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Toni Choueiri, MD Profile picture
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Dec 29 • 11 tweets • 21 min read
It is this time of the year again: TOP 10 GU Oncology clinical papers/trials in 2022:

Some negative, some positive, but we learned from all!

Feel free to add more & retweet & tag anyone involved

This is not an exhaustive list!

@OncoAlert @DanaFarber

#OnwardFor2023 Image
1/ #ARASENS phase 3 trial shows ⬆️OS with darolutamide in combination with docetaxel and ADT in #mHSPC (vs docetaxel + ADT alone) with similar AE profile, leading to @US_FDA approval.
#MatthewSmith @BertrandTOMBAL @MGHMedicine @NEJM
nejm.org/doi/full/10.10… ImageImageImage
2/ In #PCa patients with detectable PSA after prostatectomy, lymph node RT + ADT+ PBRT⬆️freedom from progression compared to ADT+ PBRT and PBRT alone according to #SPPORT trial.
@_APollack @DrHowardSandler @TheLancet
thelancet.com/journals/lance… ImageImage
3/ Another @US_FDA approved triplet therapy in de novo #mCSPC: abiraterone (+ ADT + docetaxel) improves OS and radiographic PFS compared to SOC±RT in the #PEACE-1 trial with modest⬆️toxicity (mainly HTN).
#Fizazi @AlbertoBossial @GustaveRoussy @TheLancet
thelancet.com/journals/lance… ImageImage
4/ In 2 #STAMPEDE RCTs: Abiraterone (±enzalutamide) combined with ADT in high risk M0 #PCa⬆️metastasis-free survival, OS, PFS, DSS. Unclear benefit of adding enzalutamide with⬆️toxicity.
@AttardLab @Prof_Nick_James @mattsydes @TheLancet @Silke_Gillessen
thelancet.com/journals/lance… ImageImageImage
5/ IL-15 superagonist NAI can induce persistent CR in 71% of BCG-unresponsive #NMIBC with #CIS + 89% avoided cystectomy and 100% DSS at 2 years.
@UroCancerMD @UclaUrology @DrPatSoonShiong @NEJMEvidence
evidence.nejm.org/doi/full/10.10… ImageImageImage
6/ In the GETUG-AFU V05 #VESPER trial, neoadjuvant dd-MVAC for M0 #MIBC ⬆️3-year PFS compared to Gem/Cis.
@GETUG_Unicancer @JCO_ASCO
ascopubs.org/doi/full/10.12… ImageImageImage
7/ Promising data from 1L enfortumab vedotin + pembrolizumab in cis-ineligible, metastatic #urothelial cancer (EV-103): ORR 73.3%, CRR 15.6% with good tolerability. Median DOR &OS exceeding 2 years. 👀on phase 3 trial.

@DrChrisHoimes @DrRosenbergMSK @JCO_ASCO @OncologyTimes ImageImage
8/ Data from the #IMmotion010 trial: adjuvant atezolizumab unfortunately did not meet its primary endpoint of improved DFS in #RCC at high risk of recurrence after nephrectomy.
@montypal @UzzoRob #AxelBex @AlbigesL @brian_rini @crisuarez08
thelancet.com/journals/lance… ImageImageImage
9/ Promising efficacy of cabozantinib/nivolumab in the treatment of papillary, unclassified and translocation-associated #RCC with a 47.5% ORR (median PFS 12.5 mos and OS 28 mos). Limited response in chromophobe RCC.

@ChungHanLee3 @motzermd @JCO_ASCO
ascopubs.org/doi/full/10.12… ImageImage
10/ In the phase 2 #SAKK 01/10 trial, single-dose carboplatin followed by involved-node RT in stage II #seminoma showed a favorable efficacy and toxicity profile with 93.7% PFS at 3 years.
@Alex_Papachris @SAKK_ch @TheLancetOncol ImageImageImage

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More from @DrChoueiri

Toni Choueiri, MD Profile picture
May 27
Now that #ASCO22 abstracts are released, more insights into Top 10 #GUOnc abstracts (still many LBAs):

@DanaFarber_GU @OncoAlert @ASCO @ASCOPost

1/LBA| Chris Ryan @OHSUKnight=>The long awaited EVEREST study with adjuvant everolimus in RCC: stay tuned!
2/Interesting relationship between DepOR and clinical outcomes in CM-9ER! Greater proportions of pts receiving Nivo+Cabo had deeper responses vs SUN. This translated into better PFS/OS

Dr. Cristina Súarez @vallhebron Image
3/Better HEQOL baseline scores were associated with significantly reduced death on Checkmate-214. Pts with improved/stable 6mo-HRQoL had a 52% reduction in risk of death compared to pts who had worsened.
@CellaDavid @MSSatNU Image
Read 10 tweets
Toni Choueiri, MD Profile picture
Dec 28, 2021
It is this time of the year again: TOP 20 GU Oncology clinical trials published in 2021:

Some negative, some positive, some led to @FDAOncology approval; we learned from all!

Feel free to add & retweet & tag anyone involved

This is not an exhaustive list

@OncoAlert
1/ (177Lu)–PSMA-617 showing improved PFS and OS in pre-treated mCRPC patients vs. SOC, in addition to a favorable safety profile @sartor_oliver @morr316 @NEJM
nejm.org/doi/full/10.10…
2/ MRI with targeted & standard biopsy in men with MRI suggestive of prostate cancer (PC) was noninferior to standard biopsy for detecting clinically significant PC &resulted in less detection of clinically insignificant cancer @NEJM @TobiasNordstrom
nejm.org/doi/full/10.10…
Read 22 tweets
Toni Choueiri, MD Profile picture
Aug 18, 2021
1/ On the heels of @ASCO #ASCO21 plenary, we are happy to share the results of KEYNOTE-564 trial of adjuvant pembrolizumab in mRCC just published in @NEJM ! A step towards better outcomes for all our patients with kidney cancer!
nejm.org/doi/full/10.10…
@OncoAlert @tompowles1
2/ Following nephrectomy for kidney cancer, a significant percentage of patients will experience disease recurrence, most of them with distant metastases, highlighting the need for effective adjuvant therapies.
3/ Despite many decades of research and clinical investigations, there are currently no globally approved adjuvant regimens for the management of #kidneycancer
Read 16 tweets
Toni Choueiri, MD Profile picture
Apr 22, 2021
Just out @NatureMedicine: Inhibition of HIF-2 alpha in RCC with belzutfian (MK-6482) - phase 1 trial and biomarker analysis- 1st study to report on the 2nd gen. HIF-2 inhibitors in pts with metastatic ccRCC!! @OncoAlert

A THREAD!

nature.com/articles/s4159…
1/The HIF2 axis biology is fascinating culminating in a 2019 @nobel prize, including our own @DanaFarber @kaelin_lab
2/In this study: 95 patients were enrolled (dose-escalation cohort: n=43 and dose-expansion cohort: n=52). Among these, 55 had advanced ccRCC, with a median age of 62 years, a median of 3 previous systemic therapies, and 76% (n=42) with intermediate/poor @IMDConline risk groups.
Read 16 tweets
Toni Choueiri, MD Profile picture
Jun 22, 2020
Proud of this @NatureMedicine collaboration with #FeedmanLab on a novel method detecting early stage RCC in plasma&urine w/cell-free DNA methylomes. Work led by super stars @PierVitaleNuzzo @Jberchuck @keegankorthauer #SandorSpisak
1/ RCC kills 175,000 patients worldwide with no screening test available acsjournals.onlinelibrary.wiley.com/doi/full/10.33….
A screening test that detects RCC while still localized (2/3 RCCs) will possibly reduce mortality. RCC and CNS tumors do not shed much cfDNA in the blood!
2/ Developed initially by @decarvalho_lab (co-senior author), we validated this ultra-sensitive cfMeDIP-seq using plasma cfDNA and, for the 1st time, cfDNA from urine samples collected in our #GelbCenter (Chair M. Pomerantz)
Read 13 tweets
Toni Choueiri, MD Profile picture
May 29, 2020
1/ Our latest work was just published in @NatureMedicine!
Congratulations to first author Super-Star @BraunMDPhD and to all authors. #CathyWu #SachetShukla @LabSignoretti @VanAllenLab #FreemanLab #SharpeLab
@DanaFarberNews @DanaFarber
#kcsm #KidneyCancer
doi.org/10.1038/s41591…
2/ Our study analyzes patient samples from 3 prospective clinical trials of PD-1 blockade.
The study includes 592 tumors that were profiled by WES, RNA-seq, and/or IF for CD8+ T cells on samples collected before treatment with Nivolumab (anti-PD1) or Everolimus (mTOR inhibitor)
3/ We evaluated genomic correlates of response to PD-1 inhibitors in ccRCC.
Molecular features that had been previously suggested to correlate with outcomes (e.g. TMB, NeoAg load) were not found to be predictive of benefit from PD-1 blockade.
Read 19 tweets

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