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Mar 6 • 5 tweets • 4 min read
Official from the U.S. CDC (27 Feb 2023)
"Emerging evidence suggests that SARS-CoV-2, the virus that causes COVID-19, can have lasting effects on nearly every organ and organ system of the body weeks, months, and potentially years after infection"
#NotMild
cdc.gov/nchs/data/nvss…
#PreventSARSCOV2Reinfection
Public Health Ontario's Evidence & Risk Assessment for SARS-COV-2
(June 23 2022) stated:
"Preventing high levels of COVID-19 community transmission may mitigate the
incidence of PACS (long COVID) and its long term impacts"
publichealthontario.ca/-/media/Docume…
Official from Public Health Ontario SARS-COV-2 Risk Assessment (June 2022)
"Emerging evidence indicates that reinfection adds risk of all-cause mortality, hospitalization and
adverse health outcomes during acute & post-acute SARS-CoV-2 reinfection."
#DontGetReinfectedBySARSCOV2
Public Health Ontario SARS-COV-2 Risk Assessment
"Additionally, the risk and burden may increase in a graded manner according to the number of infections, which suggests preventing reinfection could reduce overall SARS-CoV-2 burden of death & disease"
#DontGetReinfectedbySARSCOV2
Official from Public Health Ontario SARS-COV-2 Risk Assessment (June 2022):
"Current COVID-19 vaccines and previous SARS-CoV-2 infection do not provide sterilizing immunity (i.e., full protection from infection or reinfection)."
#DontGetReinfectedbySARSCOV2

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More from @0bj3ctivity

Tom Andrews Profile picture
Mar 7
I just finished watching World War Z, a 2013 film based on a 2006 book. It was interesting to reflect on the similarities and differences between that pandemic of a hypothetical novel (in this case 'zombie') virus, and a real novel pandemic virus we did end up facing, SARS-COV-2.
SARS-COV-2 spreads fast, but at a more realistic speed that is sufficient to spread around the world in days, weeks and months, rather than seconds, minutes, and hours as the film.

Like most pathogens it only kills a relatively small proportion of those people it infects, but it
has some powerful weapons: it's high transmissibility and it's ability to cause immune dysregulation and dysfunction, and evade or damage aspects of the immune response. Both have been refined the more host bodies we allow to be infected and reinfected, to leave us facing
Read 13 tweets
Tom Andrews Profile picture
Jan 22
German Federal Health Minister warns: "multiple coronavirus infections can seriously affect the immune system...affected are coping with an immune deficiency that can no longer be cured. Research has shown very clearly that many people are"
21 January 2023
earlybulletins.news/politics/22709…
"Basically, the gig is up.

Lauterbach has broken the silence on a major catastrophe. This is the first time a major public health official has acknowledged the severe damage Covid does to the immune system, not to mention Long Covid."

jessicawildfire.substack.com/p/the-gig-is-u…
"Over the next several months, we can expect a slow, grudging admission that western leaders have done catastrophic damage to society by allowing and encouraging Covid to spread freely. They don’t have a choice at this point..."
Read 7 tweets
Tom Andrews Profile picture
Jan 17
"Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells"

June 2011
ncbi.nlm.nih.gov/pmc/articles/P…

1/x
"Understanding the mechanisms of augmented bacterial pathogenicity in post-viral infections is the first step in the development of an effective therapy. This study assessed the effect of human coronavirus NL63 (HCoV-NL63) on the adherence of bacterial pathogens associated...
2/x
... with respiratory tract illnesses. It was shown that HCoV-NL63 infection resulted in an increased adherence of Streptococcus pneumoniae to virus-infected cell lines and fully differentiated primary human airway epithelium cultures. The enhanced binding of bacteria ...

3/x
Read 53 tweets
Tom Andrews Profile picture
Jan 15
"A method of separating extracellular vesicles from blood shows potential clinical translation, and reveals extracellular vesicle cargo gremlin-1 as a diagnostic biomarker"

January 2022
sciencedirect.com/science/articl…

1/x
"Highlights

Extracellular Vesicles/EVs can be tested in small clinically relevant serum samples.

Antibody-coated immunobeads is a simple, fast, user-friendly method for this."

2/x
"EVs may help diagnose breast cancer patients versus those with a benign mass.

Gremlin-1 cargo of EVs may be a diagnostic biomarker for breast cancer."

3/x
Read 6 tweets
Tom Andrews Profile picture
Jan 15
"We discovered that influenza and COVID-19 destroy a previously unknown natural immunity that we need to resist invasive fungal infections," says Nicole Sarden, a PhD candidate at the University of Calgary and first author on the study.

news-medical.net/amp/news/20230…

1/x
"Fungi such as Aspergillus are so common in our surroundings that we breathe in hundreds to thousands of spores every day.

In healthy people, fungi typically pose no threat, but they can cause deadly infections in those with compromised immune systems...

2/x
"However, it is increasingly recognized that viral infections such as influenza or SARS-CoV-2 can increase the risk of invasive Aspergillus infections even in healthy people."

3/x
Read 22 tweets
Tom Andrews Profile picture
Jan 14
"LRRC15 inhibits SARS-CoV-2 cellular entry in trans"

October 2022

pubmed.ncbi.nlm.nih.gov/36228039/

1/x
"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is mediated by the entry receptor angiotensin-converting enzyme 2 (ACE2). Although attachment factors and coreceptors facilitating entry are extensively studied, cellular entry factors inhibiting viral...
2/x
... entry are largely unknown. Using a surfaceome CRISPR activation screen, we identified human LRRC15 as an inhibitory attachment factor for SARS-CoV-2 entry. LRRC15 directly binds to the receptor-binding domain (RBD) of spike protein with a moderate affinity and inhibits...
3/x
Read 37 tweets

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