2) 😨
"The authors identified a significantly higher risk within the first 6 months after COVID-19 for the development of rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, dermatopolymyositis, systemic sclerosis, Sjögren syndrome,
Researchers identify the mSWI/SNF chromatin remodeling complex as a host-directed drug target for SARS-CoV-2 infection news-medical.net/news/20230314/…
ONE of the most INTERESTING STUDY of the genetic LANDSCAPE of circulating VARIANTS !
"In-depth genetic characterization of the SARS-CoV-2 pandemic in a two-year frame in North Macedonia using second and third generation sequencing technologies" frontiersin.org/articles/10.33…
2) Fig. Number of SARS-CoV-2 cases in the period January 2020 – December 2021 and SARS-CoV-2 incidence by age groups and sex.
3) Fig. Number of death cases on a weekly basis in a two-year span.
Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein nature.com/articles/s4146…
Fig. Schematic of the structural transition of prefusion spikes.
2) Fig. Differences in structural dynamics between Wuhan (D614) spike and G614 spike.
COVID-19 Genome Surveillance: A Geographical Landscape and Mutational Mapping of SARS-CoV-2 Variants in Central India over Two Years medrxiv.org/content/10.110…
2) "This study identified 104 different SARS-CoV-2 pango-lineages classified into 19 clades. We have also analysed the mutation profiles of the variants found in the study,
3) which showed eight mutations of interest, including L18F, K417N, K417T, L452R, S477N, N501Y, P681H, P681R, and mutation of concern E484K in the spike glycoprotein region."
DISTINCT evolutionary pathways of OMICRON subvariants
"Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2" biorxiv.org/content/10.110…
2) "We found two distinct evolutionary pathways and three newly identified mutations that shaped the virological features of these subvariants. One phenotypic group exhibited a discernible decrease in viral receptor affinities,
3) but a increase in resistance to antibody neutralization, as exemplified by CH.1.1, which is apparently as resistant as XBB.1.5. In contrast, a second group demonstrated a substantial increase in viral receptor affinity but only a moderate increase in antibody evasion, as BN.1.