SARS-COV-2 and cancer: So, what's the evidence, can SARS-COV-2 itself cause cancer, & separately can it increase risk & rapidity of death from existing cancers, & reactivate dormant cancers?

Let's start with what causes cancer 🧵

https://x.com/arijitchakrav/status/1799685306414993755?t=Esomhpq83rd9odDVOD0mSA&s=03

How do viruses cause cancer? 🧵

https://x.com/arijitchakrav/status/1799962890457559497?t=_JeDnEmHjN-4AutQgWwTjg&s=03

How are y'all liking living with COVID?

How's it working out for you? (the survivors so far anyway)

How many of you liking living with long COVID, immune dysfunction, increased risk of other infections & the organ damage?

The accelerated dementia, increased cancer risks?

https://twitter.com/0bj3ctivity/status/1850900230788550864

You realise this isn't going away right?

The new variants are going to keep arising because we keep allowing ourselves (as a population at least, we know the smart ones are avoiding it) to be regularly infected

So if you keep getting reinfected, how do you see your future?

@RageSheen I think to an extent this is a somewhat privileged take, for those removed from the day to day struggle for existence, for those who need little and want little from society, or community, & who have the agency to cut themselves off from it (to a greater degree). @RageSheen I also think it's a somewhat narcissistic & introvert take, arguably putting introversion on a pedestal, expressing schadenfreude at the harms befalling those who are more extrovert

I thought it useful to share this response from ChatGPT to the query:

"What proportion of people infected with SARS-COV-2 may remain anti-N negative & why?"

Hopefully people find it a useful counterargument to the suggestion that some may "avoid infection altogether"
1/x
🧵 The proportion of people infected with SARS-CoV-2 who may remain anti-N (antibody to nucleocapsid protein) negative can vary based on several factors, including the timing of the antibody test relative to infection, the individual’s immune response, & the specific test used

2/x

@jim_reed @northernsi @PJeffcock @BBCNews Jim, please don't take the criticism personally

We really appreciate it's even being reported

It would be great if you could write something on how healthcare worker safety was being undermined by incorrect IPC guidance

Many doctors & nurses died because of this @jim_reed @northernsi @PJeffcock @BBCNews It didn't just harm doctors & nurses, it harmed care workers, ambulance workers, patients, relatives, teachers, pupils, lecturers, students, shop workers, customers

It caused tens of thousands of avoidable deaths, hundred of thousands with avoidable chronic illness

A permademic of a virus with no durable immunity that makes everyone (or at least most) more susceptible to infections is bad news for public health & economies

At a time of war it becomes a potential enabler & amplifier of bioterrorism attacks, as well as a cover for them 🤔😬 Let's hope governments are smart, and think about moving towards a clean air infrastructure, requiring / recommending HEPA filtration in workplaces & schools & on public transport, putting in place the regulations & production capacity to implement this quickly

It's staggering how many people have been killed by COVID worldwide

The central estimate of the true death toll of the continuing pandemic, using excess deaths (as calculated by The Economist), is 27.3 million

It's hard to imagine how many that is. How a big a pile that is 🧵 So let's make it real for people

I asked ChatGPT to estimate if the COVID pandemic has killed 27.3 million people worldwide, how many swimming pools of would that that pile of bodies fill if piled up?

How much would that pile of bodies weigh?

Re SARS-COV-2, possible endoplasmic reticulum stress (h/t @mrmickme2), and how that can cause mitochondrial dysfunction, I queried chatGPT on how likely it is that ER stress is a significant factor in mitochondrial dysfunction in long COVID

Here is the response 🧵 Mitochondrial dysfunction in long COVID could indeed be related to endoplasmic reticulum (ER) stress, but other potential mechanisms may also contribute to this dysfunction. Mitochondria and the ER are closely linked through cellular signaling and metabolic pathways, and stress

I know the risks, have known this was almost certainly coming for years now, but seeing it already in a 7 yr old, makes me want to be sick😔

I have tried to warn people in my family to keep their children safe & avoid repeated COVID reinfections but they don't want to hear it 😔

https://twitter.com/LadyChuan/status/1826629637780148363

If seven year olds are already being seen with problems like this, and it's due to their SARS-COV-2 infections, what hope will so many kids have, reinfected again & again, at least once a year?

Ok hopefully it will only be a subset

But we don't know how big a subset yet

Severe acute respiratory syndrome coronavirus 2 infection is linked to significant liver injury, emerging from the facilitated entry of the virus into liver cells, including cholangiocytes and endothelial cells, due to increased receptor expression🧵

1/x
wjgnet.com/1007-9327/full… This invasion triggers critical cellular alterations such as mitochondrial swelling, endoplasmic reticulum dilation, and hepatocyte apoptosis.

2/x

Diabetic? Wear a 😷

"hyperglycemic conditions enhanced the viral entry receptor expression, infectivity, & susceptibility of SARS-CoV-2-induced cell death in the blood retinal barrier cells confirming reported heightened pathology in comorbid populations"
journals.plos.org/plospathogens/… "...intranasal exposure (to SARS-COV-2 virus, ie simulating inhalation) not only resulted in SARS-CoV-2 spike (S) protein presence in different ocular tissues but also induces a hyperinflammatory immune response in the retina..."

"Cattle have the potential to act as a mixing vessel for novel IAV generation"

"The avian and human influenza A virus receptors sialic acid (SA)-α2,3 and SA-α2,6 are widely expressed in the bovine mammary gland" 🧵

biorxiv.org/content/10.110… Reason cows fare better than many species?

"duck & human IAV receptors were widely expressed in the bovine mammary gland, whereas the chicken receptor dominated the respiratory tract. In general, only a low expression of IAV receptors was observed in the neurons of the cerebrum"

@CCSDMaskUp @RickABright @GISAID @USDA "A striped skunk was found dead in proximity to deceased Canada geese in late February in Tompkins County"

.cwhl.vet.cornell.edu/article/highly… @CCSDMaskUp @RickABright @GISAID @USDA "apparently healthy" raccoons (Japan though here, not current)

"1,088 serum samples collected from animals captured in ... eradication program over 3 periods in Japan ... during 2005–2009 for a serologic survey of avian influenza virus (H5N1) infection"
ncbi.nlm.nih.gov/pmc/articles/P…

"reviewed studies generally indicate that human norovirus (NoV), Hep A (HAV) and Hep E (HEV) possess a high heat stability. Heating at 70-72 °C for 2 min significantly reduces infectious titers, but often does not result in a >4 log10 decrease"
.pubmed.ncbi.nlm.nih.gov/38290272/#:~:t… "Resistant fractions of viruses may remain infectious in thermal inactivation processes and inactivation of newly discovered or enveloped viruses in thermal food preparation processes should not be assumed without further testing"

ncbi.nlm.nih.gov/pmc/articles/P…

H5N1 virus survival

"viral RNA was detected in few cases in the aquatic fauna and flora, especially in bivalves and labyrinth fish, although these organisms seemed to be mostly passive carriers of the virus rather than host allowing virus replication"

pubmed.ncbi.nlm.nih.gov/22514622/
H5N1 high pathogenicity avian influenza virus survival in different types of water

"Prolonged infectivity of the virus in Baltic seawater (brackish, 7.8 ppt) was also seen."

pubmed.ncbi.nlm.nih.gov/20521724/

@AuDHDeep1 @1goodtern To be fair, I think most of us who are COVID cautious have to deal with people who don't understand why, and they think it's us who have a problem.

Yes, it's typically a problem of understanding of risk, but their problem, not ours! 😆

Most really don't understand the risk @AuDHDeep1 @1goodtern They don't understand the risk to themselves, the risk to their kids, they don't understand they will keep getting reinfected, likely suffering cumulative harms over time as a result. They assume the risk is just to the concerned person at best, & they resent life being limited

BBC: "The Covid pandemic may have impacted brain health in people in the UK aged 50 & over, according to a new study."

You don't say?? Not a surprise when everyone keeps getting infected by SARS-COV-2 that we've known causes brain damage for over 3 years
bbc.co.uk/news/health-67…
COVID causes brain damage

Confirmed by a PhD brain pathology microscopist

https://x.com/DaniBeckman/status/1756117668971880777?t=DCumi8Fg-RqWI2y94inG5w&s=03

Well done #TaylorSwift

Another huge global star making their tours more COVID safe

We need more stars & their management explaining why it's so important to avoid being regularly reinfected by SARS-COV-2

18 February 2024


@taylorswift13 @taylornation13au.lifestyle.yahoo.com/why-taylor-swi… "a music industry source told Yahoo Lifestyle that Taylor has no plans to be seen anywhere but the stage whilst in Australia, nor does she intend on meeting any fans"

Since Covid, her team had to “permanently axe these (backstage meet and greets)
as they pose too much risk”

Adele is wise: “Everyone that I know that I work with has fucking COVID, so it’s a miracle that I haven’t had it yet,” she added. “And I really do love chatting to you, but I don’t want to get sick, I’ll take selfies from a distance or shoot your vid."
nme.com/news/music/ade… Adele: “I might have symptoms and then I can’t do my show and I will be damned if I cancel any more of these shows ... I just can’t risk getting ill. Honestly, my immune system is in the gutter and I want to be close to you and stuff like that, but I just can’t risk it.”

There is a reason that the pandemic's true death toll is running 4x higher than the official death toll.

Long COVID kills

All those strokes, myocardial infarctions, new & exacerbated rapidly progressing dementias that follow COVID infections, & the many other post acute deaths

https://twitter.com/0bj3ctivity/status/1759193207483605140

Long COVID was defined as ALL health harm that follows due to SARS-COV-2 infection. Why? Because SARS-COV-2 is systemic & can harm ANY organ & tissue within body, directly or indirectly
ALL these harms need to be included when weighing the cost of inaction

https://twitter.com/elisaperego78/status/1593559920560918528?t=3I6k6uF0adINroXPJTTAkw&s=19

Long-term risks of respiratory diseases SARS-CoV-2 patients: a longitudinal population-based cohort study

"patients with COVID-19 may have an increased risk of developing respiratory diseases ... RISK INCREASES WITH severity of infection and REINFECTION"

sciencedirect.com/science/articl… "Even during the 24-month follow-up, the risk of asthma and bronchiectasis CONTINUED TO INCREASE. Hence, implementing appropriate follow-up strategies for these individuals is crucial to monitor and manage potential long-term respiratory health issues."