Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy from 2011, #DCVaxL with #PolyICLC #Glioblastoma #GBM

aacrjournals.org/clincancerres/…
#DCVaxL & #PolyICLC #TLR3Inhibitor as adjuvant, have been an impressive combination since 2011:

Results: DC vaccinations are safe and not associated with any dose-limiting toxicity.
The median overall survival from the time of initial surgical diagnosis of glioblastoma was 31.4 months, with a 1-, 2-, and 3-year survival rate of 91%, 55%, and 47%, respectively.
Patients whose tumors had mesenchymal gene expression signatures exhibited increased survival following DC vaccination compared with historic controls of the same genetic subtype.
Tumor samples with a mesenchymal gene expression signature had a higher number of CD3+ and CD8+ tumor-infiltrating lymphocytes compared with glioblastomas of other gene expression signatures (P = 0.006).
Conclusion: Autologous tumor lysate–pulsed DC vaccination in conjunction with TLR agonists is safe as adjuvant therapy in newly diagnosed and recurrent glioblastoma patients.
Our results suggest that the mesenchymal gene expression profile may identify an immunogenic subgroup of glioblastoma that may be more responsive to immune-based therapies. Clin Cancer Res; 17(6); 1603–15. ©2010 AACR.

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More from @eastvillagetwt

Mar 20
Granted: Commercial manufacturing license (MIA) at Sawston, for CDMO Advent at the $NWBO owned factory for manufacturing #DCVaxL, it’s successful #cancervaccine for #GBM & any solid tumor ultimately.

Next step, Marketing Approval, BLA.

cms.mhra.gov.uk/mhra/mia/uk-mi…
Background:

Northwest Biotherapeutics Announces Filing of Application for License for Commercial Manufacturing at Sawston, UK Facility

From July 6, 2022

nwbio.com/northwest-biot…
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients w/Newly Diagnosed & Recurrent Glioblastoma: Phase 3 Prospective Externally Controlled Cohort Trial | JAMA Oncology $NWBO #DCVaxL #Phase3

jamanetwork.com/journals/jamao…
Read 7 tweets
Mar 20
Commercial manufacturing license for designated contract manufacturing manager for Sawston, the $NWBO factory for manufacturing #DCVaxL, it’s successful #cancervaccine for solid tumors, first for #GBM

Next step, commercial marketing approval, BLA, etc.

cms.mhra.gov.uk/mhra/mia/uk-mi
Background:

Northwest Biotherapeutics Announces Filing of Application for License for Commercial Manufacturing at Sawston, UK Facility

From July 6, 2022

nwbio.com/northwest-biot…
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients w/Newly Diagnosed & Recurrent Glioblastoma: Phase 3 Prospective Externally Controlled Cohort Trial | JAMA Oncology $NWBO #DCVaxL #Phase3

jamanetwork.com/journals/jamao…
Read 6 tweets
Mar 19
Not just the Saudi deal, see this short thread for more and worse deals, involving what looks like blackmail, IMHO, with Qatar.
DEMOCRATS WANT ANSWERS ABOUT JARED KUSHNER’S VERY SHADY MIDDLE EAST DEAL (NO, NOT THE SAUDI ONE!)

This is the one involving a miraculous financial bailout for his family, Qatar, and his White House work in the Middle East.

vanityfair.com/news/2022/12/j…
Top senator seeks answers over Qatar link to $1.2bn Kushner property rescue

This article is more than 5 months old
Senate finance panel chair sends detailed questions to financial firm on deal for property owned by then White House aide’s family

theguardian.com/us-news/2022/o…
Read 5 tweets
Mar 18
Now Tim Scott wants to embrace the likely false notion that COVID was manufactured and released intentionally. That leads to war with China. That is irresponsible absent evidence in reality. It's destructive, not constructive and embraces reactionary emotion, not rationality.
Whatever the case, all of us are against fentanyl being illegally smuggled and distributed and in fact Biden has been very effective at interdicting it at the border. Republicans use the seizures as if they are evidence of lack of enforcement, which is an absurdity.
We want all of our brothers and sisters in all states, but ESPECIALLY the red states, to stay off fentanyl and all addictive and destructive drugs and hopefully they can start then to see how insane GOP politics have become. They say one thing but mean the other thing.
Read 4 tweets
Mar 13
Federal Reserve Board - Federal Reserve Board announces it will make available additional funding to eligible depository institutions to help assure banks have the ability to meet the needs of all their depositors federalreserve.gov/newsevents/pre…
Fed will make advances to any federally-insured depository institution against collateral valued at par, for up to one year at OIS+10bps.
Term sheet for Federal Reserve funding: federalreserve.gov/newsevents/pre…
Read 4 tweets
Nov 30, 2022
@matthwilliams @NWBIO @braintumourrsch @BrainTumourOrg Dude, your conflict of interest is all over you and this criticism. Let the regulators do their jobs. You focus on your patients and BUSINESS interests. Let the regulators, patients and market decide what they would prefer. You’re disgracing yourself in the field.
@matthwilliams @NWBIO @braintumourrsch @BrainTumourOrg Let's recall that Optune costs £20,000 per month in the UK, or £240,000 per year, as long as the patient lives, an incredibly expensive treatment, which is why the NHS only covers it for a limited group of patients. It's burdensome, expensive & requires 18 hrs a day compliance.
@matthwilliams @NWBIO @braintumourrsch @BrainTumourOrg Call for NHS to fund £240,000 cancer treatment Optune

bbc.com/news/uk-englan…

I can see why you'd prefer such an expensive treatment, forever, over a treatment that could make potentiatlly he same number of patients free from treatment at all.
Read 9 tweets

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