Resia Pretorius Profile picture
Apr 19 6 tweets 3 min read Twitter logo Read on Twitter
1 of 5) Excited to share our new LongCOVID paper with co-authors @dbkell @PutrinoLab Asad Khan, Ashley Woodcock and Simone Turner. sciencedirect.com/science/articl…
2 of 5) We discuss LongCOVID classifications: Post Acute Covid: 3 to 12 weeks and Chronic Covid: symptoms beyond 12 weeks up to 3 years. We also discuss manifestations of the symptoms and risk factors and predictors.
3 of 5) We discuss vaccination and LongCOVID and the various pathologies including viral factors, bacteriophage-like actions of SARS-Cov-2, host factors, including autoimmunity, mast cell activation and down-stream impacts.
4 of 5) We discuss coagulation dysregulation including microclots and platelet hyperactivation.
5 of 5) We end with key outstanding questions including: How can we accelerate clinically
defined inclusion and exclusion criteria
for Long COVID studies?
How can we accelerate diagnosis and
clinical trials to test treatment
regimens? #Teamclots @Trends_Endo_Met
Here are our diagrams as can be seen in the paper. ImageImageImage

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More from @resiapretorius

Mar 23
Practice points: MECFS
The evidence presented in this review resonates with the notion that ME/CFS is characterized by physiological pathology, and not psychosomatic illness. This is a biologically-driven disease characterized by vascular (including haematological) pathology.
Assessment of cardiovascular (specifically cardiac functioning) and haematological health are necessary steps in the clinical evaluation of ME/CFS patients.
Deconditioning does not seem to be responsible for the symptoms of ME/CFS.
Read 10 tweets
Mar 23
We are excited to share our latest paper on ME/CFS, with my co-authors @dbkell and my PhD student, @massimo_nunes. @BloodReviews Cardiovascular and haematological pathology in myalgic encephalomyelit... sciencedirect.com/science/articl…
Practice points
The evidence presented in this review resonates with the notion that ME/CFS is characterized by physiological pathology, and not psychosomatic illness. This is a biologically-driven disease characterized by vascular (including haematological) pathology.
Assessment of cardiovascular (specifically cardiac functioning) and haematological health are necessary steps in the clinical evaluation of ME/CFS patients.
Deconditioning does not seem to be responsible for the symptoms of ME/CFS.
Read 10 tweets

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