Thread by @drkohilathas

Coenzyme Q10

The coenzyme with antioxidant, energy-boosting, anti-inflammatory, immunomodulatory, neuroprotective, cardiovascular protection, anti-clotting, and fertility aiding properties.

A THREAD 🧵

Coenzyme Q10, also known as CoQ10 or ubiquinol, is a fat-soluble compound that naturally occurs in all respiring animal cells and is primarily found in the mitochondria.

Other than being vital in cellular energy production, CoQ10 also functions as an antioxidant (mainly protecting cell membranes and plasma lipoproteins), working closely with vitamins C and E.

pubmed.ncbi.nlm.nih.gov/17482527/

The types of cholesterol that are normally referred to as “bad” may need a name change, as they are the ones that primarily carry CoQ10 in the blood, and it is believed that CoQ10 is capable of preventing them from oxidation.

ift.onlinelibrary.wiley.com/doi/abs/10.111…

Statins, a drug used to treat high levels of "bad" cholesterol, also reduce levels of CoQ10, and CoQ10 has been considered a potential candidate for the treatment of statin-induced muscle disease.

ift.onlinelibrary.wiley.com/doi/abs/10.111…

CoQ10, and has been considered a potential candidate for the treatment of various other conditions, including cardiovascular, neurodegenerative, neuromuscular, mitochondrial, and fertility problems.

ift.onlinelibrary.wiley.com/doi/abs/10.111…

Supplementing with CoQ10 has shown promise, helping to activate mechanisms controlling mitochondrial biogenesis and delay cellular ageing (senescence).

pubmed.ncbi.nlm.nih.gov/19960455/

pubmed.ncbi.nlm.nih.gov/24124769/

Experimental studies in animal models suggest that CoQ10 may protect against neuronal damage caused by ischemia, atherosclerosis, and toxic injury.

pubmed.ncbi.nlm.nih.gov/16621054/

CoQ10 supplementation has also been shown to decrease pro-inflammatory cytokines and inflammatory markers in the elderly with low CoQ10 levels.

pubmed.ncbi.nlm.nih.gov/28179205/

CoQ10 has also been shown to help patients with chronic heart failure, improving symptoms and reducing major cardiovascular events.

pubmed.ncbi.nlm.nih.gov/25282031/

CoQ10 deficiency syndrome is a spectrum of conditions where unfavourable mutations occur in genes and/or proteins indirectly or directly involved in the biosynthesis of CoQ10.

ncbi.nlm.nih.gov/pmc/articles/P…

Those with primary CoQ10 def syndrome can suffer with a wide range of conditions including kidney diseases, strokes, cerebellar ataxia, spasticity, peripheral neuropathy, intellectual disability, movement disorders, exercise intolerance and muscular weakness.

Sound familiar?

In individuals with primary CoQ10 deficiency, early treatment with high-dose oral CoQ10 supplementation has been shown to improve the pathological disease state, limit the progression of brain damage, and help recover kidney damage.

pubmed.ncbi.nlm.nih.gov/18579827/

The elderly (and especially the elderly that undergo low levels of physical activity - with related low muscle mass) have also shown more likely to have low levels of CoQ10.

pubmed.ncbi.nlm.nih.gov/24384733/

Low plasma CoQ10 levels have been associated with acute influenza, viral papilloma infections, and sepsis; this is another reason why the elderly may be more susceptible to infection.

immunologyresearchjournal.com/articles/coenz…

SARS-CoV-2 also seems to damage mitochondrial health. In one study, COVID-19 pneumonia patients in Italy found that the infected monocytes displayed alterations in mitochondrial functions and disrupted bioenergetics.

embopress.org/doi/full/10.15…

Luckily, CoQ10 may come to our aid here.

Melatonin can help.

https://twitter.com/drkohilathas/status/1638163693715308544?s=20

And so can ketones.

https://twitter.com/drkohilathas/status/1635253419844980736

In another small study it was shown that targeted mitochondrial therapy with CoQ10 supplementation and spa rehabilitation may improve mitochondrial health and accelerate the recovery of the patients after COVID-19.

pubmed.ncbi.nlm.nih.gov/34967652/

If you like my threads, then you may find if of interest to know that I source the information for it from my recently released book.

People are seeming to enjoy it!

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callingouttheshots.xyz

An in vitro study showed that CoQ10 attenuated platelet aggregation and thus clot formation induced by SARS-CoV-2 spike proteins, likely due to its strong antioxidative ability.

mdpi.com/1422-0067/23/2…

CoQ10 levels in seminal fluid are considered an important biomarker of healthy sperm.

With regards to male fertility, it has been shown that CoQ10 improves semen parameters in the treatment of idiopathic male infertility.

pubmed.ncbi.nlm.nih.gov/25308577/

Supplementation of CoQ10 (200–300 mg/day) in men with infertility has been shown to improve sperm concentration, density, motility, and morphology.

pubmed.ncbi.nlm.nih.gov/22704112/

This has also been reflected when CoQ10 has been supplemented with vitamins C and E.

pubmed.ncbi.nlm.nih.gov/24704922/

A 2015 study showed that suboptimal levels of CoQ10 can lead to egg deficits and age-associated declines in fertility.

ncbi.nlm.nih.gov/pmc/articles/P…

In women undergoing IVF, pretreatment with CoQ10 was shown to improve ovarian response to stimulation and embryological parameters.

ncbi.nlm.nih.gov/pmc/articles/P…

The standard dose for CoQ10 is generally 90 mg for a low dose and 200 mg for the higher dose, but doses as high as 1200 mg daily and 3000 mg per day have been used in clinical trials.

examine.com/supplements/co…

Since CoQ10 is mainly distributed in high-energy-demanding tissues, animal hearts and livers represent the richest source of this bioactive molecule, with a content between 30 and 200 mg/kg

diposit.ub.edu/dspace/bitstre…

Since the efficiency of absorption decreases as the dose increases, taking extremely high doses increases the treatment cost without having any impact on treatment efficacy. 90 mg tends to be the most cost-effective dose.

examine.com/supplements/co…

But if you are thinking of taking higher doses, it is recommended that you split this into several doses throughout the day.

diposit.ub.edu/dspace/bitstre…

And as CoQ10 is a lipidic medium, it is recommended that you take it with meals containing fat.

diposit.ub.edu/dspace/bitstre…