Thread by @NiacinGlutamine

#COVID19 #CVD #MetabolicDisorder and #FlushNiacin (will need equimolar Glutamine w/ it) per Double-Blinded Randomized Placebo-Controlled Clinical Trials Evidence in Humans:

“This meta-analysis involved 2,110 patients with T2DM from 8 RCTs across a wide range of patients’… twitter.com/i/web/status/1…

^ High triglyceride to HDL-cholesterol ratio as a biochemical marker of severe outcomes in COVID-19 patients
clinicalnutritionespen.com/article/S2405-…

Low HDL and high triglycerides predict COVID-19 severity
nature.com/articles/s4159…

Triglyceride/High-Density Lipoprotein Cholesterol Ratio is… twitter.com/i/web/status/1…

^ "In our study, high niacin intake during lifestyle intervention was associated with a larger reduction of liver fat content without affecting insulin sensitivity"

“Among 58 subjects with nonalcoholic fatty liver disease (NAFLD) at baseline, NAFLD resolved in 23 subjects during… twitter.com/i/web/status/1…

^ “Participants in an open label study at Kaiser Permanente in San Francisco received an average of 3000mg a day. After a mean duration of one year, 81% of patients had experienced reductions in intra-abdominal fat as measured by a single slice abdominal CT scan (the method… twitter.com/i/web/status/1…

^ Shall we post the myriad of empirical evidence of flush niacin's prowess in normalizing microvascular, vascular inflammation, clotting, thrombotic, & coagulation parameters as demonstrated in countless double-blinded randomized placebo-controlled clinical trials in humans too?

^ Before that, check out the below summary of findings (with the actual data) from my own double-blinded randomized placebo-controlled trial of flush niacin (at ~1 g dose) as monotherapy treatment against the progression of the symptomatology of early-detected acute #COVID19 in a… twitter.com/i/web/status/1…

^ More on #Glutamine's Essential Role with #FlushNiacin, intersecting on #COVID19:

“Therefore, NAD+ boosters would be effective for the prevention of COVID-19 or immediately after the infection with SARS-CoV-2"

"the glutamine supply for both the de novo cdc.gov/ncbddd/sicklec…… twitter.com/i/web/status/1…

^ Forgot these below other papers, including more unequivocal evidence of flush niacin (w/ equimolar glutamine to optimally fuel) as causative #COVID19 treatment from even more double-blinded randomized placebo-controlled clinical trials in humans:

"NAD+ journals.asm.org/doi/abs/10.112…… twitter.com/i/web/status/1…

... #Parkinsons !

"results support a possible mechanism of microglial innate immune activation by SARS-CoV-2, which could explain the increased vulnerability to developing neurological symptoms akin to Parkinson’s disease in COVID-19 infected individuals, and a potential… twitter.com/i/web/status/1…

/ / /

I N T E R M I S S I O N

(there is sooo much more; and I forgot some other key double-blinded randomized placebo-controlled trials in humans aside from clotting, which I will add later too)

In the meantime, please enjoy the below:

Recorded Call to NIH reporting niacin… twitter.com/i/web/status/1…

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https://twitter.com/niacinglutamine/status/1626276874530746369

^ As promised, what follows below is a summary/list of the findings from all (at least to my knowledge) double-blinded randomized placebo-controlled clinical trials in humans which all consistently evidence Flush Niacin's unsurpassed beneficial effects against ALL negative… twitter.com/i/web/status/1…

...
"Preincubation of blood with niacin at 0.3, 1.0 and 3.0 mM resulted in significant inhibition of maximal adenosine diphosphate (ADP)- (p=0.03), and collagen-induced platelet aggregation (p=0.01), and reduced activity by VerifyNow (p=0.007) bedside analyser. Surface platelet… twitter.com/i/web/status/1…

... The increased plasma PAI-1 activity and PAI-1 mRNA in liver induced by dexamethasone (0.8 mg IP) were attenuated by 3 weeks of pretreatment with niacin.

Niacin, by decreasing PAI-1 expression, may potentiate fibrinolysis, thereby decreasing the stimulation of atherogenesis… twitter.com/i/web/status/1…

^ There are even more double-blinded randomized placebo-controlled clinical trials in humans coming, but I hope you noted this key excerpt from above:

“Niacin, by decreasing PAI-1 expression, potentiates fibrinolysis, thereby decreasing the stimulation of ahajournals.org/doi/10.1161/01…… twitter.com/i/web/status/1…