Toilets, wastewater COVID-19, RSV, and Influenza all increasing
This thread will be wastewater related, looking at new variants, levels, and what happens in the air after you flush that wastewater down the toilet with some cool video/graphics. 🧵1/
The wastewater levels in Ottawa, Canada are increasing for all measures ( ). RSV and Influenza A levels continue to increase which means even more pressure will be put on the hospitals that are already overwhelmed. 2/ covid.gilchrist.ca/Ottawa.html
To make matters worse, COVID-19 levels have started increasing again. You can see in the graph that levels never actually returned to low levels but are on the rise again ( ). 3/ covid.gilchrist.ca/Ottawa.html
What might be making the difference now? New Omicron BQ based variants have rapidly been increasing in Ontario and as of 10 days ago already made up more than 40% of sequenced cases ( ). Graphs by @Mike_Honey_ 4/ app.powerbi.com/view?r=eyJrIjo…
The BQ.1 Typhon and BQ.1.1 Cerberus variants specifically have overtaken all the other circulating variants in Ontario and are much more immune evasive than previous variants. 5/
If wastewater levels are going up again it could be because more people are susceptible to this newer variant and is being more easily transmitted amongst people, even those that have been previously infected. 6/
Speaking of wastewater, a very cool study used lasers to actually see and measure the aerosol plumes that come out of toilets when you flush ( ). H/T: @yaneerbaryam 7/ nature.com/articles/s4159…
Aerosols can transmit infectious diseases including COVID-19, influenza and likely most respiratory viruses and even Strep bacteria has airborne spread ( ). H/T: @ELHopkins 8/thelancet.com/journals/lanmi…
When you flush a toilet, it releases plumes of tiny water aerosols into the air around you which can spread pathogens from human waste and expose people in public washrooms to contagious disease ( ). 9/ theconversation.com/toilets-spew-i…
A typical commercial toilet generates a strong upward jet of air with velocities exceeding 2m/sec rapidly carrying particles up to 1.5m (5 feet) above the bowl within 8 seconds of the start of the flush which you can see in this video ( ). 10/
Toilet bowl water contaminated by feces can have pathogen concentrations that persist after dozens of flushes but it is still an open question as to how much of a transmission risk toilet aerosol plumes present. 11/
Particle size matters, the smaller aerosols can stay floating in the air for sometimes hours. Particles smaller than 5 microns can be breathed directly into your lower respiratory tract and those 6-12 microns can deposit in the upper airways ( ). 12/thelancet.com/journals/lanre…
The study measured a massive increase in particles smaller than 2.5 microns with most particles being less than 1 micron. 13/
Over the bowl (Loc 1 and 2 in diagram) particle counts increased more than 10x pre-flush rates and decreased afterwards, while 1.5m away from the bowl the particle count increase was lower but remained constant after flushing ( ). 14/ nature.com/articles/s4159…
While the visible aerosols in the video (5-10 microns) scatter more light from the lasers, they also captured the dimmer light scattered by smaller aerosols which found they move within the same envelope as the larger ones ( ). 15/ nature.com/articles/s4159…
Most interesting is they show large droplets follow ballistic trajectories, remain outside the aerosol plume envelope and drop quickly. Yet another blow to droplet theory being a significant contributor to transmission <darn laws of physics>. 16/
Closing the lid before flushing helps but does not completely eliminate plumes as there are still large gaps of space between the lid and the bowl when closed and many commercial toilets do not have lids at all. 17/
The researchers suggest that UV disinfection systems and better ventilation could help mitigate exposure to aerosol plumes in the bathroom. The next time you visit a public washroom, think of all the aerosolized human waste you are breathing in if you aren't wearing a mask... 18/
A lot of people have been saying to close the toilet lid first which doesn't stop the aerosols coming out and contaminates the underside of the lid that people touch as pointed out by this comment ( ). 19/
As @rnaguru points out, each pathogen is different, and so far studies haven't found much infectious COVID-19 particles in urine or feces so while the risk is not zero it may be very low. This may not be the case for other viruses/pathogens though ( ). 20/
But you will still want to wear your mask in public bathrooms to at least protect yourself from respiratory aerosols from the other people using the bathroom who may be infected (COVID, RSV, Influenza, etc...). 21/
It is not just breathing in aerosols released from flushing toilets that people need to worry about, but bacteria that gets deposited on your hands from hot-air hand dryers ( ). 22/ cnbc.com/2022/12/19/how…
A study before the pandemic found that test plates exposed to bathroom air for 2 minutes with hand dryers off averaged < 1 bacteria colony while plates exposed to hand dryer air for 30 seconds averaged 18-60 colonies ( ). 23/journals.asm.org/doi/10.1128/AE…
When researchers swabbed the interior hand dryer nozzle, they found surfaces had minimal bacterial levels so they added HEPA filters to the hand dryers which reduced bacterial deposition by 4x. 24/
This implies the bacteria was coming from the bathroom air so just after washing your hands you get pathogens deposited on them right after again. 25/
Health experts recommended using paper towels to dry their hands instead and remind everyone that acquiring infection from direct contact with other people is much more likely than from drying your hands. 26/
This study found during contact tracing that someone got infected after using a shared bathroom 40 minutes after the index case left. A good example of it isn't just the people currently there in a public bathroom you need to worry about ( … ). 27/icjournal.org/DOIx.php?id=10…
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People are rightfully concerned about the high case fatality rate (CFR) of the H5N1 influenza virus but did you know fatalities from COVID infection (which already spreads easily between humans) with the elderly are as high as 40% ( )? 🧵1/
Virus infection can damage the body, we have seen this with Long COVID and this can happen with other viruses as well such as Influenza causing increased risk of cardiovascular events among other things. 2/
This study tries to indirectly measure the impact of influenza infection by looking at cardiovascular events and then measuring the risk people had if they received the influenza vaccine or not( … ). 3/ H/T: @JaninePaynterncbi.nlm.nih.gov/pmc/articles/P…
#Variant update for #Ontario, #Canada (to Apr. 17, 2024)
The JN.1.* +FLiRT variants now make up 20% of sequences and XDK.* which is recombinant of JN.1.1.1 and XBB.1.16.11 has made an appearance at 5%. Graph tools by @Mike_Honey_ 🧵1/
FLiRT is a nickname for variants with F456L & R356T mutations which seem to provide an advantage over the JN.1 Pirola variants without them. You can see the current FLiRT variants here from @dfocosi. 2/
JN.1 #Pirola has dropped to around 20% frequency and JN.1.4 is hovering at 14% while the FLiRTs are gaining: KS.1 at 10%, KP.1.1 at 4%, KP.2 at 3% and XDK.1 at 4%. 3/
#Variant update for #Ontario, #Canada (to Apr. 9, 2024)
The regular BA.2.86.*/JN.1.* #Pirola clan of variants as you know them are starting to go down in Ontario. This is because descendants are picking up two very useful FLiRT mutations. Graph tools by @Mike_Honey_ 🧵1/
FLiRT is a nickname for variants with F456L & R356T mutations which seem to provide an advantage over the JN.1 Pirola variants without them. You can see the current FLiRT variants here from @dfocosi. 2/
Now that most variants with FLiRT have designations, you can see that JN.1 has dropped to 20% frequency while the new KP.3 FLiRT has jumped to 17.5%. The KS.1 FLiRT variant has also increased to 11% and KP.2 FLiRT is in the mix as well. 3/
PHO is reminding HCWs, even those who have been vaccinated, to wear an N95 while providing care to people with confirmed or suspected cases because they know N95s can prevent infection from infectious aerosols. Works for other airborne viruses as well and non-HCW too.
Respirators protect individuals who are healthy and help reduce the chance of individuals who are sick from infecting others even in well ventilated places where short-range transmission is a concern. 2/
Yes, respirators actually work, read this thread to learn how ( ). 3/
COVID-19 #Wastewater levels in #Ottawa have finally declined significantly but lower does not mean gone as PCR test positivity rates are still at 7.6% ( ). 🧵1/ covid.gilchrist.ca/Ottawa.html
RSV WW levels are 7.7x lower than the peak which was much lower than last year. Influenza had much higher peaks this year than last year and while Flu A levels are low, Flu B hit its peak at the beginning of March and is now declining but still above the peak from last year. 2/
Ottawa Public Health (OPH) stopped updating its COVID dashboard and now produces new stats on their updated respiratory virus dashboard ( ). 3/ottawapublichealth.ca/en/reports-res…
#Variant update for #Ontario, #Canada (to Mar. 14, 2024)
The BA.2.86.* #Pirola clan of variants has made most other lineages extinct in Ontario. The SanKey shows the situation is now much simpler and almost exclusively JN.1 and descendants. Graph tools by @Mike_Honey_ 🧵1/
Right now the JN.1 and JN.1.4 Pirola variant are still the most prevalent. The JN.1.11.1 variant, its descendants (KP.*) and other FLiRT variants will be the ones to watch as they start growing in Ontario and may be able to escape immunity from JN.1 infections. 2/
The % positivity from viral tests is quite a mixture now, the original Coronavirus in lead at 8.2% with COVID-19 in 2nd (6.3%) then Entero/Rhinovirus (5%), Human metapneumovirus (4.6%), Influenza A (4%), Influenza B (3.8%), Parainfluenza (3.4%) ( ). 3/ publichealthontario.ca/en/Data-and-An…