BowTiedBiotech 🧪🔬🧬 Profile picture
Apr 2, 2023 10 tweets 5 min read Read on X
1/ The future of #CANCER THERAPEUTICS is looking brighter than ever with innovative treatments like CAR-T, which involves engineering a patient's immune cells to target and destroy cancer.

A thread highlighting the emerging therapeutic platforms we are most excited about 👇
2/ Another exciting development is the use of IMMUNE CHECKPOINTS, which can help boost the immune response against cancer by blocking proteins that prevent the immune system from attacking cancer cells.
3/ CD3 BI-FUNCTIONAL ANTIBODIES are also a promising area of research, these drugs can target both cancer cells and T-cells, which can help enhance the immune response against cancer.
4/ ADCs, or antibody-drug conjugates, are another exciting area of cancer therapeutics, which involves using antibodies to deliver targeted chemotherapy drugs directly to cancer cells.
5/ Synthetic lethality and DNA Damage Response (DDR), are also important areas of cancer research, as they involve targeting the underlying mechanisms that allow cancer cells to survive and grow.
6/ OFF THE SHELF CAR-T and TCR-T treatments, both ex-vivo and in-vivo, are also showing promise, as they involve engineering T-cells to recognize and attack cancer cells by targeting specific proteins on the surface of cancer cells.
7/ Degraders are another innovative approach to cancer therapy, which involves using small molecules to target and degrade specific proteins that are essential for cancer cell survival.
8/ Cancer vaccines are also a promising area of research, as they involve training the immune system to recognize and attack cancer cells, much like a traditional vaccine trains the immune system to recognize and attack a virus.
9/ Myeloid checkpoints are also an exciting area of cancer research, as they involve targeting specific immune cells in the tumor microenvironment that can promote cancer growth and survival.
10/ By combining these approaches and developing new ones, we may one day be able to effectively cure many types of cancer and improve the lives of millions of people around the world. #CancerTherapeutics #InnovativeTreatments #FutureOfCancerTreatment

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More from @BowTiedBiotech

Dec 2, 2023
1/ 🧠💻AI in Biopharma
Case Study: Roche

We will get more into this in the coming weeks in a Sunday newsletter. Sunday's are where we discuss topics related to emerging biopharma strategy.

But follow this thread for some super cool real life use cases from Roche 🧵👇
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2/ This use case caught our eye- using AI to develop clinical biomarkers for development.

That is an excellent idea! Have not seen much of this in action.

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3/ Now for the fun stuff - R&D!
We remain skeptical, but cannot lie there are some really cool things happening at Roche AI in R&D

4 Use Cases

1. Indication adjacency analysis
2. Growth conditions for screens
3. Bi/multi-fx targeting suggestions
4. Tox prediction Image
Read 12 tweets

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