Abdulla A. Damluji, MD, PhD Profile picture
Mar 15 β€’ 17 tweets β€’ 3 min read
Outcomes of Bioprosthetic Valve Fracture in Patients Undergoing Valve-in-Valve TAVR: @JACCJournals

Many years of collecting these cases: amazing work @AdnanChatriwala πŸ‘πŸ‘

Summary in 15 short bullets

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1/ This study represents the largest cohort of patients who underwent bio prosthetic valve fracture (BVF) as an adjunct to valve in valve (VIV) #TAVR.
2/ BVF is commonly performed as an adjunct to VIV TAVR, particularly in patients with small surgical valves (30% frequency).
3/ However, institutional volumes of attempted BVF are relatively low, with fewer than 35 hospitals performing 5 or more BVF procedures per year.
4/ In adjusted analyses, in-hospital and 30-day mortality, cardiac death, all-cause death or stroke, and life-threatening bleeding were higher in patients who underwent VIV TAVR with attempted BVF compared with those who underwent VIV TAVR without fracture.
5/ Nevertheless, these differences were numerically smaller and not statistically significant in patients who underwent BVF after THV implantation, compared with patients in whom BVF was not attempted, suggesting that procedural technique plays an important role in safety.
6/ When clinically indicated, BVF should be performed after, rather than before, THV implantation.
7/ BVF in the setting of VIV TAVR optimizes THV expansion and can mitigate PPM, which is associated with higher mortality after VIV TAVR.
8/ However, the longer-term effect of BVF on clinical outcomes remains unknown.
9/ One concern with BVF performed prior to VIV TAVR is the potential for surgical valve leaflet injury causing acute severe valvular regurgitation and hemodynamic compromise for a period of time until a competent THV can be implanted.
10/ Other complications that could be directly linked to BVF, such as annular rupture, aortic dissection, and coronary occlusion, were rare (<1%).

(I have seen this once, @DrMauricioCohen)
11/ Interestingly, despite the higher rate of observed complications in patients with attempted BVF, average procedure time was not higher.
12/ Although it appears that BVF performed after THV implantation is the safer option, the question of whether the smaller hazard observed with this technique could be offset by longer-term clinical benefits needs prospective confirmation.
13/ Prior bench testing has demonstrated that most, but not all, surgical valves can be fractured.
14/ Surgical valves vary greatly in their composition, and the threshold at which a valve fractures is dependent on the composition of the valve, and the size of the balloon being used for BVF, and the balloon pressure required to fracture may exceed 20 atm.
15/ In conclusion: The use of BVF as an adjunct to VIV TAVR with SAPIEN 3 & SAPIEN 3 Ultra valves is associated with a higher risk of mortality, excess bleeding, modest reduction in echocardiographic valve gradient, and gain in valve area, when compared with no fracture.
Of course: I made another mistake:

Amazing work by Dr. @akcmahi

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More from @DrDamluji

Mar 16
When you treat stable disease in older adults >75, remember most trials did not include this population. Here are the trials:

ECSS
CASS
RITA-2
VA Cooperative Study
Defer
SOS
MASS-II
FAME-2
Courage
Stick
Bari-2D
ORBITA
Freedom
Ischemia
Ischemia-CKD
-
Last column ImageImage
Only the TIME-investigators enrolled 305 patents >75 years of age and have CCSC class 2 or more.

How many older adults with stable disease have you treated? Many!

Older adults are under represented in trials, but disproportionately affected by CVD.
Sorry - autocorrection -

* Stich Trial
Read 4 tweets
Mar 16
Evaluation and Management of Pulmonary Hypertension in Noncardiac Surgery: A Scientific Statement From the American Heart Association: @CircAHA

Here are few points to summarize

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1/ Pulmonary hypertension (PH) is a group of disorders that result in an elevation in blood pressure in the pulmonary arteries (mean pulmonary artery [PA] pressure [mPAP] >20 mm Hg) and is associated with an increased risk of death.
2/ PH is increasing in prevalence due to an aging population, rising prevalence of heart and lung disease, and improved PH survival with targeted therapies.
Read 21 tweets
Mar 15
Management of Stable Angina in the Older Adult Population: @CircIntv

- This time I get to summarize our work led by my friend @MichaelGNanna

20-point summary 🧡

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1/ Stable Ischemic Heart Disease (SIHD) is a major cause of morbidity, mortality, and disability in older adults, with those aged β‰₯75 making up 30% of patients affected in the US.
2/ Medical therapy is the preferred initial management option for most patients with stable SIHD, with revascularization reserved for high-risk anatomy or breakthrough symptoms.
Read 22 tweets
Mar 14
Anticoagulation Strategies in Non-Critically Ill Patients Hospitalized with COVID-19: A Randomized Clinical Trial: @JACCJournals

From the FREEDOM COVID Anticoagulation Strategy Randomized Trial Investigators

Here is summary πŸ‘‡πŸ‘‡πŸ‘‡
⚑️In this large-scale randomized trial, the aim was to compare the safety and effectiveness of low-molecular-weight heparin and direct-acting oral anticoagulant with standard thromboprophylaxis in non-critically ill hospitalized patients with COVID-19.
⚑️Difference between groups in the incidence of the 30-day primary outcome in patients treated with therapeutic-dose anticoagulation compared with prophylactic-dose anticoagulation did not reach statistical significance.
Read 8 tweets
Mar 13
Atrial Fibrillation Occurring During Acute Hospitalization: A Scientific Statement From the American Heart Association: @CircAHA

AHA Statement from out council: @AHA_AcuteCVCare

Here is a summary πŸ‘‡πŸ‘‡πŸ‘‡
1. Acute management of atrial fibrillation (AF) should be tailored to the patient, underlying structural substrates, and contextual triggers.
2. The management goals are to optimize hemodynamics, alleviate patient symptoms, and reduce short and long-term risks of thromboembolism.
Read 22 tweets
Mar 13
Superficial Radial Artery - Atypical Alternative to Radial Access: @JACCJournals

This is fun!

6 point summary

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1/6: The superficial radial artery (SRA) is a rare anatomical variant with a 0.5% to 1% incidence rate.
2/6: When encountering a weak or absent radial pulse, check the lateral dorsal surface of the wrist for the SRA (Figure 1).
Read 8 tweets

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