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Paul Maidowski Profile picture
@_ppmv
Apr 20, 2023 • 5 tweets • 3 min read • Read on X
1. Sharing research on long-run sequelae in SARS-CoV-1 survivors

18 years post infection (there were no reinfections in Cov-1!), 14 HCW in Tianjin: "Multiomic characterisation of the long-term sequelae of SARS survivors: a clinical observational study" thelancet.com/journals/eclin…
2. Recovered SARS patients had a poor quality of life 12 years following recovery, susceptible to inflammation, tumors, glucose and lipid metabolic disorders.

For the 12-year study they recruited 25 SARS survivors; for the 18-years only 14, ironically due to COVID restrictions.


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2. "Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection" - Many good studies barely anyone read, and we shared them as volunteers on twitter like raw meat at a vegetarians' annual congress. nature.com/articles/s4159…
3. 148 Chinese Han SARS survivors. This time from diverse Beijing hospitals but it's very close to Tianjin. (as I suppose everyone knows? ;)

Need much better data to research haplotype association with SARS-CoV-2 variants, and variant-specific sequelae. apjbg.com/ch/reader/crea…
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4. 15 year prospective cohort study in SARS survivors. In avascular necrosis of the femoral head, blood supply to the bone is interrupted. Please note part of the bone damage owed to misguided treatments, overuse of corticosteroids. I hear such medical errors are made even today.

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More from @_ppmv

Paul Maidowski Profile picture
Nov 19
1. May do SARS-CoV-2 science threads when I find time. "While association between ABO blood group and infection is well known for many years, lower susceptibility of O blood group to coronaviruses had already been reported nearly 20 years ago for SARS-CoV" degruyter.com/document/doi/1…
2. Transplacental SARS-CoV-2 protein Orf8 binds to complement C1q to trigger fetal inflammation - Yes, as we've been saying for years. Orf8 makes SARS (CoV-1/-2) unique among coronaviruses. Let's infect all the kids so we are really, really sure that's bad embopress.org/doi/full/10.10…Image
3. SARS-CoV-2 can trigger a devastating, destructive placental pathology causing placental dysfunction and fetal hypoxia, yet stillbirth is rare. The fetal hypoxia is acute/subacute, apparent as reduced fetal movements. 20% of participants in this study(!) sciencedirect.com/science/articl…Image
Read 8 tweets
Paul Maidowski Profile picture
Sep 20
1. The structural parallels of SARS-CoV-2 and HIV-1 were known already 20 years ago, from SARS-CoV-1. Yet COVID-19 policy and even most scientists ignore these parallels, failing to learn key lessons. Fundamentally, genetic recombination drives both pandemics—two typical articles

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2. Don't worry about the specific article—there are hundreds more, and more relevant ones. The lesson here is we face syndemics, overlapping epidemics that cluster with inequity, not just distinct pandemics. All reinforce each other
link.springer.com/article/10.118…
frontiersin.org/journals/micro…
3. Background. There are literally thousands such articles; no one integrates them. That's why as political scientist, for years already, I've been arguing that only institutionalization can help with such complexity. We need a @UNAIDS for SARS-CoV, sorry
Read 29 tweets
Paul Maidowski Profile picture
Aug 30
1. Growing bamboo is our best chance to avert climate breakdown: the plants build soil, help biodiversity, avoid GHG emissions, provide food & construction material, sequester carbon 30 times (!) faster than mixed temperate forest. Yet stunningly, no one coordinates this work yet 40 year old moso bamboo in southwestern France grown from seed. Photo Lihua Jiang, www.yunnan-bamboo.com
2. After 40 years of climate science - first AGGG, now IPCC -, everyone feels they know climate. Yet experts only really know their own field. Generalists and practitioners can implement solutions but need experts to develop them. Bamboo as climate solution is entirely unexplored
Two bamboo stands in Zhongshan Expo Park, Taipei
Bamboo species in Tapei botanical garden
3. Last time atmospheric carbon content was as high as today, 16 million years ago, Earth was >3°C warmer than today, the Arctic was ice free, and Iceland had a subtropical climate. People think they know what climate change means, but most really don't. mdpi.com/2673-4834/5/2/…
Read 47 tweets
Paul Maidowski Profile picture
Aug 21
We’ve shared this for years, it was known or suspected even before the pandemic from SARS-CoV-1. Friends of we’re going to learn at this rate, ignoring prepandemic science, populations worldwide will get into serious trouble
Background. Thanks for outstanding science communications @vipintukur
I'd like to delete my account, but then a sizable fraction of the early Covid twitter scicomm documentation - to show what was known when - would be gone. As far as I know, no one else with even a moderately sized account (>10k followers) shares the same readily available science
Read 5 tweets
Paul Maidowski Profile picture
Jun 13
“Bamboo is our best chance to slow climate breakdown. It can replace drivers of GHG emissions and biodiversity loss (food, construction, concrete, plastic), build soil & allow regrowing rainforest." - Let's test it. Grow bamboo as blueprint for a future ecological civilization 🧵
Moso bamboo (phyllostachys edulis) seedling grown from seed with tap root
Moso bamboo forest in China, stock photo
2. Giant bamboo dwarfs trees. As grass, it grows 30 times (!) faster and can be harvested every year. Timber takes decades; too slow. Stunningly, no one in the west described the unique climate mitigation potential of bamboo yet. - Note the rhizome system:

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3. Climate relevant will be the use in millions of ha of plantations, just like other economically important crops. After two months on this, some significant progress: air pot kindly donated 1 m of their professional U system, so I can test it for bamboo.
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Read 39 tweets
Paul Maidowski Profile picture
Jun 4
SARS-CoV-2 reminder: The more immune compromised the population, the less symptoms, the ‘milder’ it appears, the more severe it really is (=Long Covid, long term damage). That’s what even most scientists seem not to get
Thanks for vivid discussion everyone. It really is a fundamentally important point. Since I deleted most references for lack of structure (and frankly, just being fed up repeating the same points for 3 to 4 years), I'll look for new references that must have been published by now
Background
Read 8 tweets

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