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Anthony J Leonardi, PhD, MS Profile picture
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Dec 1 • 5 tweets • 3 min read
Kids with RSV were more likely to have had Covid!

Evidence of the #leonardiEffect at work, @DavidJoffe64!!

Thanks @ariccio

People like Rasmussen said it wouldn’t exist!!
Earlier I presented the elaboration of the hypothesis to include the hit to plasmacytoid dendritic cells and their interferon alpha production following mild covid, which would reduce resistance to infection with rsv
It looks like I was right! Hits to the immune system from covid are opening the door to outbreaks from and susceptibility to other viruses! This is me taking a bow! 🙌
There are confounders that could go either way but this is a great piece of evidence! For example, kids with more exposure would be more likely to be exposed to both viruses. Also this confounder below, conversely👇

But these can be controlled for!
Check out this new preprint @sciencecohen

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More from @fitterhappierAJ

Anthony J Leonardi, PhD, MS Profile picture
Dec 1
I'm ready to address a major criticism of myself

One of my greatest criticisms has been that I have conflated the T cell results in what happens in a small percentage of people in severe acute Covid with the broader experience of mild and moderate Covid
For example, I have maintained that covid rapidly ages T cells many times. This is separate to Lymphopenia, although they may co-exist. This is the T cell phenotype itself.

Yesterday, I asked if someone agreed with their previous assessment that Covid ages T cells worse than HIV

(This is not lymphopenia. Stop conflating it, pharmacists)
Image
Read 11 tweets
Anthony J Leonardi, PhD, MS Profile picture
Nov 29
You should read the paper you are calling acute.

These are recovered individuals at 2-3 months.
You are calling people convalescent and recovered "acute severe?"

I am afraid you have posted two pieces of misinformation
Looks like only 2 patients out of 55 were severe as well.
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Nov 29
Dr. Unutmaz is trying to claim the naive compartment reconstitutes. It is unlikely to do so without the proliferation of Naive cells.

At that point they are no longer Naive, but are Tscm

He is conflating the two
When people are reinfected they will continue to get acute covid

And these blood phenotypes are not only acute severe, and vaccination has not halted the T cell hyperactivation
So he claimed i conflated acute and chronic covid and blocked me

People are being reinfected and covid broadly stimulates

There is chronic spike in the blood of Long Covid patients

Yes, it will cause Naive T cell turnover
Read 4 tweets
Anthony J Leonardi, PhD, MS Profile picture
Nov 25
Well, looks like they are acknowledging the immunological harm that SARS Cov 2 does

I told you all long ago, many times, and have been mocked, abused, and cancelled for it
I told you all it phenotypically and epigenetically ages the cells
I told you all who would show decompensation. The elderly like people in the Wash U study. Compensation in the younger like the Qatar study

Read 5 tweets
Anthony J Leonardi, PhD, MS Profile picture
Nov 24
The virologists and immunologist disputing my claims rely on the public's inability to assess primary information

My verified claims have been:
1) There is no herd immunity to cov2
2) T cell memory is insufficient to control cov2
3) Reinfections can be severe or even lethal, with increased risk with low naive T cells
4) The virus is intrinsically severe (not like a cold on reinfection)
5) T cells age and undergo excessive effector differentiation from cov2
6) Cov2 harms immunity and immune memory
7) T cells initiate exhaustion programs from cov2
They initiate exhaustion programs for two reasons:
a) Hyperactivation
b) Chronic stimulation
Read 6 tweets
Anthony J Leonardi, PhD, MS Profile picture
Nov 22
The "T cell exhaustion" aspect of covid is not the most pressing issue

The most pressing issue are the broadly activated and therefore missing Tn cells in Long Covid

If activation and sloughing persists past those 8 months, you can start missing T cells
Image
I think people constantly bring up T cell exhaustion and try to attack me about it because they are trying to distract from this problem (that I anticipated was an issue)
The T cell exhaustion narrative requires lab work. I said it would happen if you kept getting reinfected and it was seen in Long Covid. My job with it is done. I can not carry it further past the aggregated multi-million dollar analyses that have been done on it already.
Read 6 tweets

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