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Paul Maidowski Profile picture
@_ppmv
May 16 • 9 tweets • 5 min read Twitter logo Read on Twitter
Someone explain like I’m five how SARS-CoV-2 differs from HIV-1 please
Someone explain like I’m five how SARS-CoV-2 does that
Someone #ELI5 how SARS-CoV differs from Ebola virus please. You see, you already infected all five year olds. These are legitimate questions. The only puzzle here is why not everyone is asking them. Image
Someone explain like I’m 5 how SARS-CoV differs from Dengue virus please. - While I’ll take coffee as cure, these are no rhetorical questions.
Review from March 2020 (!). Someone explain like I'm 5 why human interacting proteins overlap between SARS-CoV-2 and West Nile virus, Mycobacterium tuberculosis, HPV, Kaposi’s sarcoma-associated herpesvirus (KSHV), Chlamydia, Dengue, Ebola, HCV, HIV, Zika.
nature.com/articles/s4158… ImageImageImage
Someone explain like I'm 5 why scientists ignore 41 years of evidence-based medicine.

You're not doing anyone a favor; we're running out of time.
SARS-CoV-2 infects these cheerful little fellows too. Someone explain it to five year-olds that should happen in all of them, too:
This merits correction: Human coronaviruses (HCoV) can mirror retroviruses (HIV), but remain CoV's. They are more complex, with larger genome (30 kb vs 9.2 kb), faster evolution, and wider host range a greater governance challenge. We need precise analysis
This brilliant article on melatonin, LINE-1, nucleocapsid was hidden in other comments. Disappointingly, all infected friends so far ignored my advice to use melatonin early or couldn't get it. Wish I'd have had the reference.

Merci @DorissLoh @Matroned! mdpi.com/1422-0067/23/1…

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More from @_ppmv

Paul Maidowski Profile picture
May 16
1. To repeat, as this question affects billions and can be clarified: epidemiologists/public health, but sadly not climate scientists, address complexity since we lack binding legal climate instruments. I see no one but strangely me even try integrated analysis. That's not ideal.
2. Law requires previous scientific analysis. It's why I focused on science for YEARS even pre-pandemic. To what effect? No interest in the scientific community.

If your plan is, "Change everything everywhere worldwide within a few years", then I'm sorry to say you have no plan.
3. There will be TREMENDOUS policy resistance (a technical term) against any large-scale, sustained decarbonization.

If your plan is, "Everyone must comply with [plan X] and there must be no setbacks to stay within [budget Y]," then again, I'm sorry, you have no plan.
Read 4 tweets
Paul Maidowski Profile picture
May 16
1. Unsettling fact for climate scientists: Steve Bannon was CEO of Space Biosphere Ventures (#Biosphere2). Yes THE Movie producer, Breitbart, Trump-advisor guy. These folks have known all about and worked on climate change for over 30 years.

They are not stupid, on the contrary.
2. vice.com/en/article/qkj…
3. haha young Bannon Image
Read 6 tweets
Paul Maidowski Profile picture
May 16
Twitter search tells me I'm the first to share this clearly relevant article. My current theory is that 2020-2023 is a script idea for Black Mirror, rejected for imaginative yet low-fidelity writing 🤣
Here, too, I seem to be the first to share this? Strange. (The HIV scientists are also missing at least one SARS-CoV-2 coreceptor, ie the PCSK9 cleavage site. Folks I'm not even a virologist; if I notice such stuff, it's a sign things are not going well.) ImageImage
You all are welcome to support my patreon site - all espresso-support appreciated* - for doing your research for you.

*nearly a joke in itself, given the stakes we handle 👻☺️
Read 4 tweets
Paul Maidowski Profile picture
May 15
1. SARS/MERS-CoV and other ‘common cold’ human coronaviruses (HCoV) are neuroinvasive. Known for decades. Can cause long term neurocognitive disease.

This Intro by Dr. Talbot 2016 cites evidence from 2000, before even SARS-CoV-1: ImageImage
2. Research into the link from HCoV-OC43 infection before or during puberty to later onset of NDDs such as Alzheimer’s and Parkinson’s is ongoing. “Living with Covid” is adding billions of unwilling test subjects to the experiment. They deserve the truth.

3. SARS-CoV-2 is a unique coronavirus because it contains two furin-like proprotein convertases (PCs). A polybasic FCS (PC3) and a non-basic PCSK9 cleavage site, involved in cholesterol and fatty acid homeostasis.

PCs cleave glycoprotein, delivering viral genome to host cells. ImageImageImage
Read 6 tweets
Paul Maidowski Profile picture
May 14
50% case fatality ratio is little concern. Deadly diseases usually self-eradicate because people change their behavior, ie wear N95 masks. Real danger starts with a 'mild' acute phase, when the masks drop and people develop the insane idea to "live with Covid"/SARS-CoV/influenza.
It would take many months to develop vaccines.
H5N1 background,
Read 5 tweets
Paul Maidowski Profile picture
May 13
1. Ebola virus (EBOV) and SARS-CoV parallels. NOW you have my interest. mdpi.com/2077-0375/11/1…
2. @fitterhappierAJ mentioned Ebola as a better example for SARS-CoV-2 last year, but I just got it.

ORF8 Breaks Genetic System of Macrophage to Escape Reproductive Immunity by Telomerase and NOS-Like System chemrxiv.org/engage/chemrxi…
3. CD74是与主要组织相容性复合体Ⅱ(MHCⅡ)相关的跨膜糖蛋白,在免疫细胞中广泛表达,CD74标记约90%的低级B细胞淋巴瘤和20%的低级T细胞淋巴瘤。它的p41亚型可通过抑制组织蛋白酶介导的病毒蛋白质外壳裂解,对抗埃博拉病毒和新型冠状病毒,抑制埃博拉病毒和SARS-CoV-2进入宿主细胞 manu60.magtech.com.cn/biotech/articl…
Read 12 tweets

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