Harriette Van Spall, MD MPH Profile picture
Apr 4 4 tweets 9 min read Twitter logo Read on Twitter
💥#McMaster #CardiologyGrandRounds by @johneikelboom
🩸 People with #AF are inadequately anticoagulated, largely related to MD hesitancy
🩸#Bleeding risk prediction tools have modest performance
🩸Bleeding risk iproportional to stroke risk, net benefit favours #antocoagulation
2/
🩸Few reasons to withhold #OAC, even in frail, older adults
🩸Across spectrum of #bleeding risk in AF, #stroke risk is higher
🩸#DOACs preferred over warfarin in #nonvalvular #AF
3/
🩸Most #DOACs safe in #CKD, some require dose adjustment
🩸Dabigatran contraindicated in eGFR<30
🩸Limited RCT evidence in #Hemodialysis

#AtrialFibrillation #Anticoagulation
Treatment of #LVThrombus
🩸#DOACs a reasonable option vs #warfarin
🩸#OAC duration depends on context & persistence of protruding LV thrombus
🩸Persistent laminar thrombus doesnt require longterm anticoagulation
🩸No evidence to support #OAC in primary prev of LV thrombus
4/

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More from @hvanspall

Feb 26, 2019
Proud to have led this #clusterRCT, presented @ESCCardio's #LBCT session & published today in @JAMA_current. Among 2495 adults (50% women) hospitalized for #HF, a transitional care model implemented in our publiclyfunded system did not ⬇️time to comp readmission/ED visit/death.
There was a significant improvement in the patient-reported outcomes of #discharge-preparedness, #qualityofcaretransition, and #QOL. However, there was no improvement in #QALY. The #PROs were not adjusted for multiplicity, but we will do post-hoc exploratory analysis.
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