Rabbit syndrome!!!

“a peculiar extrapyramidal reaction”

Canadian psychiatrist André Villeneuve
1972, the first report

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/
Definition

“stereotyped vertical, rhythmic movements, similar to the chewing movements of a rabbit”

5 Hz
Lips produce a popping sound
Not tardive dyskinesia!
- persist stage I sleep

2/
Pathophysiology

- cholinergic system?

3/
Clinical tips
dyskinesia versus rabbit syndrome

i) tongue 10s extruded
- dyskinesia, tongue twist
- rabbit, no movement

ii) lips movement
- only vertical, rabbit syndrome
- all directions, dyskinesia

iii) movement pace
- fast & rhythmic, rabbit
- slower & irreg, dyskinesia

4/
Management

Long-term antipsychotic use, begins a few days after modification in psych treatment

Disappear after antipsychotic discontinuation

- anti-Parkinson's drugs, some

5/
Rabbit syndrome

💡after risperidone withdrawal

via: Medtext Publications

6/
Rabbit syndrome

💡amisulpride-induced

via: Srinivasa Teja

7/
Rabbit syndrome

💡paliperidone discontinuation

doi.org/10.1097/jcp.0b… via: J Clin Psychopharmacol

8/
Rabbit syndrome

💡functional

doi.org/10.5334%2Ftohm… via: Tremor Other Hyperkinet Mov (N Y)

9/
Differ

perioral & pharyngeal myorhythmia
- lower freq (1-4 Hz), when compared to rabbit syndrome

doi.org/10.1016/j.park… via: Parkinsonism Relat Disord

10/
Differ

tardive dyskinesia
- 🔄& irregular

via: Bác Sĩ Thần Kinh

11/
Differ

perioral myorhythmia
- lower freq (1-4 Hz), when compared to rabbit syndrome

💡 medullary compression by vertebral artery

doi.org/10.1007/s10072… via: Neurol Sci

12/
Differ

perioral myorhythmia
- lower freq (1-4 Hz), when compared to rabbit syndrome

💡EMG should be performed

doi.org/10.4103%2Faian… via: Ann Indian Acad Neurol

13/
NeuroTeach - Content

The blog contains all the threads and videos.

neuronland.blogspot.com/2022/11/neurot…

Have a great day!
Differ

hereditary chin trembling (geniospasm)

💡childhood
💡improve w/ aging
💡botox-sensitive

doi.org/10.1212/WNL.00… via: Neurology @sdo_henrique

14/

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More from @theneurolander

Dec 5
Belly Dancer's Dyskinesia!!!

“first described by Antonie van Leeuwenhoek in 1723 when he himself experienced the symptoms”

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/
Definition

“rhythmic, involuntary contractions of the diaphragm resulting in undulating, rhythmic movements of the abdomen resembling a belly dance”

-bilateral, most freq
-limited to axial musculature
-sometimes painful
-no suppress on breath holding
-150 contraction/min

2/
History

1723, Leeuwenhoek
- 1st report
- diaphragmatic flutter

1976, Nichols
- 1st report
- abdominal wall dyskinesia
- phrenic palsy in a newborn

1990, Iliceto
≠ diaphragmatic flutter

3/
Read 26 tweets
Dec 2
Jack-in-the-box tongue!!!

“The English Hippocrates”

English physician Thomas Sydenham (1624 – 1689)
discovered Sydenham's chorea

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/
Pathophysiology

“combination of chorea & motor impersistence”



2/
Definition

“unable to maintain tongue in protruded state and the tongue moves in and out”

3/
Read 20 tweets
Dec 1
Milkmaid’s grip!!!

“motor impersistence of the hand”

Philippus Aureolus Theophrastus Paracelsus Bombastus von Hohenheim (1493–1541)
(Paracelsus)
first coined the term Chorea Sancti Viti

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/
Pathophysiology

“combination of chorea & motor impersistence”

Motor impersistence
- inability to maintain tetanic muscle contraction
- positioning & compensatory repositioning
- independent of chorea
- linearly progressive (marker of disease severity?)
- frontal lobe

2/
Examples of motor impersistence

- Milkmaid’s grip
- inability to maintain eye closure
- ‘Jack in the box’ tongue

3/
Read 19 tweets
Nov 30
Glabellar reflex (Myerson's sign)!!!

"the preliminary note on a new cranial reflex"

British doctor Walker Overend (1858–1926)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/ Image
Glossary

Glabellar reflex
Habituation
Myerson’s sign
Primitive reflex

2/ Image
History

1896, Dr. Walker Overend
- first report

1901, Dr. Daniel J. McCarthy
- published a 2nd report without acknowledging Overend

1944, Dr. Abraham Myerson
- observed, mainly, in PD

1954, Dr. Doshay
- called Myerson’s sign

3/ Image
Read 16 tweets
Nov 29
Wing-beating tremor!!!

“pseudosclerotic, parkinsonism, and dystonic/choreic forms of Wilson’s disease”

American-born British neurologist Samuel Alexander Kinnier Wilson (1878–1937)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/
Pathophysiology

“lesion in the dentatorubrothalamic pathway”

- cerebellar outflow pathway

Complex phenomenology
- dystonic, myoclonic, rhythmic tremor?


2/
Definition

“low-frequency, high-amplitude, posture-induced proximal arm tremor, elicited by sustained abduction of the arms, with flexed elbows and palms facing downward”

- postural tremor
- wing-beating posture

3/
Read 21 tweets
Nov 28
Nystagmus series – Part VII
(seesaw & hemi-seesaw nystagmus)

“Maddox rod, double prism Maddox, red glass Maddox, Maddox cross, and Maddox wing”

British ophthalmologist Ernest Edmund Maddox (1863–1933)
(first report)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/ Image
Definition

“one half-cycle of elevation&intorsion of one eye
and
synchronous depression&extorsion of the other eye.
Next half-cycle,
vertical&torsional components are reversed”

- waveform: pendular (seesaw) & jerk (hemi-seesaw)
- hemi-seesaw: only one half-cycle

2/ Image
Pathophysiology

Jerk (hemi-seesaw)
- lesion in the interstitial nucleus of Cajal

Pendular (seesaw)
- parasellar (midbrain compression & visual field defects)
- calibration lesion

3/ Image
Read 23 tweets

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