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🕸️Dr.T, PhD Profile picture
@chydorina
Feb 2, 2023 • 13 tweets • 6 min read • Read on X
I am fascinated w/ the potential for sodium bicarbonate in #MECFS + #Fibromyalgia.
Used by athletes + studied for decades + there is OK evidence of weak performance gains
BUT
@remissionbiome is interested in myalgia, muscle soreness, DOMS.
1/n
pubmed.ncbi.nlm.nih.gov/29344729/ Image
Four things have really captured my attention. A new topical delivery version that makes the GI effects a non-issue. 2. Vagal nerve connections. 3. DOMS (delayed-onset muscle soreness) is reduced. 4. direct lactate effects are seen (very common in #MECFS). 2/n
Characterization of the Human Skeletal Muscle Metabolome for Elucidating the Mechanisms of Bicarbonate Ingestion on Strenuous Interval Exercise
pubs.acs.org/doi/pdf/10.102… 3/n
4/n Image
This tie-in to hypoxic conditions is especially interesting.
pubmed.ncbi.nlm.nih.gov/29344729/
5/n
I am surprised how well this stuff seems to help muscle pain. Its a bit odd actually. It really really helps and its super fast. I am more than a bit miffed as while there is decent literature on bicarb on muscle soreness - that the topical version works well its surprising. 6/n
The company scientist wrote this: so grain of salt
multisportdistribution.co.uk/blogs/news/the… 7/n
@PeterAttiaMD tweeted re: PR lotion + was on fence for performance BUT its muscle soreness that I am interested in here.
If lactic acid/lactate is one of the main culprits of myalgia and the topical lotion affects it - maybe this makes a lot of sense? 8/n
There is some evidence that the oral bicarbonate does affect DOMS (delayed onset muscle soreness) for athletes. I have often wondered if the myalgia soreness of #MECFS and #Fibromyalgia is biochemically similar to DOMS in athletes. 9/n
Because lactate is an important marker for us in @remissionbiome this is really key for us. We will be using lactate meters throughout the experiment and there is a possibility that lactate consuming bacteria triggered the 'event'. 10/n
We will be trying out PR lotion (I have been experimenting for a week) + using oral bicarbonate for the vagal trigger benefit.

"Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges" 11/n

doi.org/10.1016/j.phrs…
peterattiamd.com/does-pr-lotion…
@remissionbiome "Perhaps a cheap and freely available antacid will rival VNS in treating a wide variety of inflammatory disorders?"
ncbi.nlm.nih.gov/pmc/articles/P…

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More from @chydorina

🕸️Dr.T, PhD Profile picture
Dec 6
Toxoplasmosis infection is one of my opportunistic co-infections and the threat of it getting into the central nervous system (brain) is ever present (it can be a high risk in those that have immunosuppression as well as during pregnancy).

Its not a parasite that can really be successfully treated w/ current pharma drugs - they are not effective on all stages and can be much too hard on altered sick bodies dangerous as the mess with folate metabolism.

I use a Herbal protocol designed by master herbalist Dr. Stephen Buhner (search Buhner toxoplasmosis and you will find it) and I do a 21 day course 2-3 times a year. With addition of a few other herbs its also a good EVB herbal protocol.

I am always looking for alternate ways of keeping the toxo latent and making sure cysts dont grow. Probiotic mixtures that increase SCFAs - seem a useful add-on for anyone dealing with toxoplasmosis.

Probiotic-induced changes in intestinal microbiome inhibits Toxoplasma gondii infection
parahostdis.org/journal/view.p…Image
Image
Multi-strain mixture composed of: Image
stephenharrodbuhner.com/wp-content/upl…
Read 4 tweets
🕸️Dr.T, PhD Profile picture
Dec 1
We need an X prize for a biomarker(s) for #LongCovid.

Currently there are no well accepted clinical endpoints that can be used in clinical trials and this more than anything else is hampering research progress and drug development.

There has got to be a couple billionaires out there who would fund an X prize (or we just tap $1 from every person who has #LongCovid and run a few hundred X prizes). With 200+ million people globally, the demand/resource is there. Plus, it would be a billion dollar company eventually.

Special bonus prize of course for the marker also applying to #MECFS.

Home test/commercial test would be the goal.
All we really have right now are 'survey's' - questionnaires were people are asked questions like 'what is your level of fatigue'. This is not acceptable.
Research-only markers are not going to cut-it. Home testing is the goal (and if along the way we find a few that require more expensive tech, well it wont be a waste of time).
Read 9 tweets
🕸️Dr.T, PhD Profile picture
Nov 29
"The patients taking the synbiotic reported a significantly superior drop in post-exercise malaise (68.0% on average) at 3-month follow-up as compared to the placebo group (37.5%)."

Small trial finds significant effect of probiotic mixture on PEM with increase of choline in the thalamus, creatine in white/grey front matter, and N-acetyl aspartate before/after

Synbiotic (probiotics+) trial worth mentioning. The trial may have been small (n=32) but the significance of the intervention on PEM was quite high. Interestingly there was no effect on 'fatigue' per se - it was actually Post-exertional malaise where the benefit was found.

What did they do? 3 months of a combo probiotic supplement that included:
- Lacticaseibacillus rhamnosus DSM 32550, -
- Humiome® Lactiplantibacillus plantarum DSM 34532 (formerly known as L. plantarum TIFN101),
- Bifidobacterium lactis DSM 32269,
- Bifidobacterium longum DSM 32946,
- FOS fructooligosaccharides (2.5 mg) - a 'pre-biotic'
- Zinc (5 g).

The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE)

link.springer.com/article/10.100…Image
Image
Image
Read 5 tweets
🕸️Dr.T, PhD Profile picture
Nov 18
You are competing RIGHT NOW for ENERGY with all the parasites and pathogens that are living on and in you. Yes, there are pathogens that can hijack the products of our mitochondria and co-opt ATP production for replication. In the process they will create more inflammatory reactive oxygen species, more systemic inflammation, and more dysfunction.

ENERGY production is a resource, and not one we have enough of a surplus of to share with pathogens - treat whole body pathogen load!
Treat what can be treated.
you eat, candida eats
Read 11 tweets
🕸️Dr.T, PhD Profile picture
Oct 3
It is possible to have normal oxygen saturation and pathological hypoxia at the same time? In certain conditions like #ME and #LongCovid this is likely what is actually occurring. Some tissues (like brain and muscles) are not getting enough oxygen.

To make matters worse it is possible that epigenetic 'memory' of the sick state is part of what might keep us sick (even when an acute illness ends) - and that changes in oxygen gradients in tissues (pathological hypoxia) is a trigger for these epigenetic changes.

We don't have a definitive answer yet but interactions between inflammation + the immune system + pathological hypoxia (low oxygen) may provide some clues that this is indeed occurring.

It can be hard to wrap ones head around having low oxygen or hypoxia when your smart watch shows normal oxygen saturation.

BUT! It is oxygen USE that is the issue, not that it is there is the first place. When we look at oxygen getting to the brain and oxygen use in the muscles, we see a different story.

It is obvious that hypoxia would interact with the immune response and inflammation and changes oxygen gradients in different tissues.

"These changing oxygen gradients are exaggerated during inflammation, where oxygenation is often depleted owing to alterations in tissue perfusion and increased cellular activity."

Pathological hypoxia also interacts with Mast Cells - causing them to degranulate and release inflammatory meditators. Obviously those that have MCAS might need to pay particular attention to hypoxia as a risk factor to help manage Mast Cells.

If activity also restricts oxygen in brain and muscles this could be one reason why physical activity can lead not just to crashes but also MCAS flares and its maintenance when all other triggers have been removed. (note: mast cells can also release interferon-gamma!!).

Hypoxia potentially interacts with ME and LC disease processes in many ways, affecting inflammation, immune responses including mast cells, and even epigenetics. Hypoxia might induce epigenetic changes in immune cells, such as chromatin remodeling, which can have long-lasting effects leading to 'immune memory' and a change of state from pre-illness that is hard to turn back.

Practically, this means that immune cells exposed to hypoxia may retain a "memory" of this exposure, affecting their response to future infections or inflammatory signals.

"How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia"Image
link in comments: nature.com/articles/s4157…
potential interventions: compression pants and compression + external counterpulsation (EECP)
verywellhealth.com/enhanced-exter…
Read 6 tweets
🕸️Dr.T, PhD Profile picture
Sep 26
Screens and Neuroinflammation

We all know that too much screen time can be hard on the eyes and brain, but if you have #ME or #LC it can be a major element of daily life that needs to be managed.

This is because screens both indirectly and directly are related to neuroinflammation - which we already suffer from.

I wish this paper focused less on healthy people/kids and developmental patterns and more on disease conditions and biology - but regardless - I copied the relevant sections on neuroinflammation and circadian cycle disruption (article is paywalled).

This is a topic that really needs to be covered for #ME specifically given our underlying neuro-issues. Using larger screens, blue light blockers, e-ink readers, special eye safe screens, screens with low flicker frequency and checking your tech to make sure if is not one of those units that people complain about are all options. I also wear 'Avulux' migraine glasses.

I upgraded to a 15.6" laptop with a high resolution screen a year ago and this was a great move for me. The smaller the screen is the harder I 'look'.

Search my feed for previous discussions of screen usage: "screens (from:chydorina)"

Interconnections of screen time with neuroinflammation (2024)Image
article link:
link.springer.com/article/10.100…
Image
Read 12 tweets

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