Mike Glover Profile picture
Feb 15 17 tweets 142 min read
@TumorBoardTues @TomJayram @arnabguonc @UroCancerMD @vinay_onc @simon_p_kim @AlexAlvaro_PSC @AlyaShamsan @MichaelStaehler @DrOmarMian @kaydaustin @josiegarcia1 @LeeJonesMBA @mcricardoa @UroDocAsh @Uromigos @AJangMD @BenMironMD @ChrisSweens1 @Tanjin097 @NikiTripathi27 1/15 #TumorBoardTuesday #BladderCancer #OncTwitter

71 y/o 👨🏽‍🦳
Former 🚬
👨‍🏭Worked in various factories in 80s-00s
Recently diagnosed metastatic #UrothelialCancer (lymph nodes/lung)

🤨 What would you pick for your first line of therapy?
@TumorBoardTues @TomJayram @arnabguonc @UroCancerMD @vinay_onc @simon_p_kim @AlexAlvaro_PSC @AlyaShamsan @MichaelStaehler @DrOmarMian @kaydaustin @josiegarcia1 @LeeJonesMBA @mcricardoa @UroDocAsh @Uromigos @AJangMD @BenMironMD @ChrisSweens1 @Tanjin097 @NikiTripathi27 @PGrivasMDPhD @PauloBergerot @spsutkaMD @shilpaonc @montypal @tompowles1 @NazliDizman @DrKarineTawagi @ShuchiGulati @wandering_gu @KidneyCancerDoc 4/15 #TumorBoardTuesday #BladderCancer

👨🏽‍🦳Patient started on gemcitabine and cisplatin
🧷🪡 some mild paresthesias after C3

After 4 cycles
🩻 CT scan 📷 shows
👎🏽 Growth of multiple lymph nodes
👎🏽 pulmonary 🫁 nodules, previously 2 cm now 3cm
🙁
@TumorBoardTues @TomJayram @arnabguonc @UroCancerMD @vinay_onc @simon_p_kim @AlexAlvaro_PSC @AlyaShamsan @MichaelStaehler @DrOmarMian @kaydaustin @josiegarcia1 @LeeJonesMBA @mcricardoa @UroDocAsh @Uromigos @AJangMD @BenMironMD @ChrisSweens1 @Tanjin097 @NikiTripathi27 @PGrivasMDPhD @PauloBergerot @spsutkaMD @shilpaonc @montypal @tompowles1 @NazliDizman @DrKarineTawagi @ShuchiGulati @wandering_gu @KidneyCancerDoc 5/15 #TumorBoardTuesday
👨🏽‍🏫Mini tweetorial 1
🧐How do we think about platinum resistance?

🤨How many cycles did they get?
4 cycles seems adequate
📚ncbi.nlm.nih.gov/pmc/articles/P…
🤔How quickly did they progress?
platinum refractory = best response is PD
🧐How does it affect outcomes?
@TumorBoardTues @TomJayram @arnabguonc @UroCancerMD @vinay_onc @simon_p_kim @AlexAlvaro_PSC @AlyaShamsan @MichaelStaehler @DrOmarMian @kaydaustin @josiegarcia1 @LeeJonesMBA @mcricardoa @UroDocAsh @Uromigos @AJangMD @BenMironMD @ChrisSweens1 @Tanjin097 @NikiTripathi27 @PGrivasMDPhD @PauloBergerot @spsutkaMD @shilpaonc @montypal @tompowles1 @NazliDizman @DrKarineTawagi @ShuchiGulati @wandering_gu @KidneyCancerDoc @rafee_talukder @arkhaki 👨🏽‍🏫Mini tweetorial 3 👨🏻‍🏫

219 Pts divided into cohorts based on time from 1L chemo to ICI
🔸< 3m
🔸3-6m
🔸> 6m

🕵🏽Then analyzed response to ICI between cohorts
🔹PFS: < 3 m shorter than > 6m (3m vs 5m, p < 0.05)
🔸OS: < 3m shorter than > 6m (4m vs 14m p < 0.05)

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