Thread by @drkohilathas

Colostrum

The first milk that mammals produce after giving birth with anti-inflammatory, immunomodulatory, antiviral, gut healing, neuroprotective, anti-cancer, immune-boosting post-exercise, anti-spike protein, and free iron chelating properties.

A THREAD 🧵

Colostrum is the first milk that mammals produce after giving birth; it has been known for centuries for its health benefits and has a very different composition from milk produced later in lactation.

ncbi.nlm.nih.gov/pmc/articles/P…

This milky fluid has evolved to optimise the care for mammalian neonates and is composed of various bioactive components that contribute significantly to the initial immunological defence in the baby as well as to the growth, development, maturation of the neonatal GI tract.

Research has shown that the bioactive components in bovine colostrum from cows are 100- to 1000-fold more concentrated than those in human colostrum; humans are also able to digest bovine colostrum; thus, it is emerging as a food supplement.

ncbi.nlm.nih.gov/pmc/articles/P…

Colostrum is rich in bioactive components such as immunoglobulins, lactoferrin, lactoperoxidase, oligosaccharides, vitamins, and various growth factors.

The available evidence suggests that bovine colostrum supplementation may reduce microbial translocation across the gut mucosa; may suppress gut inflammation and thus a possible treatment aid in those with inflammatory bowel disease; helps maintain gut barriers;....

....may improve overall immunological function (for e.g. increasing NK cell function); may improve post-exercise recovery as well as attenuate exercise-related immunosuppression;....

pubmed.ncbi.nlm.nih.gov/24571383/

...may help to reverse short-term memory lapses caused by neuronal cell death as well as attenuate the damage done by prions, just to name a few benefits.

ncbi.nlm.nih.gov/pmc/articles/P…

Lactoferrin, a glycoprotein found highly in colostrum, exerts antibacterial as well as antiviral, anti-inflammatory, immune-modulatory, neuroprotective, and anticarcinogenic effects.

ncbi.nlm.nih.gov/pmc/articles/P…

These activities are thought to be largely down to lactoferrin’s capacity to bind to iron. However, the potential molecular mechanisms by which lactoferrin exerts its multiple effects are still under investigation.

ncbi.nlm.nih.gov/pmc/articles/P…

The other well studied component of colostrum is transforming growth factor beta (TGF-β), a cytokine with immunomodulatory and anti-inflammatory functions that has not only shown to balance and maintaining intestinal immunity....

tandfonline.com/doi/full/10.10…

but also control or inhibit airway inflammation and the hyper-reactivity caused by effector Th2 cells.

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In one study of two hundred patients with COVID-19, the use of colostrum significantly reduced recovery time.

pesquisa.bvsalud.org/global-literat…

Another study showed that bovine colostrum-derived antibodies blocked the spike protein and ACE2 interaction in different in vitro assays.

journals.plos.org/plosone/articl…

The use of lactoferrin in COVID-19 patients reduced the time it took to get a negative test.

ncbi.nlm.nih.gov/pmc/articles/P…

Lactoferrin has also been shown to protect host cells from virus attachment as well as attaching to SARS-CoV-2 and the spike protein in particular.

frontiersin.org/articles/10.33…

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Most studies have been conducted in healthy adults using doses that range from 14 mg taken three times per day to 60 g daily. Some benefits are usually noticed after long-term use (>2 months).

It is recommended that colostrum be produced organically and be free of adulterants like pesticides, herbicides, anabolic hormones, antibiotics, and other chemicals. It should also not be processed at high temperatures and pressures.

pubmed.ncbi.nlm.nih.gov/25781716/

Different breeds of cow, milking times, and various formulations change the composition of colostrum.