First and foremost, both gentlemen were very cordial and professional. No ridicule, name-calling, or any other emotive personal attacks, etc..
2/ Which -- as you all know -- I'm a strong advocate for.
@NutritionMadeS3 represented the pro-LDL/ApoB lowering position well. (Note I've linked/tweeted his videos several times)
@ifixhearts brought forward the importance of metabolic health, and fault in it getting ignored...
May 23 • 4 tweets • 2 min read
Yes, @ProfTimNoakes — The study actually gets quite detailed in that area. Note they include LDL-C >= 190 strata across the range of metrics. In fact, they are far and away the largest sample of this with CCTA/CAC of any study I know of.
2/4 And,"While these data on our patient are comprehensive and provide potential new insights, they are limited in scope and timespan. It’s certainly possible this patient is an outlier, or that their progression of plaque will take place later, or many other such possibilities."
2/4 ... "This proportion was similar to that in patients with lower LDL-C levels. Third, CCTA-ascertained absence of CAC indicated no detectable plaque in 86.8% of patients, including those with LDL-C levels greater than 190 mg/dL."
Apr 13 • 5 tweets • 3 min read
1/ A lot of times polls like these are more interesting for the talk they generate than even the results themselves.
Here are a few featured comments and my added thoughts...
2/ A lot of people wanted greater specificity on what I meant by "rich" -- I left this more to the reader's interpretation. IMO, I'd have thought this would be in a highest quantile, such as top 1/3rd or 4th of typical aggregate diet.
It will help provide data that helps confirm/disconfirm the long standing assumption that "healthy user bias" has been effectively adjusted for by researchers... 2/ If you're not familiar with "healthy user bias" (HUB), it's a known potential confounder where those who are doing what they feel is healthy in one regard (such as avoidance of red meat), can often have other likewise "healthy habits", such as more exercise, less smoking, etc
2/ For a relevant example-- this study makes direct comparisons on symptomatic ("chest pain") patients ultimately diagnosed AMI (acute myocardial infarction, aka heart attack) vs symptomatic yet diagnosed as not having had an AMI... journals.sagepub.com/doi/full/10.41…
1/ Reminder: I realize it’s the single hardest concept to get across, but for all these years I have and continue to suggest there’s a crucial case of lipoprotein profiles as often more a reflection of disease than the independent drivers of it. (ie — from 2018 re general👇)
2/ For example, I certainly know so much more on the workings of #LEM* than when I tweeted this from 2018, but does the foundation still hold up… do I think this is more relevant or less? Definitely more!
(*Obligatory mention of @nicknorwitz here and others re coming paper!)
2/ They've kindly agreed to provide a coupon code "CITIZEN" for their package to help get both a discount and allow opting in your anonymized data to our OYL anonymous data pool. (Just like we do at our site)
No, there's no $$$ or compensation for us or anything like that...
Feb 1 • 6 tweets • 3 min read
I'm incredibly honored at @nicknorwitz's offer for a transplant -- so blessed to have such a good friend they'd donate their own...
- eyebrows! 😂
Okay, but seriously, let's talk about disappearing eyebrows and how it can potentially signal reasons of concern...
But first I want to get a few polls* on what those following my account feel themselves 👇
(*yes, I know there’s a margin for trolling, as always. 😂)
2/4 When I’ve said I’m “cautiously optimistic” regarding context of metabolic fat-adaptation, you take that as…
1) I’m very confident LDL is of no concern.
2) I don’t know if LDL is of concern in this context, it very well could be. But I current lean toward the optimistic.
Jan 19 • 10 tweets • 3 min read
1/ One of the toughest skills to master is avoiding sarcasm save those moments where you're pretty sure it will be well received by almost everyone.
Occasionally, I do a self check to see how that's going. Gotta say, I'm pretty pleased with some of the most recent ones...
2/ Everyone can related to the "I'm doing Diet X..." challenge. This one from May...