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More from @NarfGb

Mar 28


LOOL! @Jikkyleaks @Fynnderella1 @KathMLee1 @ARadlerPohlDr

You're spreading uhm "Fake news" follow @drbeen_medical the clowns immagination.

Wait? Wasn't he the one also discussed the 1st paper of IgG4 and concluded no reason to worry?:
Read 6 tweets
Mar 27
How do you explain Mitogen Activated Protein kinase in layman's terms? How do you explain that you can guarantee that cell is done when you play with this cascade? How do you explain the crosstalks with the lysosome-regulating mTOR complex (mTORC(1/2) or the interactions with AKT
(serine/theronine kinases), for example, and get across what is fact in a layman-friendly way? "That's a 6 for cancer lottery and now just let it surprise you when and where because we can't unravel the biodistribution for you in more detail?"
I am open to suggestions and ideas!

[I think this question is mainly addressed to all those who should know so much more than I do:
Read 7 tweets
Mar 27
Side note:

The basic principle of all the crosstalks is actually absolutely simple to understand:

If a signal is sent out when it should not be active, the entire pathway is banged through and all the crosstalks are confused.

link.springer.com/article/10.100…
Diabetes

mdpi.com/2076-393X/10/1…

bmcendocrdisord.biomedcentral.com/articles/10.11…

Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity

ncbi.nlm.nih.gov/pmc/articles/P…
emjreviews.com/diabetes/artic…

springermedizin.de/inactivation-o…

embopress.org/doi/full/10.10…

sciencedirect.com/science/articl…

The Activation of ERK1/2 and JNK MAPK Signaling by Insulin/IGF-1 Is Responsible for the Development of Colon Cancer with Type 2 Diabetes Mellitus

journals.plos.org/plosone/articl…
Read 5 tweets
Mar 26
1/

I was asked if I cean break it down so even 12 years old can get it... Trying my best also I am not really good in such things. @ClareCraigPath
@ClareCraigPath 2/

Imagine: You want to sell a patent based on LNP technology. Would you then ignore your previous research that dealt with micro RNAs in cancer? Would you keep quiet that you knew very well that these micro RNAs would be affected after the transfection shots and lie about it?
@ClareCraigPath 3/

After all, your patent depends on the success of these shots. Would you lie about how the LNPs are distributed?

This is exactly what Viki Male did by deliberately concealing her dad's work and his patent.
Read 4 tweets
Mar 25
1/3

pubmed.ncbi.nlm.nih.gov/26028026/

ncbi.nlm.nih.gov/pmc/articles/P…

Funfact: and another nice reminder. I liked the graphic @drkohilathas used here to make the point why you don't screw with crosstalks without thinking it through the end.

ImageImage
2/3



I really pray that Rapamycin will work. It could be a powerfull tool in the fight of that what we expect to see the coming years. As you can see in the tweet of @drkohilathas: If you have a drug that works it has multiple positive effects on diverse
crosstalks and won't dysregulate the nat. way of the crosstalks in screwing for example the e2f, cdk2 / 4/6 uncontrolled and trigger absolut spontanous events.

Read 4 tweets
Mar 24
1/

Let's break another cheese with the mouse @Jikkyleaks , my beloved KRAS, the overexpression in the shot and @VikiLovesFACS and why she will never ever talk about miRswitches with you and ignores the genexpression:

genervter.substack.com/p/warum-erwart…

crimsonpublishers.com/aics/fulltext/…
3/

Do you remember when we told you you don't mess with the TLR and get a propper NF-kB reaction?

nature.com/articles/s4154…

pnas.org/doi/10.1073/pn… (4)
Read 15 tweets

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