Immune dysfunction after Covid19.
We've known since 2020.
We do not know if it is progressive, but w reinfections pretty high & viral persistence occurring it does not matter.
A thread from my threads - the top 12 papers showing clear immune dysregulation in chronological order!
Great article. @DavidJoffe64 quote, "please do not psychologise ME/CFS or Long Covid...this is a direct organic, neurological condition, with a plethora of complex outcomes, including severe consequences for autonomy and quality of life." 1/6 bps.org.uk/psychologist/w…
2 and, "The presence of depression, dementia, and PSTD are clearly evident from the vast body of literature." and so many more! Read it!
3 Then Janina Bradshaw, "Another issue I think is important to reflect on as psychotherapists is this: why are so many people so willing to accept the continuing immense impact the Covid is having on the population?"
2/n "Concerningly, though, “living with it” means tolerating greater suffering and instability than we used to do, often without fully noticing or talking about it."
3/n "In the short term, living in a state of peak denial helps us cope. In the long run, it will be our undoing."
An NAS professor of Speech and Hearing Sci leads an imaging study on youth during early pandemic, submits to the NAS journal, reviewed by a Prof of Biostatistics and Prof of Psychology, no one an expert in the topic, calls it causation by lockdowns as happened at near same time?
It gets worse, one reviewer Leah Sommerville has a real conflict as she has collaboration with Prof Kuhl's husband, Andrew N. Meltzoff. Take a look
@RetractionWatch take a look. This should be coming. osf.io/4mxfa/
Long Covid Delphi study preprint just out. 179 panelists. Statements were combined into specific areas: definition, diagnosis, treatment, research, and society. Aims to give recommendations to physcians and researchers. papers.ssrn.com/sol3/papers.cf…
Note: needs some correction (I asked) as left off a full name and to add the SI w names of panel members.
Methods: A 3-round modified Delphi consensus methodology was distributed internationally to 179 healthcare professionals, researchers, and persons with lived experience of Long COVID located in 28 countries across the world.
1/4 Now that I have had time to read through this, it is a solid study of attenuated immune response (CD8+ T cells) after infection focussing on mRNA vaccine-induced immunity & adding to the now large body of evidence that as authors state, (see tweet 2) cell.com/action/showPdf…
2/4 "This suggests that SARS-CoV-2 virus infection may cause long-term damage to the patients’ immune system well after viral clearance."
3/4 There are some limitations, but this study adds, among other things, to the body of evidence showing that most immunologists, at least those studying Covid, in fact argue immune dysregulation - at least for some time.
Body of evidence here. whn.global/scientific/cov…
Has been some discussion on two plots about hazard ratios from reinfections.
This one is from tabulated data in the Aly paper put into a plot. It is NOT 'made up' any more than any real plot of scientific data.
This one was a hypothetical plot not based on specific scientific data. It is NOT real.
This latter plot and the data are described in some detail here.