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Dr Claire Taylor Profile picture
@drclairetaylor
Jan 4, 2023 • 9 tweets • 3 min read • Read on X
🧵 1/
This may be the most important graph of the pandemic so far. We already know what the ou...
2/ We know that 3 infections compared to one can result in an increase in health problems.
8 x risk of being hospitalised
5x risk of cardiovascular disease
4 x risk of blood clots

nature.com/articles/s4159…
3/ Obviously individual risk will depend on your risk to start with.
However, if that’s what it looks like after 3 infections, what will it look like after 10?
4/ what’s the end game here?
#XBB15 is even more infectious. And possibly more evasive to vaccines and prior immunity.
A more infectious, evasive variant means more infections.
More infections= see graph above.
More infections=more new variants.
Playing with 🔥
And a reminder- Covid is a vascular disease (of the blood vessels), not a respiratory disease.
We can’t even get anti-viral treatment for all these infections, unless highly vulnerable.
All should have access to treatment given the sequelae above.
Lastly. Children. How many infections will they get in childhood?
We have no lasting immunity.
They are going to keep being re-infected.
May as well add in the viral persistence research (as if reinfection data and vascular inflammation wasn’t bad enough)
Are we even clearing infections between infections?
What if you have 2 variants persisting at once?
This is why I can’t sleep 😴
The paper this is from is nature.com/articles/s4159… lead researcher @zalaly The adapted graph is by @Wikisteff and the data is from figure 5 of the paper. Thanks to all. Image

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More from @drclairetaylor

Dr Claire Taylor Profile picture
Feb 15
Long covid clinics are full of previously healthy people. 🧐
Where are all the
-rheumatology patients on DMARD or biological medication?
-diabetics?
-cardiac patients?

Are their medications protective for long Covid?
A study in Scotland looked at some medications at time of Covid infection and found injectable anti-coagulants to be the only one that was protective.
But many meds they could not analyse for various reasons
We urgently need to look at them all. Image
Some rheumatologists have already postulated that their medications may be protective-
Dr Laster said in 2022 said he was not seeing much long Covid in his patients on immunosuppressive therapy
This mirrors what I have observed
Image
Image
Read 17 tweets
Dr Claire Taylor Profile picture
Feb 12
Long Covid is a disease that can be measured

Study
🔴113 long Covid patients,39 healthy controls
📢Result
long Covid patients had complement activation (component is first line of immune system), and increased vascular markers.
Long Covid is an inflammatory&vascular disease🩸
They used proteomics to analyse blood.

🔴LC patients exhibited increased complement activation during acute disease, which persisted at 6-month follow-up.

The complement system is part of the innate immune system&contributes to immunity by targeting pathogens&damaged cells
🟢 blood complement levels normalized in Long Covid patients recovering before their 6-month follow-up
Read 12 tweets
Dr Claire Taylor Profile picture
Feb 10
Do we actually have an end game for a virus that rots bloods vessels and trashes brain cells? 🧠
It will still kill us, just much more slowly
⏰ ⏰ ⏰
We still have time to change the trajectory- but I suspect there is a point at which one cannot undo all those infections..🦠
We could be storing up:
Dementia
Parkinson’s disease
MS
Cardiac failure
Strokes
Heart attacks
Metabolic issues
Diabetes
Fatty liver
Raised cholesterol
Effects on eyesight
Autoimmune diseases
Damaged immune systems that can’t fight normal infections

And more…
That’s in addition to all the problems from long Covid already affecting people.

Spreading a disease with no cure that we can’t become immune to makes absolutely no sense whatsoever.
We aren’t even trying.
Like not even a tiny teeny weeny bit.
Shameful.
Read 4 tweets
Dr Claire Taylor Profile picture
Feb 2
Throwing children with ME/CFS into water to ‘make’ them swim since they were adamant it was psychological. They did not swim. They nearly downed.
This is the murky history of #MECFS
And still there are those who insist ME/CFS is psychological.
HOW is this medicine?
We may have stopped throwing children into swimming pools but not much else has changed. Those with #LongCovid are now going through the same thing with being told it is psychological and to exercise their way out of it.
How long will this continue?
I treat the medical problems I see.
I see autonomic dysfunction, a hyper immune response, viral reactivation and endothelial dysfunction. Amongst other pathologies.
How long until others see it? 👀
Some already do but not many.
@doctorasadkhan @Sunny_Rae1
Read 10 tweets
Dr Claire Taylor Profile picture
Jan 21
‘Anyone that was going to have long Covid has it by now’.
Nope. There is not a ‘type’ of person who gets #LongCovid that is wishful thinking.
There may be some susceptibilities but anyone can get long Covid.
I saw people throughout 2023 who had got
It after multiple infections Image
The @StatCan_eng study showed long Covid increased by infection.
By infection 3, 38% had long Covid symptoms
That does not look like a graph showing the susceptible got it on
Infection 1 and everyone else was A-ok. 🤷🏻‍♀️ Image
Add to that the data from @zalaly reinfection study which clearly shows cumulative burden of disease with REINFECTION Image
Read 14 tweets
Dr Claire Taylor Profile picture
Jan 16
There has been many amazing #LongCovid studies recently I’ve just been mulling them over.
🏆 long covid patients get muscle NECROSIS with exercise.
N-protein in the muscles but ALSO controls.

We are going to find viral persistence everywhere, aren’t we?
No one wants to say it SARS-CO-V-2 representation. On the right is the nucleocapsid protein this is just N protein surrounded by RNA. On left whole virus with N protein in middle and membrane protein and spike protein on outside
‘Exercise-induced amyloid-containing deposit accumulation in skeletal muscle’

What???
Why on earth are we telling these people to exercise?
So they can destroy their muscle tissue and deposit more amyloid and feel terrible?
There is a baseline of amyloid in pre pandemic samples but higher in LC patients and higher after exercise

‘The underlying reason…remains Elusive’
Amyloid was Expected to be found in capillaries. Repeating may work this out. ? Issues with lab technique.
Read 18 tweets

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