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🕸️Dr.T, PhD Profile picture
@chydorina
Feb 2, 2023 • 13 tweets • 6 min read • Read on X
I am fascinated w/ the potential for sodium bicarbonate in #MECFS + #Fibromyalgia.
Used by athletes + studied for decades + there is OK evidence of weak performance gains
BUT
@remissionbiome is interested in myalgia, muscle soreness, DOMS.
1/n
pubmed.ncbi.nlm.nih.gov/29344729/ Image
Four things have really captured my attention. A new topical delivery version that makes the GI effects a non-issue. 2. Vagal nerve connections. 3. DOMS (delayed-onset muscle soreness) is reduced. 4. direct lactate effects are seen (very common in #MECFS). 2/n
Characterization of the Human Skeletal Muscle Metabolome for Elucidating the Mechanisms of Bicarbonate Ingestion on Strenuous Interval Exercise
pubs.acs.org/doi/pdf/10.102… 3/n
4/n Image
This tie-in to hypoxic conditions is especially interesting.
pubmed.ncbi.nlm.nih.gov/29344729/
5/n
I am surprised how well this stuff seems to help muscle pain. Its a bit odd actually. It really really helps and its super fast. I am more than a bit miffed as while there is decent literature on bicarb on muscle soreness - that the topical version works well its surprising. 6/n
The company scientist wrote this: so grain of salt
multisportdistribution.co.uk/blogs/news/the… 7/n
@PeterAttiaMD tweeted re: PR lotion + was on fence for performance BUT its muscle soreness that I am interested in here.
If lactic acid/lactate is one of the main culprits of myalgia and the topical lotion affects it - maybe this makes a lot of sense? 8/n
There is some evidence that the oral bicarbonate does affect DOMS (delayed onset muscle soreness) for athletes. I have often wondered if the myalgia soreness of #MECFS and #Fibromyalgia is biochemically similar to DOMS in athletes. 9/n
Because lactate is an important marker for us in @remissionbiome this is really key for us. We will be using lactate meters throughout the experiment and there is a possibility that lactate consuming bacteria triggered the 'event'. 10/n
We will be trying out PR lotion (I have been experimenting for a week) + using oral bicarbonate for the vagal trigger benefit.

"Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges" 11/n

doi.org/10.1016/j.phrs…
peterattiamd.com/does-pr-lotion…
@remissionbiome "Perhaps a cheap and freely available antacid will rival VNS in treating a wide variety of inflammatory disorders?"
ncbi.nlm.nih.gov/pmc/articles/P…

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More from @chydorina

🕸️Dr.T, PhD Profile picture
Jun 29
Treatments that have helped patients go into remission or improve #MECFS #LongCovid - thanks to HIP!

If you have any experience with any of these interventions please comment and add your experience. This could become a REALLY valuable thread.

Full thread copied to X in images.
1/xforums.phoenixrising.me/threads/list-o…Image
2/x Image
3/x Image
Read 22 tweets
🕸️Dr.T, PhD Profile picture
Jun 23
Leaky gut and Berberine?

This figure is amazing. Let me explain. Its so obvious when you know what you are looking at.
ZO=Zonulin, Occludin, and Claudin are proteins that are involved in barrier function in the gut. Here they are stained with immunofluorescence. The regular spacing represents intact barrier function.

First line: The control is for 'healthy epithelium'.
Second line: When they add berberine to controls it gets a bit more disorganized.
Third line: When they add pro-inflammatory cytokines IFN-g and tnf-a the barrier function becomes totally disorganized.
Fourth line: When they add berberine to the pro-inflammatory condition it normalizes somewhat.

Berberine is notorious for being not an easy supplement to use, not very bioavailable and can cause side-effects.
Liposomal forms may help to counteract these issues:Image
Image
researchgate.net/publication/23…
Read 4 tweets
🕸️Dr.T, PhD Profile picture
Jun 18
When you look at MECFS management protocols (even ones that have been around for ages like Dr. Sarah Myhill's) one of the first set of recommendations is to address nutrient deficiency and mineral deficiency and heavy metals.

WHY?

Because nutrients and minerals are the co-factors that make our biochemical pathways work properly. Heavy metals are blocks to proper biochemical function. You simply cannot properly treat chronic illness without first repleting minerals and providing the body with the building blocks it needs for biochemical function.

I finally got my first set of Oligoscan results this week. I have been doing parts of the Born Free protocol (@joshual_tm) for a few months now but have been unable to get the CMA or mineral testing so was not able to personalize what I was doing. As of 2 weeks ago I am now doing ~95% of it and am committing to it for at least the next few months. I have also been detoxing mold and heavy metals and was interested to see if my detox pathways were blocked.

I am including the full Oligoscan results below. As 'non-optimal' as they are - I was actually quite pleased with the results and I think they suggest the work I have done the last few months has not been in vain (I was expecting them to be a LOT worse).

I am pretty stoked now to optimize my mineral intake based on actual data and also to be able to do monthly testing. A recent OAT and @biomesight is on the way and a CMA is also in the works.

The one big problem area was LOW ZINC and lowish COPPER. Zinc is probably THE most important mineral across the board for most issues and it is likely driving a lot of the blocks and pathway dysfunctions. Low copper is also an issue and will need to be repleted together. I will be tweaking my nutrient supplements (more D, C, Bs, E, A) and also adding Chromium, Zinc, Mitosynergy transdermal Copper, and more Silica and Molybdenum than I was using before.Image
The mineral deficiency score is driven in part by the low zinc which affects a LOT of the body's biochemical function. Image
Heavy metals falling into line. Aluminum, Cadmium, Tin highest but will continue chelation protocol. Image
Read 5 tweets
🕸️Dr.T, PhD Profile picture
May 17
What does the scientific literature say about the risk of neuropsychiatric side-effects and Montelukast?

I am incredibly angry after a google scholar search. The consensus (even with the black box warning) is that it is a SAFE drug and common side effects are related to allergy (see pic below).

BUT!!!!

The X-poll suggests that of ~1/3 of respondents that took the drug had "awful side effects" and from reading the responses we can clearly see these were not your run of the mill mild adverse side effects.

Suicidality and psychosis as a big deal.

So, what is it about the #MECFS #LongCovid population that raises the risk of neuropsychiatric side-effects so sharply?

Because like with most safety issues to do with Pharma - adverse events have been buried as deeply as possible so unravelling this is nearly impossible as no one has done adequate studies.

Even more insidious, one of the studies I read suggested that allergic rhinitis itself drove neuropsychiatric effects - thus placing the blame on the allergy response itself.

Hmm...

So, despite the black box warning - the literature mostly suggests the pattern is NULL - invalid, weak, non-existent.

Once again patients experience gets thrown out the window.

My take on this is that pre-existing neuroinflammation likely increases RISK. This could be due to pathogens and it could also be due to mast cell dysfunction itself. There is obviously something going on here - something probably covered up and thus unravelling this from public data hard to impossible.

At least we can warn each other about risks. I am not giving medical advice about whether to take or not, however safer options for MCAS at least DO EXIST. In my mind Montelukast is not a first line medication for MCAS due to this issue.Image
Ugh...even worse.
link.springer.com/article/10.100…
Image
Ugh...and even more terrible.
doi.org/10.1016/j.psym…
Image
Read 4 tweets
🕸️Dr.T, PhD Profile picture
Apr 13
Minimally invasive vagus nerve stimulation modulates mast cell degranulation via the microbiota-gut-brain axis to ameliorate blood-brain barrier and intestinal barrier damage following ischemic stroke

sciencedirect.com/science/articl…
Image
Image
Image
Read 4 tweets
🕸️Dr.T, PhD Profile picture
Apr 9
Where do you start? Are you reacting to everything?

Three steps are essential when starting treatment for #MECFS #LongCovid.

1. Deal with mast cell reactivity
2. Deal with GI issues

Wait, you ask, didnt you say three?

Well yes. The last, which applies to both mast cell (MCAS) and GI issues is DIET changes.

Diet for most of us is what IS driving the new food sensitivities. The only option is to cut them out. These are not allergies, these are autoimmune/mast cell reactions - you cannot keep eating this stuff and expect to recover.

Start by removing dairy, gluten, corn, soy and following the AIP Autoimmune Paleo diet or the PK diet. Add fiber.

For 1. mast cell issues - it takes a multi-layered approach. Try combinations of H1/H2 antihistamines such as certrizine/famotidine, nasalcrom, fibroprotek (supplement by algonot), luteolin, quercetin, ketotifen (and DIET)

For 2. GI issues - it takes a multi-layered approach but a combination of BPC-157, zinc-carnosine, L-glutamine, butyrate, d-lactate free probiotic mix, are a good place to start (and DIET).

Once a bit of stability has been achieved work on minerals, nutrients, neuroinflammation and the gut-brain axis will begin to normalize.

You are re-building health. The foundation needs to be built before the house.
Image
Autoimmune Paleo Guide: thepaleomom.com/wp-content/upl…
Read 5 tweets

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