Thread by @drkohilathas

Green tea epigallocatechin-3-gallate

The tea flavonoid with anti-inflammatory, antioxidant, cardioprotective, neuroprotection, and anti-prion properties.

A THREAD 🧵

Tea comes from the leaves of Camellia sinensis and is primarily produced in four varieties, i.e., white, green, oolong, and black, depending on the oxidation and fermentation technique applied.

fao.org/3/i4480e/i4480…

Out of all tea produced, only 20% is green tea. Green tea is made from unfermented leaves and reportedly contains the highest concentration of powerful flavonoids. The main flavonoid in green tea is called catechins, which make up 30–40% of the solid components of the tea.

And out of the various catechins in green tea, epigallocatechin-3-gallate (EGCG) is the most abundant.

It is thought that the various beneficial effects of green tea, including anti-inflammatory, anti-carcinogenic, antimicrobial, and anti-oxidative effects, are mainly due to EGCG.

pubmed.ncbi.nlm.nih.gov/27338088

In vitro and in vivo studies have shown the ability of EGCG to counteract various cancer cells via down regulating the MMPs and induce cancer cell death by inactivating NF-κB.

ncbi.nlm.nih.gov/pmc/articles/P…

More on NF-κB.

https://twitter.com/drkohilathas/status/1633104859938299905

https://twitter.com/drkohilathas/status/1642501414210490372

With regards to metabolic and cardiovascular health, EGCG has been shown to exhibit a wide range of therapeutic properties, including anti-atherosclerosis, anti-cardiac hypertrophy, anti-myocardial infarction, and anti-diabetic effects.

pubmed.ncbi.nlm.nih.gov/28864169/

Interestingly, in one study of twenty-five male patients with wild-type transthyretin amyloid cardiomyopathy, a disease primarily affecting the heart caused by accumulation of a protein called transthyretin...

12 months of daily consumption of 1,200 mg green tea extract containing 600 mg EGCG was shown to reduce the pathological growth of part of the heart.

ncbi.nlm.nih.gov/pmc/articles/P…

ECGC has also been shown to inhibit the aggregation of other proteins in the brain that are linked to various disease states.

frontiersin.org/articles/10.33…

ECGC seems to have preventative effects on prion disease too, in part due to autophagic pathways. EGCG is known to promote autophagy.

pubmed.ncbi.nlm.nih.gov/25991666/

With regards to COVID-19, ECGC has shown in lab studies that it inhibits the interaction between the RBD of spike proteins and the ACE2 receptor.

cellandbioscience.biomedcentral.com/articles/10.11…

Before you scroll further, if you're interested in learning more about EGCG, over fifty other supplements, medicinal mushrooms and more, you can find it all in one place, the book!

Click on the link to find out more 👇🏾

callingouttheshots.xyz

There is currently no clear dosage recommendation for ECGC. A single cup of brewed green tea typically contains about 50–100 mg of EGCG.

ncbi.nlm.nih.gov/books/NBK29906…

One group of researchers suggested a safe intake level of 338 mg of EGCG per day when ingested in solid supplemental form.

sciencedirect.com/science/articl…

High levels (800 mg of EGCG or more) have been linked to liver damage.

efsa.onlinelibrary.wiley.com/doi/epdf/10.29…

EGCG may not be safe if you are pregnant and/or breastfeeding.

pubmed.ncbi.nlm.nih.gov/22641606/