1. You need to remind people that science is the process that takes us from confusion to understanding. In this sense science is the communication path man should be using to study how nature shapes us.
2. We have to remind ourselves that the path is fallible because of the process of nature and the nature of man. Man always creates errors and often he fails to understand why his methodologies can create many scientific fallacies believed to be fact. Much of what man has learned… twitter.com/i/web/status/1…
3. This occurs because Mother Nature’s hand is capable of erasing while she simultaneously write’s more wisdom that builds things around us. You begin to realize in every experiment and theory there’s no such thing as a complete lie or complete truth. There’s always some truth in… twitter.com/i/web/status/1…
4. Realizing what was once believed to be true, but no longer is true, is what creates man’s wisdom. Everyone starts out the same way in life. Shit at what they do. You learn, and you improve, and you make tiny little changes every day to become better than you were yesterday.
5. That’s how every scientist, physician, artist, writer, founder, lover, and designer built their careers and armamentarium. So when you look back at the work you did in this life, you can’t feel ashamed of your work. Celebrate your connection to it, because it proves your… twitter.com/i/web/status/1…
6. Be passionate about yourself and your life. It is you and you must own it. Enthusiasm can help you find the new doors, but it takes passion to open them. If you have a strong purpose in life, you don't have to be pushed. Your passion will drive you there. #Sunrise… twitter.com/i/web/status/1…
7. Many people arguing about diet, carbs or thyroid levels are missing the greatest points that biology is teaching us, because they do not realize the perspective of how our metabolisms have always been set, by circadian cycles and not much else. In fact, the… twitter.com/i/web/status/1…
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This picture below is analogous to the orientation of hydrogen atoms in water ice, hence the name “spin ice.” So might coherent domains in matrix water be capable of making a transient monopole using non-linear optics of light adjacent to a key protein? Could hydrogen… twitter.com/i/web/status/1…
WHAT MIGHT A MONOPOLE DO FOR CELLS? If the monopoles exist and can be controlled and manipulated like electric charges, then it would open a new era for the modern technology and biology. Why? It is predicted that its immediate impact would be on memory storage devices… twitter.com/i/web/status/1…
There is a quantum story here in between the words of these Tweets, and buried in the gif above, tied to Heaviside, Maxwell, DeBroglie, Onsager, and Feynman’s work: One of the big misconceptions about ocean waves is that we have the precept or belief that they’re generated by… twitter.com/i/web/status/1…
1. Cultured human skin cells keratinocytes & melanocytes, can produce and express POMC; POMC expression is enhanced by exposure to UVB, through a cyclic AMP-dependent pathway; & the action of UVB on POMC production involves a cellular response to oxidative stress.
2. It's been demonstrated in the literature that UVB radiation stimulates increased expression of the proopiomelanocortin gene. This is accompanied by production and release of alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropin (ACTH) by both normal and… twitter.com/i/web/status/1…
3. The production & release of both peptides are also stimulated by dibutyryl cyclic adenosine monophosphate (dbcAMP) & IL-1 alpha but not by endothelin-1 or tumor necrosis factor-alpha (TNF-alpha).
Light stress of the POMC system is a government idea to control the population using science they found in the 1960s when they used light stress to study gender variation. They are trying to use light to sculpt compliance to a coming economic reset. We are being preconditioned… twitter.com/i/web/status/1…
2. Consider that many human sex differences satisfy three conditions — they are culturally universal, are observable in newborns, and a similar pattern is seen in apes and other mammals. The largest sex differences found with striking cross-cultural similarity are in mate… twitter.com/i/web/status/1…
3. These gender patterns, which include more play fighting in males, are observable in other primates and mammal species, which, like humans, follow the logic of the theory of parental investment and have higher variance in male reproduction, and therefore more intense… twitter.com/i/web/status/1…
Sun is fired up for my current Patreon series on how she runs mammals.
2. Feeding behavior is under the control of central retinal pathway hypothalamic circuits. In this circuit, arcuate nucleus, activated agouti-related peptide expressing neurons promote food intake while POMC-producing neurons promote satiety.
3. Homeostatic feeding regulation can be disrupted by exogenous substances, such as cannabinoids. Activation of cannabinoid receptor 1 (CB1R) can lead to robust feeding despite animals being sated. This has big implications.
1. It is very rare these days to see children with untreated PKU but when I was a resident at Charity Hospital I got a chance to see several of them and it was always remarkable how those cases mimicked Parkinson's Disease and showed up rapidly in a child.
2. Kids with untreated PKU appeared normal in the first few months of life until it's noticed that they fail to achieve developmental milestones in time and their head circumference does not grow and their skin is pale and afflicted by breakouts.
3. The brain remains atrophic and mimics a lack of development that we see in neurodegeneration in older humans. Most untreated children come to medical attention after 6–9 months of life because of developmental delay, they have a musty body odor, microcephaly due to rapid…
With exposure to light, during rhodopsin photolysis, toxic retinoid side products (Vitamin A) can be produced in photoreceptor cells. Biogenesis of these products occurs when two molecules of all-trans-retinal condense with one molecule of phosphatidylethanolamine in the… twitter.com/i/web/status/1…
2. Evolution has developed a powerful mechanism that prevents the accumulation of retinoid side products in terminally differentiated photoreceptor cells. Throughout life, the debris of the photoreceptor outer segment (POS) apical part is phagocytized and digested by RPE cells… twitter.com/i/web/status/1…
3. However, the lysosomal enzyme system of the RPE cell is not effective in the degrading of POS debris, because the latter is supposed to contain modified retinoid side products of rhodopsin photolysis, as well as modified lipids and proteins. In other words, the lysosomal… twitter.com/i/web/status/1…