Thread by @chydorina

I am fascinated w/ the potential for sodium bicarbonate in #MECFS + #Fibromyalgia.
Used by athletes + studied for decades + there is OK evidence of weak performance gains
BUT
@remissionbiome is interested in myalgia, muscle soreness, DOMS.
1/n

pubmed.ncbi.nlm.nih.gov/29344729/

Four things have really captured my attention. A new topical delivery version that makes the GI effects a non-issue. 2. Vagal nerve connections. 3. DOMS (delayed-onset muscle soreness) is reduced. 4. direct lactate effects are seen (very common in #MECFS). 2/n

Characterization of the Human Skeletal Muscle Metabolome for Elucidating the Mechanisms of Bicarbonate Ingestion on Strenuous Interval Exercise
pubs.acs.org/doi/pdf/10.102… 3/n

4/n

This tie-in to hypoxic conditions is especially interesting.
pubmed.ncbi.nlm.nih.gov/29344729/
5/n

I am surprised how well this stuff seems to help muscle pain. Its a bit odd actually. It really really helps and its super fast. I am more than a bit miffed as while there is decent literature on bicarb on muscle soreness - that the topical version works well its surprising. 6/n

The company scientist wrote this: so grain of salt
multisportdistribution.co.uk/blogs/news/the… 7/n

@PeterAttiaMD tweeted re: PR lotion + was on fence for performance BUT its muscle soreness that I am interested in here.
If lactic acid/lactate is one of the main culprits of myalgia and the topical lotion affects it - maybe this makes a lot of sense? 8/n

https://twitter.com/PeterAttiaMD/status/1508077279171293186

There is some evidence that the oral bicarbonate does affect DOMS (delayed onset muscle soreness) for athletes. I have often wondered if the myalgia soreness of #MECFS and #Fibromyalgia is biochemically similar to DOMS in athletes. 9/n

Because lactate is an important marker for us in @remissionbiome this is really key for us. We will be using lactate meters throughout the experiment and there is a possibility that lactate consuming bacteria triggered the 'event'. 10/n

We will be trying out PR lotion (I have been experimenting for a week) + using oral bicarbonate for the vagal trigger benefit.

"Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges" 11/n

doi.org/10.1016/j.phrs…

peterattiamd.com/does-pr-lotion…

@remissionbiome "Perhaps a cheap and freely available antacid will rival VNS in treating a wide variety of inflammatory disorders?"
ncbi.nlm.nih.gov/pmc/articles/P…