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๐จ๐ฟ๐ถ๐ฐ ๐ฎ๐ฐ๐ถ๐ฑ & ๐๐ผ๐๐
// THREAD //
๐จ๐ฟ๐ถ๐ฐ ๐ฎ๐ฐ๐ถ๐ฑ & ๐๐ผ๐๐
// THREAD //
๐ด Uric acid is a compound of Carbon- Nitrogen- Hydrogen- Oxygen, tht is a product of Metabolism (more later)
๐ด It is largely excreted through Urine & some of it is broken down by Gut Bacteria
๐ด It is commonly believed tht is a waste with no use.
Tht is absolutely NOT true
๐ด It is largely excreted through Urine & some of it is broken down by Gut Bacteria
๐ด It is commonly believed tht is a waste with no use.
Tht is absolutely NOT true
๐ด Uric Acid is biologically active.
๐ด Uric acid is an important antioxidant & also a marker of tissue injury tht acts as one of the regulators of our immune system.
๐ด It hs the highest concentration of any water soluble antioxidants found in our blood(50x powerful thn VitC)
๐ด Uric acid is an important antioxidant & also a marker of tissue injury tht acts as one of the regulators of our immune system.
๐ด It hs the highest concentration of any water soluble antioxidants found in our blood(50x powerful thn VitC)
๐ด When our body is under assault & confronted by an imbalance of free radicals & damaged cells, our body's antioxidant defences & our immune system swing into action in order to put things right.
๐ด High levels of uric acid are a warning sign that things are going wrong.
๐ด High levels of uric acid are a warning sign that things are going wrong.
๐ด When Uric acid levels get too high, it becomes unstable & can crystallize, especially in the joints. This results in local inflammation that causes a painful arthritis known as GOUT.
๐ด Most commonly seen in the big Toe on ur Foot. But it can hv an effect on all joints.
๐ด Most commonly seen in the big Toe on ur Foot. But it can hv an effect on all joints.
๐ด There r 2 reasons for excess Uric acid
1. Excess Uric acid Production (10% cases)
2. Under excretion (90% cases)
Or both
๐ด Uric acid is normally excreted by the kidneys into the urine & eliminated from the body.
But Insulin Resistance messes this up!
1. Excess Uric acid Production (10% cases)
2. Under excretion (90% cases)
Or both
๐ด Uric acid is normally excreted by the kidneys into the urine & eliminated from the body.
But Insulin Resistance messes this up!
๐ด This Causes Uric acid concentration to build up in blood.
๐ด There r 3 sources of Uric Acid
1. Purines
2. Fructose
3. Alcohol
๐ด Purines r organic molecules found in DNA and RNA. When cells r broken down & purines r processed, Uric acid is formed as a result.
๐ด There r 3 sources of Uric Acid
1. Purines
2. Fructose
3. Alcohol
๐ด Purines r organic molecules found in DNA and RNA. When cells r broken down & purines r processed, Uric acid is formed as a result.
๐ด Around 70% of the Purine r endogenous & rest r from diet.
๐ด Purines r mainly found in meat, some fish, organs etc.
๐ด Note tht exogenous purines r not much, compared to Endogenous.
๐ด More cell breakdown releases more purines & hence more uric acid is produced.
๐ด Purines r mainly found in meat, some fish, organs etc.
๐ด Note tht exogenous purines r not much, compared to Endogenous.
๐ด More cell breakdown releases more purines & hence more uric acid is produced.
๐ด Which is why Age effects Uric acid levels. So the reduced efficiency of excretion due to IR & other reasons.
๐ด Purines, especially from Diet is really a small player in this Uric acid game.
Cutting Meat is not the answer!
๐ด Purines, especially from Diet is really a small player in this Uric acid game.
Cutting Meat is not the answer!
๐ด Fructose or Fruit sugar is one of the simple sugar molecules (like glucose).
๐ด It's sweeter than Glucose.
๐ด Ur white sugar contains 50% Glucose & Fructose.
๐ด HFCS or High fructose corn syrup is a processed form of Fructose created from corn. It's Cheap & an industry Fav
๐ด It's sweeter than Glucose.
๐ด Ur white sugar contains 50% Glucose & Fructose.
๐ด HFCS or High fructose corn syrup is a processed form of Fructose created from corn. It's Cheap & an industry Fav
๐ด HFCS is 55% Fructose & 45% Glucose
๐ด Our ancestors used to consume very less fructose bcz Fruits, Honey etc were seasonal & very less in quantity (& less sweeter thn modern day selectively bread fruits).
๐ด Our ancestors used to consume very less fructose bcz Fruits, Honey etc were seasonal & very less in quantity (& less sweeter thn modern day selectively bread fruits).
๐ด Fructose & Glucose metabolism r totally different!
Glucose stimulates Insulin response from the pancreas, but fructose doesn't.
This doesn't make it SAFE
๐ด Like Alcohol, Fructose is directly metabolized by the Liver.
Glucose stimulates Insulin response from the pancreas, but fructose doesn't.
This doesn't make it SAFE
๐ด Like Alcohol, Fructose is directly metabolized by the Liver.
๐ด Within liver cells, the enzyme fructokinase begins its work, including the consumption of ATP (energy).
๐ด The end product of this process is Uric Acid.
๐ด Whts more problematic is tht Uric acid further activates Fructokinase & cascade of other things.
๐ด The end product of this process is Uric Acid.
๐ด Whts more problematic is tht Uric acid further activates Fructokinase & cascade of other things.
๐ด In evolutionary terms this mechanism is very useful in times of Food scarcity & perhaps human race wudnt hv survived if it wasn't for this.
๐ด However in modern day, Food scarcity is no longer a thing, but our body is tht of our ancestors. Tht mismatch causes all the problem.
๐ด However in modern day, Food scarcity is no longer a thing, but our body is tht of our ancestors. Tht mismatch causes all the problem.
๐ด Fructose has no direct effect on Insulin, but Uric acid, the product of Fructose metabolism causes Oxidative stress on Pancreatic Islets tht produce Insulin.
๐ด Alcohol metabolism is similar to tht of Fructose n causes similar problems.
๐ด Alcohol metabolism is similar to tht of Fructose n causes similar problems.
๐ด The issue with high Uric Acid isnt only GOUT
High BP, Fatty Liver, CKD, Obesity, Erectile dysfunction, T2D, Alzheimer's etc r all interconnected with elevated Uric acid (maybe not the cause)
High BP, Fatty Liver, CKD, Obesity, Erectile dysfunction, T2D, Alzheimer's etc r all interconnected with elevated Uric acid (maybe not the cause)
Solution....
Just take Allopurinol & suppress Uric Acid?
Hell No!
1. Limit Carbs, especially those with Fructose.
It helps in 2 ways. One it will cause less production of Uric Acid. Two it bring down Insulin resistance & hence improve its excretion through urine.
Just take Allopurinol & suppress Uric Acid?
Hell No!
1. Limit Carbs, especially those with Fructose.
It helps in 2 ways. One it will cause less production of Uric Acid. Two it bring down Insulin resistance & hence improve its excretion through urine.
2. Cut Alcohol
3. Fasting
4. Limit Organ meat if ur uric acid levels r too high.
5. Workout
3. Fasting
4. Limit Organ meat if ur uric acid levels r too high.
5. Workout
๐ด Supplements tht will Help
1. Quercetin
2. Luteolin
3. DHA
4. Vitamin C
5. Chlorella
1. Quercetin
2. Luteolin
3. DHA
4. Vitamin C
5. Chlorella
๐ด Get ur Uric Acid levels tested!
Keep it Under 5.5 mg/dL (don't take it upto 7 or higher)
*It's an inexpensive test.
Keep it Under 5.5 mg/dL (don't take it upto 7 or higher)
*It's an inexpensive test.
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