Thread by @ahandvanish

With the FDA public meeting for #LongCovid coming up tomorrow, it's a good time to think about: what kind of drugs *could* we trial for #LongCovid?

The possibilities are honestly endless! Here is a sampling (absolutely not inclusive):

1. JAK-STAT inhibitors (Barcitinib, Rituximab)

2. Anticoagulants/antiplatelets (including supplements like Nattokinase/serrapeptase & Pycnogenol, but also Sulexodie, Sildenafil, statins, and triple therapy protocols)

3. Antivirals for reactivation of latent viruses (Valcyte, Famvir, Valacyclovir, Artemisinin), also EBV vaccine when available

4. Intravenous immunoglobulin (IVIG), for many reasons but esp for those with Small Fiber Neuropathy

5. Antivirals against COVID (Remdesivir, Molnupiravir, Paxlovid)

6. Beta blockers (esp for those with POTS)

7. Ivabradine (incl for those with POTS)

8. Drugs that regulate brain's microglial cells, including Low Dose Naltrexone (LDN) & Low Dose Aripiprazole (LDA)

9. Prescription mast cell stabilizers (Ketotifen, Cromolyn sodium - the latter esp for gut symptoms)

10. Anti-CGRP medications (Emgality, Ajovy, Aimovig, Nurtec, Qulipta) (esp for those with migraines)

11. Therapies targeting dysfunctional glymphatic drainage

12. Mitochondrial therapies (Ubiquinone/Coenzyme Q10, Acetyl-L-Carnitine, maybe Oxaloacetate)

13. GI targets (Lactoferrin, drugs that improve gut permeability, specific probiotics esp non-histamine inducing ones & strains based in existing research; also cromolyn sodium from #9)

14. Mestinon (esp for Post-exertional malaise)

15. Modafinil (esp for nerve, cognition, & POTS)

16. Midodrine (esp for POTS)

17. Colchicine & Spironolactone

18. Peptides, esp for the subset with connective tissue issues/resulting craniocervical instabilities

19. Additional options: Maraviroc, Glutathione infusions, Perispinal etanercept, Alpha lipoic acid, DRP-1 Inhibitors, CPAP & BiPap machines for COVID-triggered obstructive sleep apnea, Cyclophosphamide, Inspiritol, Isoprinosine, Ampligen

These are options collected by researchers & patient advocates and are being formalized in a clean document to be released shortly, but I wanted to put them out & gather feedback and see what's missing from this list (or shouldn't be on here)?

Follow these folks who are heavily thinking about treatment options in #LongCovid! @PutrinoLab @exceedhergrasp1 @microbeminded2 @MichaelPelusoMD @Steve_Bellan @ales_frost @VirusesImmunity @polybioRF @BhupeshPrusty @resiapretorius @WesElyMD

(apologies, too many to list everyone!)

And if you want to submit a public comment to the FDA about what should be trialed, you can do so here: regulations.gov/document/FDA-2…