Thread by @drkohilathas

Nigella sativa, also called black cumin or black seeds.

“The herb from heaven" with antioxidative, anti-inflammatory, immunomodulatory, anticancer, neuro and cardioprotective, antidiabetic, metal and toxin chelating, pro-fertility, and anti-COVID-19 effects.

A THREAD 🧵

Nigella sativa is a plant famous for its culinary uses and medicinal properties. It is native to a vast region of the eastern Mediterranean, northern Africa, the Indian subcontinent, and Southwest Asia, and is cultivated in many countries, from Egypt to Pakistan

Ancient herbalists considered N. sativa to be “The herb from heaven."

It is also known as “Prophetic medicine” in the Muslim community because the Prophet Mohammad (PBUH) once stated, “This black cumin is healing for all diseases except death."

The Holy Bible mentions black cumin for its curative properties and designates it as "melanthion" by Hippocrates and Dioscorides.

ncbi.nlm.nih.gov/pmc/articles/P…

N. sativa has even been found in the tomb of the Egyptian Pharaoh Tutankhamun. Ancient Egyptians are thought to have used black cumin as a preservative in the process of mummification, probably due to its antibacterial and insect repellent properties.

academic.oup.com/fqs/article/2/…

N. sativa medicinal properties are due to containing a variety of bioactive compounds such as thymoquinone (TQ), thymohydroquinone, thymol, carvacrol, nigellidine, nigellicine, and α-hederin.

TQ, a terpene, is the most studied bioactive component of N. sativa

The health benefits of N. sativa cover almost every physiological system; this is largely due to its antioxidant properties.

N. sativa has shown to lower ROS, whilst upregulating antioxidant enzymes like superoxide dismutase (SOD) in several studies.

ncbi.nlm.nih.gov/pmc/articles/P…

In one meta-analysis of five studies using 293 human subjects, N. sativa supplementation was shown to have a beneficial role as an antioxidant by improving SOD levels and improving total antioxidant capacity.

ncbi.nlm.nih.gov/pmc/articles/P…

N. sativa (and especially N. sativa oil) has shown anti-inflammatory properties too. In one study, N. sativa oil was shown to reduce IL-6 and IL-1β levels in inflamed fat cells.

ncbi.nlm.nih.gov/pmc/articles/P…

Rats with inflammatory paw swelling given N. sativa oil showed significant improvement in the pro-inflammatory cytokines IL-6, IL-12 and TNF-α in another.

derpharmachemica.com/abstract/chara…

With regards to the brain, N. sativa has shown neuroprotective properties against neuroinflammation and promising results against animal models with a wide range of neurodegenerative diseases.

ncbi.nlm.nih.gov/pmc/articles/P…

This one showed thymoquinone therapy remediating elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives in rats.

nature.com/articles/s4159…

N. sativa and TQ have shown to restore neuronal intracellular antioxidant levels; inhibit ROS generation and associated cell death; decrease brain amyloid-β fragment length; decrease amyloid-β formation and accumulation by downregulating the NF-κB pathway; improve memory....

...increase BDNF; attenuate convulsions as well as protecting against neurotoxicity induced by various chemicals, such as chlorpyrifos (an organophosphate pesticide); dichlorvos (an insecticide); acrylamide and arsenic.

pubmed.ncbi.nlm.nih.gov/30668372/

With regard to cancer, a growing body of research demonstrates that the chemical contents of black cumin seeds are chemopreventive and effective at suppressing unwanted cell growth and inducing cell death.

ncbi.nlm.nih.gov/pmc/articles/P…

N. sativa’s anti-cancer properties have been demonstrated in various cell lines from human breast cancer to kidney cancer and more.

pubmed.ncbi.nlm.nih.gov/30259603/

TQ has shown to also synergise anticancer activity of several standard chemotherapeutic drugs as well as natural chemopreventive molecules such as paclitaxel, 5-fluorouracil, resveratrol and piperine.

ncbi.nlm.nih.gov/pmc/articles/P…

Metabolically, following N. sativa oil treatment, one trial on patients with diabetic kidney disease showed a sig reduction in blood glucose, serum creatinine, blood urea, and 24 h total urinary protein levels and improved kidney function.

pubmed.ncbi.nlm.nih.gov/28098097/

The cardiovascular system may also benefit from the use of N. sativa, both pre-treatment as protection and post-conditioning, improving cardiac function by reducing cardiac injury.

pubmed.ncbi.nlm.nih.gov/31286398/

Plus, a clinical study on patients with mild-to-moderately raised blood pressure using black cumin virgin oil demonstrated positive outcomes on lipid profiles and blood pressure.

aloki.hu/pdf/1504_03104…

Other than the heart, studies have shown ​​N. sativa to have liver-protective, stomach-protective, and lung-protective properties.

ncbi.nlm.nih.gov/pmc/articles/P…

In several preclinical investigations ​​N. Sativa oil and TQ have shown to protect against lung damage induced by various chemicals such as lipopolysaccharide (LPS), bleomycin, cigarette smoke, or nicotine, and cadmium.

pubmed.ncbi.nlm.nih.gov/27696167/

With regards to fertility, N. sativa oil has been shown to significantly improve testicular sperm production, semen parameters, and seminal vesicle development in rats; as well as mediate certain toxin- (insecticide) related effects on reproduction.

pubmed.ncbi.nlm.nih.gov/28669218/

In humans, one study found that N. sativa oil (2.5 mL twice daily p.o. for 60 days) significantly increased sperm quality and functional characteristics of spermatozoa.

pubmed.ncbi.nlm.nih.gov/24680621/

Before you carry on, I must let you know that if you'd like to learn more about black cumin and other supplements, then it's all in the book 👇🏾

The PDF and kindle versions contain clickable reference links, so you can quickly access research papers.

callingouttheshots.xyz

When it comes to female reproductive health, N. sativa has been shown to improve menopausal symptoms and reduce postpartum pain in humans.

ncbi.nlm.nih.gov/pmc/articles/P…

In animal models, the herb has been shown to improve ovarian function in rats with polycystic ovaries, as well as several reproductive hormones and overall reproductive performance in female rats in another study.

ams.uokerbala.edu.iq/wp/wp-content/…

N. sativa’s has also shown that this herb is capable of helping with wound healing, skin disorders, bone regeneration, kidney protection, chelating heavy metals, and even reducing venom-induced acute toxic shock.

pubmed.ncbi.nlm.nih.gov/31847893/

The use of N. sativa aids immune function, too. N. sativa has shown to increase macrophage population; stimulate phagocytic activities of three types of macrophages; enhance antibody production; and stimulate certain subsets of white cells.

sciencedirect.com/science/articl…

A 46-year-old HIV patient treated with a black cumin mixture recovered entirely and remained seronegative for six months.

ncbi.nlm.nih.gov/pmc/articles/P…

In another case report, HIV infection in a 27-year-old woman was entirely sero-reverted after a year of black cumin and honey therapy (60:40, 10 mL thrice day), and three children born after the woman was HIV positive were uninfected.

ajol.info/index.php/ajid…

With regards to COVID-19, the use of N. sativa has been extremely promising.

So far statistically significant improvements have been seen for mortality, hospitalisation, recovery, cases, and viral clearance with its use.

In one randomised-controlled trial of 358 hospitalised patients in Iran, 184 who received treatment with a combination of N. sativa and several other herbal medicines, showed shorter hospitalisation time and improved recovery with treatment.

onlinelibrary.wiley.com/doi/10.1002/pt…

An open-label study with 419 patients in Iraq, 160 of whom were treated with Nigella sativa, showed lower mortality and fewer severe cases with treatment. In this study black seeds were given 40 mg/kg orally once daily for 14 days.

researchgate.net/publication/35…

There is no official dosage information for N. sativa. The most common dosage is 1–3 g per day, with studies ranging from using 40 mg/kg orally once daily to a dessert spoon amount of N. sativa oil applied to affected limbs three times a week.

examine.com/supplements/bl…

The FLCCC has recommended the use of 40 mg/kg daily of N. sativa if ivermectin is not available or added to ivermectin for optimal prevention.

covid19criticalcare.com/wp-content/upl…

A recommended safety tip (applies to all supplements)

https://twitter.com/EcoWitch/status/1633460953164697602?t=xBEIg6S8h1fb5Vf5-T2K5g&s=19

And speaking about ivermectin.

https://twitter.com/drkohilathas/status/1627611483285647360?t=xIfrl0wOgdj-I2Bqv-I6Dw&s=19