2 of 5) We discuss LongCOVID classifications: Post Acute Covid: 3 to 12 weeks and Chronic Covid: symptoms beyond 12 weeks up to 3 years. We also discuss manifestations of the symptoms and risk factors and predictors.
3 of 5) We discuss vaccination and LongCOVID and the various pathologies including viral factors, bacteriophage-like actions of SARS-Cov-2, host factors, including autoimmunity, mast cell activation and down-stream impacts.
4 of 5) We discuss coagulation dysregulation including microclots and platelet hyperactivation.
5 of 5) We end with key outstanding questions including: How can we accelerate clinically
defined inclusion and exclusion criteria
for Long COVID studies?
How can we accelerate diagnosis and
clinical trials to test treatment
regimens? #Teamclots@Trends_Endo_Met
Here are our diagrams as can be seen in the paper.
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Practice points: MECFS
The evidence presented in this review resonates with the notion that ME/CFS is characterized by physiological pathology, and not psychosomatic illness. This is a biologically-driven disease characterized by vascular (including haematological) pathology.
Assessment of cardiovascular (specifically cardiac functioning) and haematological health are necessary steps in the clinical evaluation of ME/CFS patients.
Deconditioning does not seem to be responsible for the symptoms of ME/CFS.
Practice points
The evidence presented in this review resonates with the notion that ME/CFS is characterized by physiological pathology, and not psychosomatic illness. This is a biologically-driven disease characterized by vascular (including haematological) pathology.
Assessment of cardiovascular (specifically cardiac functioning) and haematological health are necessary steps in the clinical evaluation of ME/CFS patients.
Deconditioning does not seem to be responsible for the symptoms of ME/CFS.