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kim: emusified and digested slowly Profile picture
@therustychemist
Apr 30 • 11 tweets • 4 min read Twitter logo Read on Twitter
SARS-CoV-2 contains a novel nuclearization sequence PRRARSV in the spike protein. This is equivalent to the Simian Immunodeficiency Virus SV 40 TAg. Both the spike protein itself and mRNA are found to translocate to the nucleus.
ncbi.nlm.nih.gov/pmc/articles/P…
Here is general information SV 40 TAg from Wikipedia. The protein is ideal for studying nuclearization signals.

en.wikipedia.org/wiki/SV40_larg…
The spike is imported into the nucleus with importin a.
sciencedirect.com/science/articl…
Cellular immortalization or sensesescence is pushing cells past their Hayflick limit of allowed cellular divisions before they undergo apoptosis. Immortalization is like cancer cells where they continue "living" past this limit.
ncbi.nlm.nih.gov/pmc/articles/P…
This will cause telomeres to become shorter. It is causing our genes to be chewed up. It does this by suppressing retinoblastoma pRb and p53, both tumor suppressing proteins.
I don't have full access below. The first phase "lifespan extension" cells proliferating for a limited number of cell divisions. The second phase is immortalization and occurs only in certain cells. Analysis indicates it's a gene inactivating event.
pubmed.ncbi.nlm.nih.gov/7711112/
Here are a few articles...
Embryonic fibroblasts under some conditions..
nature.com/articles/emm20…
If this is a temperature sensitive allele, the nucleic acids in the temperature sensitive region may be unstable.
sciencedirect.com/science/articl…
Our own DNA damage signaling proteins help it remain stable propagate. Inhibiting DNA damage repair and signaling proteins may help.

journals.plos.org/plospathogens/…
We can absolutely revert back to the Wild Type RBD of the spike protein.
ncbi.nlm.nih.gov/pmc/articles/P…
I strongly encourage you to follow WHO guidelines to protect yourself from this #Ariborne #Lymphocytopenia and #NDD causing virus by wearing n95 grade mask and eye glasses/goggles.

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More from @therustychemist

kim: emusified and digested slowly Profile picture
May 2
I think it's important that we get clarity and help for people with vaccine complications. I believe we should have more access to whether or not procedural and quality controls were assessed and followed. But I have a question about structure and mechanics.
The lipid nanoparticles in the article below are designed to go straight to the brain and target microglia.
pubs.acs.org/doi/10.1021/ac…
The Pfizer vaccine stabilizes the spike protein in the RBD up or closed position by making covalent proline bonds as they are only cleaved by certain serine proteases. This is so the spike protein cannot attack your CD4 cells, which are it's target.
nejm.org/doi/full/10.10…
Read 4 tweets
kim: emusified and digested slowly Profile picture
May 2
"The impact is due to the direct biological effects of HIV on the fecundity of infected women, as well as to its indirect effects upon behavior in the general population."
We should be angry. Implications here for SARS-CoV-2 early puberty and menopause in females (ref at end). We made huge strides in women's equality in the last 60 years. What does it mean for education if women need to start having children earlier because of earlier menopause?
SARS-CoV-2 has been shown to infect microglia. Indirect effects on behavior in the general population is due in part to infection of the microglial cells in the brain in areas like the hypothalamus and an influx of neutrophils and cytokines causing inflammatory destruction.
Read 13 tweets
kim: emusified and digested slowly Profile picture
May 1
There are significant differences in the male and female immune systems.
nature.com/articles/s4146…
What I notice most in relation to SARS-CoV-2, specifically, is that TLR4 and CD14 populations are higher in males. These are cells targeted by the virus. Also, the size and density in specific locations of microglia is different between the sexes.
Females are more likely to have autoimmune disease and Alzheimer's. "Those include genes involved in the complement system (Fcgr2b, Fcgr3A, Lrg1, Cfb, Prtn3, Xdh, Bst1, and C4a/C4b) and also in lipoprotein metabolism and the statin pathway (Apoe, Apoc2/Apoc4, and Pltp)."
Read 7 tweets

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