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Brad Profile picture
@Bradgolf1216
May 22 • 7 tweets • 3 min read Twitter logo Read on Twitter
So Endothelial dysfunction is the culprit for reduced oxygen perfusion to the tissues which in turn leads to dysfunctional aerobic metabolism and fatigue. Image
The Blood Brain Barrier consists of these Endothelial Cells and has been found breached in Covid Long haulers. ImageImage
What regulates the functions of the endothelium? Partly the GPCR receptors of course. Specifically the Sympathetic nervous system which is part of the ANS. Our small vessels are now narrowed due to the endothelium dysfunction. news-medical.net/whitepaper/201… ImageImage
So Autoantibodies against GPCR Receptors can explain endothelium dysfunction in one of two ways: 1) breaching the BBB and causing neuroinflammation in the brain specifically the hypothalamus and brainstem areas. This could theoretically alter endothelial dysfunction downstream.
2) Endothelial dysfunction locally. mdpi.com/2077-0383/10/1…
This is one more reason why covid longhaulers need BC 007 Immediately. I am curious to see how the endothelium functions after the infusion and how this affects energy levels and cerebral blood flow as well as the blood brain barrier function.
#LongCovid #pwME #Pots

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More from @Bradgolf1216

Brad Profile picture
May 24
GPCR Autoantibodies circulating the blood triggering neuroinflammation of the autonomic nervous system and small fiber nerves that control the body’s functions for daily living. Breaching Blood Brain Barrier and Gut Barriers to induce more neuroinflammation and dysfunction.
These same autoantibodies triggering microclots to form in some people. The autonomic dysfunction altered the baroreceptor reflex and now the body compensates by either altering blood pressure or heart rate in order to get blood back to the heart.
The dysfunction leads to narrowing of the small vessels and altered red blood cell shape which causes hypoxic conditions in tissues and without proper oxygen perfusion the body cannot maintain proper aerobic metabolism to make a majority of the body’s energy (ATP).
Read 21 tweets
Brad Profile picture
May 4
This is a thread for what is going on in long covid dysautonomia: Switch flipped in brainstem area, Immediate decrease in Cerebral Blood flow (CBF) upon being upright, Sympathetic system feels like it is constantly turned on and will not switch off 2)
Heart Rate increases slightly and diastolic blood pressure increases 15-30 points from laying down compared to standing, Others Heart Rate will increase significantly and blood pressure may not change. Blood flow is dysfunctional in the small vessels especially the capillaries.
Since blood is not flowing correctly this in turn will not allow oxygen to be perfused in the tissues correctly so this can create hypoxic conditions. These hypoxic conditions do several things but 2 specifically IMO: 1) Cause aerobic metabolism (krebs,ETC)to be dysfunctional.
Read 18 tweets
Brad Profile picture
Apr 24
ME/CFS is commonly developed after a virus/vaccine trigger. Is covid a virus? Yes 👍🏻. So that means a subset of the long covid patients will in turn be ME/CFS patients just by logic. 👨🏻‍⚕️Use your thinker and don’t be a stinker. 😏#LongCovid
See what they are doing here: ImageImage
🕵🏻‍♂️ ImageImage
Read 4 tweets
Brad Profile picture
Mar 3
Things we know about LC Dysautonomia so far: 1)Reduced Cerebral Blood Flow When Upright 2) Tachycardia and/or Blood Pressure Changes upon Standing. 3)Debilitating fatigue at certain times. 4) Non Cardiac Chest Pain 5) Alpha Synuclein deposits found in small fiber nerves for some.
6)GPCR Autoantibodies found by functional assays. 7) Spike protein identified in patient tissues at different time intervals. 8) Microclots found in long covid patients. 9)Breached Blood Brain Barrier has been identified by researchers. Dysfunctional Gut Barrier has been found.
10) Abnormal Cytokine levels in the brain that vary in different time intervals. 11) Profound Autonomic Dysfunction found in 67-75 percent of the patients. 12) Increased Intracranial pressure in some lc patients. 13) Patients have difficulty adjusting to stressful conditions.
Read 20 tweets
Brad Profile picture
Mar 3
For the record, I am not a bully or being mean to anyone. I respond with force when someone comes at me especially my character. I have people repeating semesters 2 and 3 times questioning my intelligence so pitiful. Sounds like a bunch of babies whining.
I love how some of them attack me and then play ignorant or victim (political tactic). I think it is all because I give a political opinion or two that is different than theirs unfortunately. Another good tactic is when you comeback they try to make you look unhinged.
That is exactly how low IQ people operate. So pitiful.
Read 4 tweets
Brad Profile picture
Mar 2
I think a blockedbybrad support group would be a great idea that way green face, professor chris, president john k (elle’s friend) and some of these other frauds so they can whine about politics and hate on white males in another forum and leave science to the smart peeps 😂
Counseling can be provided for the group that way when trump or desantis wins office in 2024 their psychological needs can be met.
Whoopsie, I will correct myself and say that I have never seen president John in any white male hate so my apologies. I appreciate the nice comments from him actually.
Read 5 tweets

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