Inverted & Perverted Reflexes

The first description of the paradoxical (inverted) triceps reflex

French neurologist Alexandre-Achille Souques (1860–1944)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

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Definition

“elicitation of the movement opposite to that normally seen when the reflex is elicited”

2/
Mechanism

“a lesions simultaneously affecting the roots and spinal cord”

Damaged root
- interrupt local reflex
- absence of contraction

Damaged spinal cord
- interrupt corticospinal tract
- hyperactive response of the lower spinal segment

3/
Why is there a hyperactive response?

4/ Image
Inverted radial (supinator) reflex

Level of pathology: C5/6
Positive response: Flexion of fingers and extension of elbow rather than elbow flexion when eliciting the supinator (brachioradialis) jerk.

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Inverted radial (supinator) reflex

doi.org/10.1212/WNL.00… via: Neurology

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Inverted radial (supinator) reflex

via: Dr Mahyuddin Mohamed

7/
Inverted radial (supinator) reflex

via: Oren Goltzer

8/
Paradoxical (inverted) triceps reflex

Level of pathology: C7/8
Positive response: Flexion of elbow rather than extension when eliciting the triceps jerk.

via: MedAruth

9/
Paradoxical (inverted) triceps reflex

doi.org/10.1212/WNL.00… via: Neurology

10/
Inverted biceps reflex

Level of pathology: C5/6
Positive response: Extension of elbow rather than flexion when eliciting the biceps jerk.

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Inverted knee jerk

Level of pathology: L2/3/4
Positive response: Flexion of knee (hamstring contraction) rather than knee extension when eliciting the knee or quadriceps jerk.

12/
Special

Absent quadriceps reflex with distant toe flexor response
Level of pathology: L3/4

doi.org/10.1016/j.clin… via: Clinical Neurology and Neurosurgery

13/
Clinical clues

C5 lesion – inverted biceps
C6 lesion – inverted radial
C7 lesion – inverted triceps

14/ Image
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More from @theneurolander

Dec 14
Myotonic disorders!

“after a fright, or in an unexpected joyous movement, this convulsive constriction occurs in all limbs…the victim can not stand upright”

Prussian physician Asmus Julius Thomas Thomsen (1815–1896)

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/ Image
Definition

“difficulty in relaxation of a muscle after maximum voluntary contraction”

It can be specifically
- aggravated by conditions
- affecting regions of the body
- triggered

2/ Image
Myotonic or Tennessee fainting goat

“important in history due to role of chloride channel in muscle excitation”

- 1880s, Marshall County
- CLCN1 gene

via: jimmywan87

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Read 28 tweets
Dec 10
Dermatome!!!

“Dermatomal man, early twentieth century”

University of Edinburgh Image Collections

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

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History

“dermatomal charts are primarily derived from 3 sources”

Head & Campbell
-herpetic eruptions

Foerster
-rhizotomy in chronic pain
-dermatomal overlap

Keegan & Garrett
-various diseases
-exam & surgical correlate: 53%

American neurosurgeon John Jay Keegan(1889-1978)
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Definition

“area of skin in which sensory nerve derive from a single spinal nerve root”

- 31 spine segments
8C + 12T + 5L + 5S + 1 coccygeal
- dermatomes exist for each spinal nerve, except C1

3/
Read 25 tweets
Dec 9
Hereditary Ataxias!!!
Spinocerebellar ataxias (SCA)

“SCA1 …. the unstable CAG trinucleotide repeat expansion”

American geneticist Harry T. Orr

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/
SCA definition

“complex group of heterogeneous degenerative diseases of the cerebellum and its connections”

2/
Worldwide distribution of SCA subtypes

21% SCA3, Brazil & Portugal
15% SCA2, India & Singapore
15% SCA6, Japan & Germany
6% SCA1, South Africa
5% SCA7, South Africa
3% SCA8, worldwide

<1% rare
SCA 10, SCA 12, SCA 14, SCA17

3/
Read 18 tweets
Dec 8
Dancing larynx!!!

“a variant of palatal tremor?”

British neurologist Anette-Eleonore Schrag
1999, first description
@UCLIoN

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/ Image
Definition

“rhythmic vertical laryngeal cage movements of varying frequency with synchronous movements of the tongue, posterior pharynx, and the palatopharyngeal arch”

- not affecting uvula

2/ Image
Pathophysiology

Variant of palatal tremor
- oscillatory firing of neurons in the inferior olives

Functional

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Read 7 tweets
Dec 8
Rabbit syndrome!!!

“a peculiar extrapyramidal reaction”

Canadian psychiatrist André Villeneuve
1972, the first report

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/
Definition

“stereotyped vertical, rhythmic movements, similar to the chewing movements of a rabbit”

5 Hz
Lips produce a popping sound
Not tardive dyskinesia!
- persist stage I sleep

2/
Pathophysiology

- cholinergic system?

3/
Read 15 tweets
Dec 5
Belly Dancer's Dyskinesia!!!

“first described by Antonie van Leeuwenhoek in 1723 when he himself experienced the symptoms”

#MedTwitter #neurotwitter #EndNeurophobia #tweetorials

1/
Definition

“rhythmic, involuntary contractions of the diaphragm resulting in undulating, rhythmic movements of the abdomen resembling a belly dance”

-bilateral, most freq
-limited to axial musculature
-sometimes painful
-no suppress on breath holding
-150 contraction/min

2/
History

1723, Leeuwenhoek
- 1st report
- diaphragmatic flutter

1976, Nichols
- 1st report
- abdominal wall dyskinesia
- phrenic palsy in a newborn

1990, Iliceto
≠ diaphragmatic flutter

3/
Read 26 tweets

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