Thread by @drkohilathas

Astragalus

A herb with immune-boosting, anti-cancer, cardio-protective, anti-aging, hair re-growing, nerve growing, cognition-protecting, anti-inflammatory, and pro-male fertility properties.

A THREAD 🧵

Astragalus membranaceus is one of the fifty fundamental herbs in traditional Chinese medicine, and has been used as a medicine for more than 2000 years.

In vitro and in vivo studies have shown that this medicinal root contains many compounds with health and protective properties, including antioxidant, anti-inflammatory, immunostimulant, anti-aging, neuroprotective, anti-cancer, and anti-diabetic effects.

sciencedirect.com/science/articl…

Astragalus membranaceus has been shown in studies to stimulate T and B lymphocytes and secrete lymphocyte cytokines such as IFN- and various interleukins to improve macrophage function and phagocytosis.

link.springer.com/article/10.100…

It has also been shown to help improve the mucosal immune system by increasing IgA secretion and proliferating intestinal mucosa, as well as protecting and proliferating the activity of NK to fight other disease cells.

sciencedirect.com/science/articl…

This root also contains a compound (TA-65) that increases telomerase activity and has age-reversal and protective effects in immune system cells.

spandidos-publications.com/10.3892/etm.20…

Astragalus membranaceus has been shown to protect the pancreas from autoimmune-linked cell death through the mechanisms of anti-oxidation, immunomodulation, anti-inflammation, and anti-apoptosis, as well as by helping to balance Th1 and Th2 responses.

hindawi.com/journals/ecam/…

Various compounds of Astragalus membranaceus have also been shown to reduce various organ-specific inflammation, from bowel inflammation, kidney inflammation, and uterus inflammation to cardiac endothelial inflammation.

spandidos-publications.com/10.3892/etm.20…

Astragaloside IV (AST) is purified from the root of Astragalus membranaceus, one study of a mice model with myocarditis showed AST to have improved mouse survival times and improved cardiac scarring.

dovepress.com/astragaloside-…

AST has also been shown to protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular endothelial dysfunction, and promote angiogenesis.

dovepress.com/astragaloside-…

With regards to neurology, AST and Astragalus membranaceus have been shown to improve neurological deficits and reduce the areas of cell death in stroke studies.

pubmed.ncbi.nlm.nih.gov/28303172/

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Low-dose AST has been related to the growth and division of neural stem cells.

pubmed.ncbi.nlm.nih.gov/27034688/

Another study found that topical administration of AST in mice leads to hair regrowth and “may be used for treatment of hair diseases such as alopecia, effluvium and hirsutism.”

ncbi.nlm.nih.gov/pmc/articles/P…

Animal and in vitro studies have also suggested that Astragalus membranaceus may also help male infertility by improving sperm parameters.

ncbi.nlm.nih.gov/pmc/articles/P…

In double-blind study included 18 members of the Polish Rowing Team, 500 mg Astragalus Membranaceus Root restored the immunological balance in strenuously trained athlets through a stabilization of NK and Treg cells with a positive trend in Th1 response.

jissn.biomedcentral.com/articles/10.11…

Astragalus-containing traditional Chinese medicine (TCM) is widely used as adjunctive treatment to platinum-based chemotherapy (PBC) in patients with advanced gastric cancer (AGC) in China.

Evidence (low to moderate) has shown astragalus-containing TCM combined with PBC had better efficacy and less side effects in the treatment of AGC.

frontiersin.org/articles/10.33…

The daily dose recommended in China, 9–30 g, is recognised as safe when used appropriately.

The standard dose for AST is 5–10 mg.

examine.com/supplements/as…