Thread by @ejustin46

KILLING ME SOFTLY ! 😰

Constant REINFECTION and exposure to newer variants SHORTEN LIFESPAN of a majority of the exposed population, by inducing major changes in their lymphocytes, what is called LYMPHOCYTOPENIA !

2) Lymphopenia (also called lymphocytopenia) is a disorder in which your blood doesn't have enough white blood cells called lymphocytes, which play a protective role in your immune system.

3) Reference : nature.com/articles/s4139…
Fig. Peripheral blood lymphocytes are infected by SARS-CoV-2 in COVID-19 patients.

4) Fig. SARS-CoV-2 in vitro infection of T cell lines or primary T cells

5) Fig. SARS-CoV-2 infection-induced apoptosis in T cells.

6) DISCUSSION
"Here, we showed that SARS-CoV-2 infected T lymphocytes, mainly CD4 + T cells, in an ACE2-independent manner. SARS-CoV-2 infection triggered pronounced T-cell death, which potentially contributed to lymphopenia in patients with COVID-19."

7) "T-cell infection may also pose profound influences on patients. Infected T lymphocytes not only lost the ability to control viral infection but may also carry viruses to other parts of the body through blood circulation."

Thanks for reading

8) FYI
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