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Paul Maidowski Profile picture
@_ppmv
Apr 19 • 24 tweets • 12 min read Twitter logo Read on Twitter
1. The real risk of #SARS Let'er R.I.P (Re-Infection Policy) is positive feedback on pathogens OTHER than SARS-CoV. Take #Mpox.

What is remarkable about this cluster in Taiwan, other than it not being in WHO statistics (Taiwan being no member state)? nidss.cdc.gov.tw/en/nndss/disea… Image
2. "Wear a mask and seek medical attention immediately"

WOULD you LOOK at THAT! Taiwan CDC recommends N95 for #Mpox! Almost like the virus is airborne*

* given respiratory symptoms and systemic disease, OF COURSE it is

based,
very science based scicomm health-epsh.ncku.edu.tw/p/406-1097-251… ImageImageImageImage
3. Taiwan reports 132 deaths, WHO only 120.

I'll share some literature next, when I find time; we volunteer ours after all.

Extending Let 'er R.I.P. (Reinfection Policy) from coronaviruses to poxviruses is quite the gamble.
cdc.gov.tw/TravelEpidemic…
worldhealthorg.shinyapps.io/mpx_global/ ImageImage
4. I'll cover all the bases.
5. Advanced epidemiological remarks by @RealCheckMarker. She says 'starter point' but that's really expert talk already:
@RealCheckMarker 6. As soon as 90 days after #Mpox infection, reinfection is possible. Even vaccinated individuals can be infected. Thus, WHO's warning is vital: states should include Mpox testing, vaxx and treatment in other health services such as for HIV and other STIs.
7. There's so much trash information out nowadays that can steal your health, or degrade society unethically. Pls focus.

@jmcrookston reminds us, always read the animal studies.

As system dynamicist or political scientist, I add, always read the patents.
8. SARS-CoV-2, a ssRNA virus, neatly packaged its 29 proteins into as few as 30,000 nucleotides.

Mpox (hMPXV), a linear DNA virus, encodes ~190 ORFs in its ~197,000 nucleotide genome.

Smallpox (variola virus, VARV) is the smallest of poxviruses (186 kb).
9. Some references in no particular order. "Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus" - the titles all sound the same lol link.springer.com/article/10.100…
10. Monkeypox virus: phylogenomics, host–pathogen interactome and mutational cascade microbiologyresearch.org/content/journa…
"Proteins E3 and CrmB revealed potential disruption of stability due to certain mutations. We identified a large number of mutations within the new outbreak clade. We need to move fast with the genomic analysis of newly detected strains for better prevention & treatment methods." Image
Mpox now follows SARS-CoV-2 to become a global challenge to humans. Said @LaurentAFKaiser poetically, Les cas de #variole dite du singe signent l’expansion d’un cousin de la variole originale que l’homme avait mis 200 ans à éliminer.

We have no 200 years. ImageImage
11. Evolutionary dissection of monkeypox virus: Positive Darwinian selection drives the adaptation of virus-host interaction proteins pubmed.ncbi.nlm.nih.gov/36710983/ ImageImage
12. HIV, SARS-CoV, MPXV: viral nucleic acid editing, a cellular defense mechanism mediated through protein families apolipoprotein-B mRNA-editing complex (APOBEC), ties these three viruses together. I'm not qualified to explain this stuff. very relevant.
sciencedirect.com/science/articl…
13. For such questions @RolandBakerIII is a good follow, keeping a keen eye on Mpox's next moves.
14. Airborne. - Or, more precisely, you can't exclude it being airborne. Hence N95 for patients and healthcare workers. onlinelibrary.wiley.com/doi/full/10.10… Image
15. Mpox drug overview onlinelibrary.wiley.com/doi/full/10.10…
16. Breakthrough infections journalofinfection.com/article/S0163-…
17. Monkeypox, a Literature Review: What Is New and Where Does This concerning Virus Come From? mdpi.com/1999-4915/14/9…
18. Overview sciencedirect.com/science/articl…
19. Genomic annotation and molecular evolution of monkeypoxvirus outbreak in 2022 onlinelibrary.wiley.com/doi/full/10.10…
20. Virulence differences of mpox (monkeypox) virus clades I, IIa, and IIb.1 in a small animal model

Clade IIb.1 may be evolving for diminished virulence or adapting to other species. pnas.org/doi/abs/10.107…
21. Animal host range of mpox virus onlinelibrary.wiley.com/doi/full/10.10…
22. Can Acanthamoeba Harbor Monkeypox Virus? - No thanks 🥴 mdpi.com/2076-2607/11/4… Image

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More from @_ppmv

Paul Maidowski Profile picture
Apr 21
1. Relevant SARS-CoV-2 pharmacological questions: Is Enovid as post-exposure prophylaxis (PeP) contraindicated in pregnancy? Asking for a friend 🤯 and the internet

It's an old OTC oral birth control drug, so you better be sure. thelancet.com/journals/lanse…
2. Taiwanese seem to love this TCM drug for SARS-CoV-2. No idea whether contraindicated, but something western MDs won't have heard of.

Pharmacological Mechanism of NRICM101 for COVID-19 Treatments by Combined Network Pharmacology and Pharmacodynamics mdpi.com/1422-0067/23/2…
3. Follow me for further fun investigations and scientific questions as we go deep on our favorite ongoing population wide eugenics experiment.
Read 5 tweets
Paul Maidowski Profile picture
Apr 20
Do we live in a society of science illiterates and noticed only as everyone had to put the cards on the table early 2020? More precisely, we see that @GhoshAmitav's Unthinkable applies to SARS-CoV as well as to climate.

CoV-2 was widely circulating in Italy by September 2019 (!) ImageImageImage
@GhoshAmitav 2. There is scientific debate what these findings mean if anything. Debate and implications are not reflected in public, politics, or even the wider scientific community. It's not our role to force such debate via twitter; our focus should be on solutions. academic.oup.com/cid/advance-ar…
3. For 1 Sep to 31 Dec 2019, Chang et al. 2023 found no SARS-CoV-2-specific antibodies in blood donors in Wuhan before Dec 2020, indicating no evidence of transmission of COVID-19 before December 2019 in Wuhan, China. Absence of e is no e of a, but still: academic.oup.com/proteincell/ar… Image
Read 6 tweets
Paul Maidowski Profile picture
Apr 20
I for one think it's incredibly funny for a giant flying dick to explode 30 seconds in,

right friends, can we pivot to ending SARS and climate breakdown now? We need all eyes on the balls, 😂😂
Could care less what happened at 30 seconds. How much CO2, $, materials, energy, but more important, management attention was withdrawn from solving real global problems - for this nonsense?
Building giant flying steel dicks is not the awesome performance you may think, tech bros. This is the shape of genuinely impressive problems you could work on solving, if you cared:
Read 7 tweets
Paul Maidowski Profile picture
Apr 20
1. Sharing research on long-run sequelae in SARS-CoV-1 survivors

18 years post infection (there were no reinfections in Cov-1!), 14 HCW in Tianjin: "Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational study" thelancet.com/journals/eclin…
2. Recovered SARS patients had a poor quality of life 12 years following recovery, susceptible to inflammation, tumors, glucose and lipid metabolic disorders.

For the 12-year study they recruited 25 SARS survivors; for the 18-years only 14, ironically due to COVID restrictions. ImageImageImageImage
2. "Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection" - Many good studies barely anyone read, and we shared them as volunteers on twitter like raw meat at a vegetarians' annual congress. nature.com/articles/s4159…
Read 4 tweets
Paul Maidowski Profile picture
Apr 20
Fantastic commentary. - It's been a running joke; by Jan 2020 we knew the virus likely walked into the Wuhan market on two legs before it walked out. The western obsession with this market is an ongoing scientific embarrassment.

@sciencecohen, Jan 26 2020 science.org/doi/full/10.11… ImageImage
@sciencecohen * It's been a walking joke since Jan 2020. Can't believe I let this slip! - Link zhuanlan.zhihu.com/p/104165093
@sciencecohen 2. I could add political scientist comments, if useful, but more important is the missing virological argument. @Harvard2H wrote the first peer-reviewed article alleging an origin in serial passage of SARS-CoV-2, explaining its peculiar genomic signature. onlinelibrary.wiley.com/doi/10.1002/bi… Image
Read 5 tweets
Paul Maidowski Profile picture
Apr 19
All who criticize Laura for linking an article: yes, right-wing outlets are literally the only backwater galaxies in the media universe talking about this! They ignore the virus over the vaccine.

If you don’t like it, start scientific policy analysis, to help us avoid the worst. Image
Thanks so much @LauraMiers. You (we all) shouldn’t need to do this 🙏
A few hundred scientific references, if you count studies quoted. (I share as much every day) - SARS-CoV-2 is fast becoming one of the best researched viruses, yet we’re still scratching the surface. The vaccines hold crucial scientific questions too.
Read 4 tweets

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