brad Silver participated in the Phase 1 trial 17 years ago and is cancer free now."