How do you explain Mitogen Activated Protein kinase in layman's terms? How do you explain that you can guarantee that cell is done when you play with this cascade? How do you explain the crosstalks with the lysosome-regulating mTOR complex (mTORC(1/2) or the interactions with AKT
(serine/theronine kinases), for example, and get across what is fact in a layman-friendly way? "That's a 6 for cancer lottery and now just let it surprise you when and where because we can't unravel the biodistribution for you in more detail?"
I am open to suggestions and ideas!
[I think this question is mainly addressed to all those who should know so much more than I do:
Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity
Imagine: You want to sell a patent based on LNP technology. Would you then ignore your previous research that dealt with micro RNAs in cancer? Would you keep quiet that you knew very well that these micro RNAs would be affected after the transfection shots and lie about it?
Funfact: and another nice reminder. I liked the graphic @drkohilathas used here to make the point why you don't screw with crosstalks without thinking it through the end.
I really pray that Rapamycin will work. It could be a powerfull tool in the fight of that what we expect to see the coming years. As you can see in the tweet of @drkohilathas: If you have a drug that works it has multiple positive effects on diverse
crosstalks and won't dysregulate the nat. way of the crosstalks in screwing for example the e2f, cdk2 / 4/6 uncontrolled and trigger absolut spontanous events.
Let's break another cheese with the mouse @Jikkyleaks , my beloved KRAS, the overexpression in the shot and @VikiLovesFACS and why she will never ever talk about miRswitches with you and ignores the genexpression: