Thread by @DrJackKruse

1. @hubermanlab your question to Attia about Progesterone/E2 = E2 regulate sexual receptivity in the mammals by acting on neurons that converge POMC neurons in the arc. nuc - project medial preoptic nucleus (MPN). E2 rapidly activates these neurons to release β-endorphin =… twitter.com/i/web/status/1…

2. When this relay is broken then vasopressin release altered in HPA and this causes PMS. Progesterone reverses it because it allows water resorption, but VP remains defective with chronic PRG.

3. PMS is a light stress effect in women due to defects in POMc that alters ADH release. These women all get signs of CSF hypotension because they are dehydrated centrally. #mitochondriacwisdom

4. For Twitter fans this comes up at the 1:09 hour of the @hubermanlab Attia podcast. It is brain surgery without a scalpel.

5. Menopause symptoms are vasomotor = hypothalmic deficits = POMc story. Women who get adequate solar exposure rarely get menopause symptoms. Biochemical focus never gets the light physics of hormones.

6. Attia treats his ladies with Progesterone. I treat mine with UVA-IR-A light with fire. No drugs needed when you understand how to use the compound pharmacy in your own body. Pic below in 55 yr old female no symptoms for 5 yrs.

7. Attia correct on the synthetic hormones in WHI but the real reason why MPA sucked is how it affected 380 nm light relays in central retinal pathway into HPA and in ovary/vagina.

8. His point on the investigators and ARR spot on. Women have been screwed by that study. Another critique he did not mention was no light controls, and the route of estrogen matters due to how sex steroids are controlled by UV light.

9. Women who cannot tolerate progesterone are always light stressed due to POMc/ACTH. Use IUD's/PG horrible in those women in my opinion because of SCN effects on ovary/uterus.

10. @ 1:26 get to men. GnRH is 100% related to POMc light stress. They miss this 100%. Neurons in the hypothal. arc nuc that co-express kisspeptin, neurokinin B & dynorphin are essential for mammalian reproduction as key regulators of gonadotropin-releasing hormone secretion

11. Number one way to lower SHBG? UVB and UVA light. No one covered it.

12. POMc has a huge effect on ACTH = insulin and BG. These lower T because of the melanin issue in the HPA.

13. @ 1:36 Attia hammers the muscle BG testosterone issue but whiffs on how light stress drives BG and this is why he falsely believe you need hypertrophied muscles and thinks this is great for longevity= NOT mitochondriac wise

14. Tweet 13 shows you how biochemical myopia is a half-truth and leads to a full lie eventually. Nothing in the supercentenarian data supports muscle mass or strength as a key to their long life. Quantum biology 101.

15. Testosterone affects RBC smears is and HPA volume is the way I assess it. I do not like clomid because of what it does to peripheral smears. It is a synthetic drug that ruins the GnRH pacemakers.

16. The link of aromatase to fatmass = leptin melancortin pathway problem. Again they miss the real problem. POMc.

17. At 1:53 Attia correctly mentions the issue with clomid which is the sterol pathways dysregulation. UVB/UVA light loss is why this happens and people remain unaware that a lack of UV light dysregulates cholesterol synthesis in the skin/liver. @hubermanlab

18. tweet 17 should have been 1:43 not 1:53.

19. Use of sunscreen completely ruins most of this BHRT talk too FYI and Attai loves his suncreams.

20. No mention of "junk/garden maintenance" either or the effect of PBM on andropause or menopause. Too bad.

21. If you use sunscreen you should never use Clomid or any synthetic hormone drug. NEVER. #Mitochondriacwisdom This was not covered.

22. This talk should be educational for the public. There are many layers of understanding and you need to marry your biases and goals to the docs you hire. Centralized vs decentralized medicine on display.

23. 2:00 spot: No realization that receptor sensitivity is driven by light via proton and electron tunneling? Attia goes straight for the bro-science response of training and diet. SMH.

24. Attia makes the statement when he looked best his T was in shitter due to over training at 2:01.......no mention why. Done under light stress. Total whiff. That is how many guys die looking great and killing their stem cell reserves.

25. The entire cholesterol take 2:03-26 and particle fever take just had me SMH because every single issue here = Non-linear optical effect of ferroelectric currents in endothelium. Just nothing there and nothing linked to Becker. All biochem crap.

26. Attia needs a primer on cholesterol and mitochondrial membranes. Inner mit membrane has a bacterial origin therefore cholesterol POOR in eukaryotes for a biophysical reason.

27. Number one thing that reduces APO B in humans?

28. Number one thing that raises it? A light environment of a lack of UV with a ton of BLUE LIGHT. When you are undereducated on light you blame food/exercise. And the food is still a light story = photosynthesis. LOL.

29. Attia seems clueless on the purpose of the liver with respect to the sun. This is why it converts Vitamin D to the active form. Sunlight massively reduces cholesterol irresepctive of diet because of its control of POMc and this is why saturated fats are tropical fats. Epic… twitter.com/i/web/status/1…

30. his opinion is in the biochemical weeds because there is zero understanding of how light controls the entire show, especially in the liver.

31. This is why he pushes statins........clear as day listening to this. Centralized vs decentralized MD right there.

32. The ending discussion on peptides just killed me. Just no understanding about Becker's work on regeneration and why stem cells and peptides are centralized healthcare failures.

33. I appreciate the peek inside Attia's head but it tells me how far away we are from good health care. It is sobering how off-track our thinking is in Ivory Tower care.

34. What did I feel like listening to this? You had something to hide
Should have hidden it, shouldn't you?
Now you're not satisfied
With what you're being put through
It's just time to pay the price
For not listening to advice
And deciding in your youth … twitter.com/i/web/status/1…

35. Listening to centralized ideas cost us a loss of our most valuable resource.