SARS-CoV-2 : Non structural protein NSP, structural proteins and ORF, in LAYMAN terms 😀
(3rd part)
In the previous threads, we had tried to describe as simply as possibe the 29 proteins of the virus including 4 structural proteins (spike, membrane, envelope and nucleocapsid)
2) ... 16 non-structural NSPs including, 11 encoded in ORF1a, and 5 in ORF1b, and finally 9 accessory proteins from ORF3 to ORF10.
These proteins have different functions and their mutations will therefore affect the functioning and the spread of the virus.
3) All of these functions have been described in a remarkable study, in not very layman terms.
Sorry for that 😒
72 billion land animals (9 times the nb of people on earth) are killed for food globally.
In US, every year are killed :
9,300,000,000 chickens
3,800,000,000 fishes
214,000,000 turkeys
124,000,000 pigs
33,000,000 cows
23,000,000 ducks
2) ANIMAL CRUELTY
"To reduce the costs of housing thousands of animals, farmers put pigs in cages that are barely larger than their own bodies. They keep six or more hens in wire cages, each with an area similar to an iPad where they cannot spread their wings in their lives."
Following the warm messages after my first thread, I will continue on this topic. Previously, to facilitate understanding, I would like to come back to the LIFE CYCLE of the virus, using images from a wonderful video.
1. TRANSMISSIBILITY
The virus is airborne transmitted when people breathe in air contaminated, and target different types of healthy respiratory cells.
2) INFECTIVITY. The first stage of the infection happens when the virus comes into contact with the host cell. The spike protein is responsible for making this contact and starting the infection.
SARS-CoV-2 : Non structural protein NSP, structural proteins and ORF, in LAYMAN terms 😀
Maybe some of you have been confused between technical terms (like me sometimes 😂) to understand SARS-CoV-2. I have therefore tried as simply and briefly as possible to explain these terms
2) ... hoping that the experts, will not hold it against me for these extreme simplifications.
The simplest image to try to describe this virus is perhaps that of boxes that we are going to open gradually.
3) The first "box" contain open reading frames (ORFs), first divided into two parts, ORF1a and ORF1b, located in the first two-thirds of the viral genome.
16 proteins are non-structural proteins or NSP: the first 11 are encoded in ORF1a whereas the last 5 are encoded in ORF1b.