I just heard about the Damar Hamlin collapse during MNF. I understand a defibrillator was needed and used with CPR on the field.

Blunt chest trauma during early (30mSecond) part of ventricular repolarization (T-wave upstroke) can illicit an "R-on-T" equivelant and cause V-Fib.
This is what we call 'Commotio Cordis' which refers to the sudden arrhythmic death caused by a blunt specifically-timed chest wall impact. Commotio Cordis is seen mostly in athletes in their teens and early 20's

I don't have all the facts, but I just found out and need more info
If this is true, then it was not a head or neck injury which is what most people automatically assume!

Tell me what you know so I may give a more informative assessment....
I was able to find a video on twitter and I can say that Commotio Cordis is the event that led to Damar Hamlin's Ventricular Fibrillation cardiac arrest.

Let's pray for him!

When we defibrillate and immediately resuscitate a ventricullar Fibrillation cardiac arrest patient
As in a witnessed or in-hospital V-Fib cardiac arrest, if Return Of Spontaneous Circulaton (ROSC) is achieved promptly, then prognosis is markedly improved and the following 2 hours define the likelihood of "walking out of the hospital"
The resultant "Cardiac Arrest" is very much different than a "Heart Attack"

The former, in the setting of Commotio Cordis" is otherwise healthy patient, has increased proportionally to the rapidity of normal cardiac activity

Defibrillation is vital for recovery ofcardiac rhythm
When we see a post defibrillation survivor of Ventricular Fibrillation Cardiac Arrest victim, the patient is taken to the ICU or CCU for stabilization and a comprehensive evaluation which follows.

A wide range of hemodynamic and medications supportive resources are ready
I am optimistic and hope to hear positive medical updates about #DAMARHAMLIN
What I do not know is the amount of time #DAMARHAMLIN from the time of impact (cardiac arrhytmia onset) to the time of defibrillation.

When was CPR initiated.
How long was his brain deprived of Oxygen and circulation?

These factor affect prognostic indicators of recovery.

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More from @MdFacep

Aug 4, 2022
The rates of arterial and venous thrombotic complications in COVID-19 are low in non-hospitalised individuals with asymptomatic or mild disease.

Thrombotic risk increases with severity of COVID-19 illness, with those on intensive care being at greatest risk.
@ACEPNow @EricTopol
Thrombotic disease includes PE, DVT, arterial emboli, CVA, OMI, end-organ infarcts, and generalized microthrombi.

The two common end results of severe & citical #COVID19 disease leading to ICU stays, vents, and death are Cytokine Release Syndrome (CRS, inflammation) & thrombosis
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2. VTE (Venous Thrombotic Embolism) is more common in critically ill, on vents, and in those with past h/o VTE

3. D-dimer less useful

4. So do we ID those at risk?
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Jul 27, 2022
I get asked why do I post that cases and hopsitalizations will be so drastically reduced by late September?

Our immunity with three key elements:

1. Vaccine induced circulating immunity (cnAbs-blood)
2. Mucosal alveolar imm. (lungs)/PI
3. Cellular imm.

Based on our mucosal alveolar immunity from prior infection, and the circulating immunity gained from vaccination, supported by our humoral immunity, and having an estimated 60-70% of the US previously infected, I hope for a reduction of 50-75% in hospitalization before late Sept
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Jul 26, 2022
Let's discuss boosters. 🧵

How many are there?
What are they?
When do we expect them?
Which one would do the most good in the big picture?

That means the one that reduces infection, transmission, and reduce hospitalization so you may make an informed decision.

1/12
How maqy are there?
Moderna will have 3 options. Pfizer 2-TBA
1. The current 1273 S-protein targeting vaccine(first gen. monvalent vaccine against the ancestral VOC)

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What are they and when can we expect them?
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3/12
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Jul 25, 2022
Here I go again:
ER visits for #CovidIsNotOver are declining.

That is usually followed by a decline in hospitalization.

I know it is unpopular to talk of declining numbers, but that is what I am seeing.

We should see a 50-75%+ decline in hospitalization over the next 8 weeks.
COVID is not mild.

ER visits are going down and hospitalization may peak between 45K-55K-I posted this before

It was similarly unpopular in January when I said hospitalization will go down in February '22 down by 80%

Others were calling for end of time
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It has proven to be more accurate than other indicators, particularly for severe disease, hospitalization, and critical disease (vents, respiratory failure/arrest)
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CV-19 enters other ACE2 expressing cells
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BA.5 key observations. We need data!
🧵

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It enters and replicates efficiently is cells devoid of TMPRSS2

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