Share this page!

Paul Maidowski Profile picture
Twitter logo
Mar 15 • 8 tweets • 3 min read
A thread on the risk of genetic recombination of rabies virus (lyssavirus) with SARS-CoV. RABV is airborne; if it picks up Omicron-grade immune evasion, to lower infectious viral load, chains of infection become untraceable given a long incubation time.

Real-life zombie party.
Fun meme: makes us look like adventure park tour operators. We only alert governments to the need to deliver effective policy.

No magic, just hard work.

Research and translation (for all to understand) takes time; I appreciate occasional coffee support. patreon.com/paulmaidowski
Data academic.oup.com/jtm/advance-ar…
Comical elements used to get around people's subsconscious mental barriers.

IF allowed to occur, this scenario would be horrific. Is it possible? Quite. As support, research #Mpox, a pandemic that could possibly owe to genetic recombination with SARS-CoV.
Some details in the Q&A here.
Background/links mpox:
Twitter structure can be confusing or even unnavigable to many. - Thread starts here.
Also, should you support me? I think so, much appreciated. But frankly some others, @Saltykid41, are much more deserving: do consider supporting her.

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Paul Maidowski

Paul Maidowski Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @_ppmv

Paul Maidowski Profile picture
Mar 16
1. Where is the art of COVID?

Project alert! Good things on the way, perhaps @BabaBrinkman-grade scientific rap: Idea is a track on molnupiravir, a public health risk since the (useless) drug can create supermutated variants and exacerbate the pandemic.

Might do this. DM open🔥
2. Molnupiravir background.
3. Previous @BabaBrinkman rap: I shared some on climate/COVID, but leave you to discover yourself.

Great format for scicomm.

Perhaps more important, ask folks younger than us. I think @nephologue used one of Baba’s tracks in atmospheric science class?
Read 10 tweets
Paul Maidowski Profile picture
Mar 16
Good news! XBB.1.5 now classified as VoI. Criteria for VoC classification updated (=>new Greek letter)

Appreciate great work by volunteers. Now it's time to professionalize: Names matter in politics and coordinating public responses.

States need to deliver sufficient resources.
Quality memes 🤣 ImageImage
Criteria: this only took a several minutes and multiple clicks / downloads. By WHO's labyrinthine standards user-friendly! who.int/publications/m…
Read 4 tweets
Paul Maidowski Profile picture
Mar 16
1. Azvudine. Requires medical supervision and competent governance. It's no free-pass to end COVID-19. (Only share with this context.)

Fosun and Genuine Biotech donated ~400,000 bottles of Azvudine tablets worth RMB 100 million to rural counties in China. prnewswire.com/news-releases/…
2. This overview of COVID-19 antivirals for patients with chronic kidney disease notes that Azvudine may be used also for patients with HIV or CKD and COVID-19 coinfection. frontiersin.org/articles/10.33… Image
3. Nucleoside reverse transcriptase inhibitor (NRTI) with broad-spectrum antiviral activity against HIV,
HCV, EV71, and HBV infection that modulates the expression of P-glycoprotein (P-gp). Also effective against SARS-CoV-2. ImageImageImageImage
Read 7 tweets
Paul Maidowski Profile picture
Mar 15
Two types of systems thinking.

One completely irrational. The other rational—or so we think.

(1) I must admit watching systemic failure live makes it easier to apply for $ for ideas to stop total systemic failure. (2) 1-10% that we (I) are deluded, and I mix up the ir/rational. Image
Not always smoothly, but reality is forcing folks to get real.

Decarbonization by design or disaster?

We have been trying to warn you all for three years and counting.
If you're remotely aware of LongCOVID, read this timeline attentively.

You can read current COVID-19 incidence data as (order of magnitude) 1:1 LC incidence, because no one is collecting data anymore.

10-20% LC per infection, vs. 10-25 fold undercount for almost the past year. Image
Read 5 tweets
Paul Maidowski Profile picture
Mar 15
A. #LongCovidAwarenessDay.

Time for people with LongCovid to speak. Here just one high-level lesson I can add:

Use precise medical language to access care. Demand change from an establishment that hung you out to dry.

Eg, it's SAND, equivalent to HAND in HIV, not 'brain fog'.
B. Beware, few understand SARS viral persistence as cause of LongCovid (etiology). IDK why!

MDs then treat symptoms, not causes. Be sure not to waste time you don't have.

Demand a viral load test. HIV T cell depletion tests can diagnose Long Covid, just as it did for Long SARS. Image
C. Always teach the relevant scales and dynamics.

65 million patients!?!

That's twice as many as people living with HIV, and you're treated far worse: often gaslit, no POC T cell test, people mostly ignore you.

On the AIDS timeline, we are in the early 1980s.

Read this again. Image
Read 11 tweets
Paul Maidowski Profile picture
Mar 15
1. Do we see an emerging pattern of three overlapping SARS waves, one each 28 days, circling the globe?

Open question to reality-check @RealCheckMarker, whose excellent pandemic observations I often share/comment.

Three-month pattern in most data: check ✅

Details matter. Why?
2. The high-level prediction to reality-check.

Feel free to bring data; Twitter is for learning and this one is vital to effective policy.

We won’t eliminate SARS-CoV - or even just keep society in good health - if we don’t understand its basic dynamics.
3. Chinese speakers: integrate China and the rest of the world, incl. India to reflect the next big ship XBB.1.16.

We are three months out from China's big wave; IF Azvudine didn't work, we would expect the next wave to start soon.
chinacdc.cn/jkzt/crb/zl/sz…
ImageImage
Read 15 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

Send Email!

:(