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Billy Bostickson 🏴👁&👁 🆓 Profile picture
@BillyBostickson
Apr 1, 2023 • 15 tweets • 6 min read • Read on X
1. Alternatives to Gain of Function Research
Loss of Function Research
Molecular dynamical modeling of viral proteins
Interactions with inhibitors and receptor
In vitro studies of specific properties required for human adaptation using single proteins
archive.ph/Lzwxz
2. More Alternatives

In vitro studies of genetic interactions between loci in viral proteins using replication-incompetent viruses – epistatic interactions

Sequence database comparisons of genetic properties of human and animal adapted viruses

thebulletin.org/2022/06/gain-o…
3. Ethical Alternatives

"to Experiments with Novel Potential Pandemic Pathogens"

journals.plos.org/plosmedicine/a…
4. The Seven Deadly Sins of....

Biomedical Research

by Laura H. Kahn

gjia.georgetown.edu/2023/03/03/the…Image
5. The latest egregious example in a long list

6. Now is the time to support @BiosafetyNow



@BioSRP
@pricklyresearch
@R_H_Ebright
@mattwridley
@gdemaneuf
@WashburneAlex
@Ayjchan
@alisonannyoung
@BillyBostickson
@nicholsonbaker8
@Bryce_Nickels
@tony_vandongen
@angoffinet
@BiophysicsFL
@ColinDavdButler biosafetynow.orgImage
7. What Needs To Be Made Public

All proposals & progress reports discussing dangerous virus experiments & documents related to the planning of the experiments

Details as to when, where & why such experiments were planned including any review processes involved

Risks & Benefits Image
8. Question of Biowarfare Research

It is now clear (to me) that the US, despite its denials, has pursued an illegal biowarfare program, by outsourcing collection of deadly viruses around the world & making them more virulent & pathogenetic.

We now have all the evidence we need
9. Public Denials, Ongoing Research.

Of course, The US Government and the Scientists involved will never state that they are engaged in biowarfare research, but rather "biodefense" and the noble drive to develop vaccines and prophylactics for deadly viruses & bacterial diseases. Image
10. The New Mantra: "Protecting the War Fighter"

Bio-Defense Now:

56 Suggestions for Immediate Improvements Final Report 85% Biological Defense Project (2005)

US Air Force Counterproliferation Center

airuniversity.af.edu/Portals/10/CSD…Image
11. Recently Highlighted in the #DEFUSE Documents

US Defense Advanced Research Projects Agency (DARPA) program to protect the US “warfighter”
by reverse engineering dangerous SARS-like bat viruses and creating aerosol vaccine sprays for use in bat caves

drasticresearch.org/2021/09/20/158…Image
12. No Need for Resurrection

of more controversial elements of US cold war biowarfare projects (well documented), e.g. aerosolisation of pathogens & their respective delivery programs, as they know exactly how to do all this

Now there is a wider repertoire of offensive weapons Image
Image
13. Extent of Pentagon Biowarfare Program?

Pentagon linked researchers like Lipkin (Mailman) Nichol (Atlanta) Baric (UNC) Bavari, Totura (USAMRIID), Denison, Munster (Rocky Mountain) & DARPA, DTRA, PREDICT Scientists involved could tell us a great deal!

14. Final Point in This Thread

We cannot only point the finger of blame at the US

Russia has continued Soviet work on biological weapons, but I will discuss that in a new thread



Did the Russian program encourage the Pentagon to covertly pursue its own?thebulletin.org/2022/10/the-ru…
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More from @BillyBostickson

Billy Bostickson 🏴👁&👁 🆓 Profile picture
May 9
“We are not a Cult”

DRASTIC and the investigative network that broke the Corona laboratory taboo

Must Read Interview!

The hard working "Two Ronnies" of DRASTIC

@gdemaneuf & @BillyBostickson

Interviewed by @franzbecchi for @berlinerzeitung

berliner-zeitung.de/politik-gesell…
1. Who are the “pandemic detectives”?

We speak with 2 of DRASTIC's prominent members:

@gdemaneuf (a data scientist & engineer)

and @BillyBostickson, longtime activist who was formerly part of opposition networks in China & HK & who operates anonymously for security reasons.
@gdemaneuf 2. My Responses

How did DRASTIC come about?

I started in January 2020, triggered by an article by Dan Sirotkin on the origins of the virus.

I connected with people like @R_H_Ebright & others on Twitter.

In May 2020, I chose the name "DRASTIC" for this decentralized group.
Read 18 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
May 8
22. Biased Sampling distorts Geography!

They use a dataset skewed toward Yunnan & Laos (p. 16), leading to phylogeographic models that place SARS-CoV ancestors far from Wuhan & Guangdong (p. 12).

This sampling bias undermines the reliability of their geographic inferences.
23. Neglecting Alternative Hypotheses

No SARS-CoV-like viruses near emergence sites?

They completely overlook non-bat reservoirs, like civets or pangolins, which could explain local circulation (p. 15).

This omission weakens their claim of distant ancestor origins (p. 12).
24. Inconsistent Molecular Clock Rates

The paper misuses variable NRR-specific clock rates, which give inconsistent SARS-CoV ancestor dates (e.g., 1944–2014 for SARS-CoV-2, p. 9).

Without any validation of bat-specific rates, this approach has no rational grounding (p. 14).
Read 33 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
May 8
5. Why did they resort to using the POW model?

To show that :

"our inferences of the time of the ancestors of human SARS-CoVs and their closest bat sarbecoviruses are UNBIASED"
6. Captain Obvious Strikes Again (1)

"we show that the ancestors of SARS-CoV-1 & SARS-CoV-2 likely circulated in horseshoe bat populations 100s to 1000s km away from the sites of the emergence of these viruses in humans & as recently as one to six years prior to this emergence"
7. Captain Obvious Strikes Again (2)

"Our findings indicate that there would not have been sufficient time for the direct bat virus ancestor to reach the locations of emergence of the human SARS-CoVs via normal dispersal through bat populations alone"
Read 12 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
May 8
1. Last sick joke of the Zoonati?

Fragments of human SARS-CoVs share recent common ancestors with bat viruses

SARS-CoV-like viruses have circulated in Asia for millennia

Ancestors of human SARS-CoVs likely circulated in China & Laos

Ancestors traveled unexpectedly fast
2. No Pangolins allowed!

There is insufficient temporal signal when calibrating a molecular clock using tip dating with sarbecoviruses sampled from bats & pangolins, likely as a consequence of limited sampling across space & time.

Therefore, we used SARS-CoV-1 genomes!
3. Definitely no pangolins!

As sampling locations of SARS-CoV-1, 2 & pangolin sarbecoviruses likely do not represent where their direct bat virus ancestors circulated, we EXCLUDED their locations from phylogeographic analyses to avoid the IMPACT of dispersal of non-bat hosts!
Read 24 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
May 4
1⃣ Virological 🦠 Whistleblower 😮‍💨?

"I worked with researchers in this space - virology + combatting future pandemics - in the decade before the pandemic".
2⃣ One Fact

"The one fact that the last 5 years never readily disclosed is that the core ideology of this community of researchers was fundamentally divided"
3⃣ Lab based creation of super-viruses

"About half of the researchers, including many leading virologists whose names appeared in the news, believed and argued passionately for the lab-based creation of super-viruses and super-bacteria"
Read 12 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Apr 23
1. The Second Lab Leak

Turning and turning in the petri dish,
The scientists cannot hear the warnings;
Genes recombine; the barriers cannot hold,
Evil virology is loosed upon the world,
The blood-dimmed tide is loosed, and everywhere
The ceremony of innocence is drowned;
2. The Second Lab Leak

The best lack critical thinking, while the professors
Are full of furious bias.
Surely some revelation is at hand;
Surely the cover up is now banned?
Lab Leak! Hardly are those words out
When a vast image out of Human Folly
Troubles my sight:
3. Somewhere in Wuhan

somewhere in the cell lines of a Chinese laboratory
A shape with pangolin body and the head of a bat,
A gaze blank and pitiless as the sun,
Is moving its long tongue, while all about it
Reel shadows of the indignant molested bats.
Read 6 tweets

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