1/2 Example 1:
🚬 Imagine if the average person from the moment they're born were taught to be 2 pack a day smoker.
⛔️ Now imagine a fraction were born into families that were 0 pack a day smokers.
Would we expect that latter group to have greater longevity than the former?
🚬 Imagine if the average person from the moment they're born were taught to be 2 pack a day smoker.
⛔️ Now imagine a fraction were born into families that were 0 pack a day smokers.
Would we expect that latter group to have greater longevity than the former?
2/2 Example 2:
Now imagine most people averaged 100 #LDL cholesterol over their lifetime.
But a fraction were born with a genetic mutation that kept their average at 20.
Would we expect that latter group to have greater longevity?
Now imagine most people averaged 100 #LDL cholesterol over their lifetime.
But a fraction were born with a genetic mutation that kept their average at 20.
Would we expect that latter group to have greater longevity?
If genetically low LDL/ApoB had universally a net benefit -- this would be strong evidence that indeed this particle is pathogenic -- which is to say, disease-causing overall (not just atherogenic)
But does existing genetic data support this hypothesis? Is there clear longevity?
But does existing genetic data support this hypothesis? Is there clear longevity?
Hence my interest whenever it comes up (ie @theproof's podcast re centenarians)
Genetically low LDL associating w/ longevity benefit against the avg population would meet with the expectation of LDL/ApoB being truly pathogenic (no CVD to non-CVD tradeoff)
Genetically low LDL associating w/ longevity benefit against the avg population would meet with the expectation of LDL/ApoB being truly pathogenic (no CVD to non-CVD tradeoff)
https://twitter.com/realDaveFeldman/status/1619133525617446913?s=20&t=Hl1rZP9KR9zBKX-W2kcfeQ
When I get back more bandwidth soon, I'm hoping to get in more time to set up study on these kinds of questions.
For example, do we find those born with PCSK9 loss of function (LOF) have an average lifespan that exceeds the general population?
For example, do we find those born with PCSK9 loss of function (LOF) have an average lifespan that exceeds the general population?
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