Emmanuel Profile picture
Mar 22 4 tweets 3 min read
AUTOIMMUNE diseases and METABOLIC DYSREGULATION after COVID-19 syndrome

mdpi.com/1999-4915/15/3… Image
2) 😨
"The authors identified a significantly higher risk within the first 6 months after COVID-19 for the development of rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, dermatopolymyositis, systemic sclerosis, Sjögren syndrome, Image
3) ... mixed connective tissue disease, Behçet’s disease, polymyalgia rheumatica, vasculitis, psoriasis, inflammatory bowel disease, celiac disease and type 1 diabetes mellitus" 😨 Image

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More from @ejustin46

Mar 24
CHROMATIN ?
What does it mean ?

For those who wants some explanations more layman terms, I recommend this article

COVID-19 infection can change structure of our genes: Study
m.economictimes.com/news/science/c…
2) To go a little bit deeper on this topic

Researchers identify the mSWI/SNF chromatin remodeling complex as a host-directed drug target for SARS-CoV-2 infection
news-medical.net/news/20230314/… Image
3) And for those searching additional info ... 😏

"Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection | Nature Genetics"
nature.com/articles/s4158…

Fig. ATPase activity-competent mSWI/SNF complexes are essential for SARS-CoV-2 infection. Image
Read 4 tweets
Mar 24
ONE of the most INTERESTING STUDY of the genetic LANDSCAPE of circulating VARIANTS !

"In-depth genetic characterization of the SARS-CoV-2 pandemic in a two-year frame in North Macedonia using second and third generation sequencing technologies"
frontiersin.org/articles/10.33… Image
2) Fig. Number of SARS-CoV-2 cases in the period January 2020 – December 2021 and SARS-CoV-2 incidence by age groups and sex. ImageImage
3) Fig. Number of death cases on a weekly basis in a two-year span. ImageImage
Read 8 tweets
Mar 24
KEY STUDY !

SARS-CoV-2 restructures host chromatin architecture
nature.com/articles/s4156…

(Def. Chromatin refers to a mixture of DNA and proteins that form the chromosomes found in the cells of humans and other higher organisms.) Image
2) "Host chromatin alterations resonate with the dichotomic deregulation of immune gene expression in COVID-19: weakened IFN responses accompany increased PIF gene expression"

Fig. SARS-CoV-2 restructures the host 3D genome. Image
3) Fig. Compartment A weakening by SARS-CoV-2. Image
Read 7 tweets
Mar 23
Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein
nature.com/articles/s4146…
Fig. Schematic of the structural transition of prefusion spikes. Image
2) Fig. Differences in structural dynamics between Wuhan (D614) spike and G614 spike. Image
3) Fig. Conformational evolution of spike. Image
Read 7 tweets
Mar 23
COVID-19 Genome Surveillance: A Geographical Landscape and Mutational Mapping of SARS-CoV-2 Variants in Central India over Two Years
medrxiv.org/content/10.110… Image
2) "This study identified 104 different SARS-CoV-2 pango-lineages classified into 19 clades. We have also analysed the mutation profiles of the variants found in the study, Image
3) which showed eight mutations of interest, including L18F, K417N, K417T, L452R, S477N, N501Y, P681H, P681R, and mutation of concern E484K in the spike glycoprotein region." Image
Read 4 tweets
Mar 23
DISTINCT evolutionary pathways of OMICRON subvariants

"Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2"
biorxiv.org/content/10.110… Image
2) "We found two distinct evolutionary pathways and three newly identified mutations that shaped the virological features of these subvariants. One phenotypic group exhibited a discernible decrease in viral receptor affinities, Image
3) but a increase in resistance to antibody neutralization, as exemplified by CH.1.1, which is apparently as resistant as XBB.1.5. In contrast, a second group demonstrated a substantial increase in viral receptor affinity but only a moderate increase in antibody evasion, as BN.1. Image
Read 4 tweets

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