Thread by @DrJackKruse

A. CLOCK and BMAL1 are positive regulators of circadian gene expression, and PER and CRY are the NEGATIVE FEEDBACK LOOP regulators that operate under day and night cycles. These are the positive and negative feedback arms of the circadian mechanism.

B. Both loop must be coupled properly to terrestrial light to operate well and control all growth and metabolism, protein synthesis and hormone production and release. This increases the periodicity of the SCN. It also controls receptor biology. It controls EVERYTHING.

C. If they are not properly coupled to the light and dark cycles the eventual results are the extinction of both sides of the feedback loop. So when sunlight is absent we lose control of the negative feedback loop of the circadian mechanism controlled by PER2 in the SCN

D. This is what causes the NAD+ drop in mtDNA. Few know that TCA enzyme flux is controlled by the circadian mechanism. That is how all human disease begins.

E. It is circadian biology that couples all the molecular clock genes in humans and the SCN of the eye drives the program and the major timekeeper.

F. The SCN is the metronome of biology & it looses accuracy via periodicity as PER2 drops. PER2 is critical in controlling optical periodicity of the mechanism.

G. Poor sunlight, darkness, geoengineering will have a major effect on cellular hypoxia via lowered sunlight. Cell hypoxia is controlled by hypoxia inducible factor (HIF-1).
Do you know the link of HIF 1 to the sun?

H. Here is the kicker: HIF-1 belongs to the same protein family as the light-inducible circadian core protein Period 2 (PER2) Here is your link. (Liu et al., 2012).

I. When you're a mitochondriac you must begin to investigate whether hypoxia- and HIF1A-PER2-dependent pathways might regulate SIRT expression to show why light trumps food in the controlling flux of the TCA cycle. Some of figured it out below. Leptin Rx born

J. When you do this due diligence you find out HMEC-1 transcriptional or translational analyses with a PER2 or HIF1AKD revealed PER2-HIF1A-dependent regulation of SIRT3 does occur in all mammals under hypoxic conditions. Masks are a real bad idea for fatties.

K. Then you should remember when mammals took over the world. They exploded after the last global hypoxic event - KT event. It interupted photosynthesis and it decreased oxygen production as a result.

L. Dinosaurs died out when photosynthesis was disrupted because sunlight went dark and things got real cold for an extended period of time. HIF-1 was explosive for mammals birds and deadly for non therapod dinosaurs.

M. Modern humans rarely expose their skin to sunlight and this is one reason cardiac death is a leading cause of death in humans.

IS THERE NOW EVIDENCE THAT INTENSE RED LIGHT can do THE same thing using the PER circadian gene system? YEP

N. Does this imply that red light is a drug equivalent?

YEP

Is there more to this circadian story you need to know? YEP

O. Adenosine-mediated increase of cyclic AMP is a core component of PER2 expression and PER2-mediated ischemic preconditioning of the heart. This means sunlight creates a perfect circadian situation for oxygen in the heart and its conduction system!

P. The most dramatic event in the history of Earth was the arrival of sunlight and its effect on oxygen on Earth due to photosynthesis. Sunlight caused the great oxygen event. This is why oxygen, sunlight, and PER2 are coupled.

Q. With sunlight, trillions of photosynthetic algae could now make oxygen, transforming the entire planet's atmosphere setting up the perfect storm for the evolution of a mammalian mitochondrial world post KT until human technology changed the signal.

R. Blue light and nnEMF liberate Vitamin A from our cells and cell membranes to raise its presence in the blood plasma and this lowers plasma levels of Vitamin C and Vitamin D.

S. When Vitamin A is liberated by non terrestrial light or trauma, it becomes an aldehyde that destroys the small molecule modulators of the mammalian circadian mechanism. PER1 and PER2 are gears in that eye clock mechanism periodicity drops and quantum timing lost in mtDNA =

T. Lost periodicity of PER1 and PER2 = more mtDNA mutations. Human mitochondrial DNA mutates 15-20 times as fast as nuclear DNA. In primates, that mutation rate is only 5-10 times greater in mtDNA than nDNA.
nnEMF = faster epigenetics = disease creation

U. mtDNA mutations always cause cellular disorganization. Cellular organization comes from information processing in the cell. Today we know information is synonymous with energy in physics. Centralized biology remains ignorant of this connection.

V. Energy is trapped directly at the electronic level in cells. Energy is stored as vibrational & electronic bond energies in biochemicals (PER/HIF-1), but also in the structure of the system: its membranes, and in gradients, fields and flow patterns, compartments, organelles &

W. cell water and tissues really have organization behind their QED magic.

X. Cellular disorganization always manifests in diseases before death; illness comes before death in most living sequences unless we are talking acute trauma. This points out why the information of the organization is as important as energy flux in a cell to maintain wellness.

Y. The energy cost is tremendous for a defective mitochondrial DNA and this amplifies mutations in this genome when protein signals are calling for higher turnover. The nuclear genome is designed by nature to be quite stable and quiescient.

Z. When your environment is energized by abnormal parts of the electromagnetic spectrum it increases ubiquitin marking in proteins to signal for higher protein turnover. This robs you of energy = low redox state

Z1. Mitochondrial DNA is more vulnerable to alteration than nuclear DNA, mainly for two reasons. First, mitochondria are a major source of intracellular reactive oxygen species (ROS). Therefore mitochondrial DNA is under much stronger oxidative stress than is nuclear DNA.

Z2. Second, mitochondria have a matrix-side negative membrane potential for oxidative phosphorylation. This membrane potential concentrates lipophilic cations inside mitochondria up to approximately 1,000-fold. This is how light controls metabolism. Light>Food

Z3. The charge density change is massive. It mimics what vasopressin does to water with all its excess negative charges.

Z4. This increase of light energy within our environment increases epigenetic expression in the entire genome, while seriously causing a massive cost of energy to be used in the process. This increases the error rates in mtDNA further = raising heteroplasmy

Z5. heteroplasmy to develop much faster than the normal rate in aging. That rate is usually at 10% per decade. This is a big freaking deal, folks. Without energy, life first gets sick, then it dies earlier than it should.

Z6. Looks like I was right about Alzheimer's now too. Circadian clock protein Bmal1 regulates the dynamics of beta-amyloid creation. You do not need a DNA change to get this result.

Z7. Most scientists think that to have order you need chemical bonds, and you do not — you just need interactions or a lack of interactions that affect entropy in feedback control loops. This is what sunlight provides circadian controllers.

Z8. Researchers have already shown that you don’t need chemical bonds or gene mutation to get chaos. Confined objects can self-organize. It follows if you allow them to lose their confinement they lose the ability to self-organize which leads to misfolded proteins.

Z9. From Musiek lab: jem.rupress.org/content/early/…