Thread by @drkohilathas

Fisetin

A bioactive flavonoid anti-inflammation, anti-oxidative, anti-aging, anti-allergic, immunomodulation, cardioprotection, neuroprotection, anti-cancer, and importantly anti-senescence properties.

A THREAD 🧵

Fisetin is a bioactive flavonoid found in small concentrations in fruits and vegetables such as strawberry, apple, persimmon, grape, onion, and cucumber.

In one study, the highest concentration of fisetin was found in strawberries (160 mcg/g), followed by apples (26.9 mcg/g), and persimmons (10.5 mcg/g).

pubmed.ncbi.nlm.nih.gov/9782673/

Flavonoids in general are known to have a range of positive biological effects, mainly due to their ability to scavenge free radicals.

ncbi.nlm.nih.gov/pmc/articles/P…

Their regular consumption is associated with a reduced risk of a number of chronic diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.

pubmed.ncbi.nlm.nih.gov/25272572/

Feinstein has been shown to inhibit oxidation, activate antioxidant defences, inhibit the growth of various types of cancer, inhibit MMP activity (similar to Chaga)....

pubmed.ncbi.nlm.nih.gov/22524676/

Matrix metalloproteinases (MMPs) have a dual role in tumour growth and metastasis processes. They promote tumour growth by degrading matrix barriers and by enhancing blood vessel growth.

ncbi.nlm.nih.gov/pmc/articles/P…

Feinstein has also shown to inhibit mast cell activation, act as a neuroprotective agent, reduce the impact of age and disease-related brain function, as well as have immunomodulatory effects.

ncbi.nlm.nih.gov/pmc/articles/P…

Fisetin has also shown great cardiovascular protective potential. One study showed that fisetin protected against cardiac cell death, and another showed it stopped cardiac hypertrophy in mice.

nature.com/articles/s4159…

Senolytics are a class of drugs that selectively clear senescent cells.

Senescent cells are cells that cannot divide or die and are associated with ageing and inflammation (as well as COVID-19).

More on senescent cells 👇🏾

twitter.com/search?q=%40dr…

Fisetin has has been the talk of the town after a 2018 study demonstrated that, when tested against a panel of other flavonoids, fisetin had the most potent senolytic activity in several cell types in vitro.

ncbi.nlm.nih.gov/pmc/articles/P…

And when given to mice, fisetin showed a significant reduction in the percentage of senescent cells. Most interestingly, the study also showed that fisetin reduced the fraction of senescent T and NK cells, in other words, revitalising the immune system.

ncbi.nlm.nih.gov/pmc/articles/P…

The authors of the study note that

“Chronic exposure to fisetin improves healthspan and extends the median and maximum lifespan of mice.”

ncbi.nlm.nih.gov/pmc/articles/P…

In another study comparing four flavonoids, only fisetin was shown to significantly help the induction of memory formation in certain areas of the brain.

pubmed.ncbi.nlm.nih.gov/29317180/

Fisetin was also shown in another study to be very effective at inducing nerve growth, giving results almost indistinguishable from those obtained with nerve growth factor.

pubmed.ncbi.nlm.nih.gov/15312169/

If you like my threads, then you may find if of interest to know that I source the information for it from my recently released book.

People are seeming to enjoy it!

Click on the link to find out more👇🏾

callingouttheshots.xyz

There have been no trials on the use of fisetin on humans as of yet, and thus no established recommended dosage.

Most fisetin supplements range from 100 to 500 mg a day. In clinical trials, the equivalent human daily doses of 100–1400 mg of fisetin were used.

nootropicsexpert.com/fisetin/#fiset…

The 2018 study gave mice 100 mg/kg of fisetin for 5 consecutive days, which comes out to be approximately 8 mg/kg in human adults.

ncbi.nlm.nih.gov/pmc/articles/P…

Imagine what combining this with other supplements I have mentioned, like rapamycin, and fasting could do?

https://twitter.com/drkohilathas/status/1639308125864968193