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May 24 21 tweets 5 min read Twitter logo Read on Twitter
GPCR Autoantibodies circulating the blood triggering neuroinflammation of the autonomic nervous system and small fiber nerves that control the body’s functions for daily living. Breaching Blood Brain Barrier and Gut Barriers to induce more neuroinflammation and dysfunction.
These same autoantibodies triggering microclots to form in some people. The autonomic dysfunction altered the baroreceptor reflex and now the body compensates by either altering blood pressure or heart rate in order to get blood back to the heart.
The dysfunction leads to narrowing of the small vessels and altered red blood cell shape which causes hypoxic conditions in tissues and without proper oxygen perfusion the body cannot maintain proper aerobic metabolism to make a majority of the body’s energy (ATP).
The neuroinflammation on the cranial nerve of the ear from autoantibodies I predict can cause the tinnitus. Random anti inflammatory medications do almost nothing for this mechanism.
Blood vessels must now work harder to get blood back up to the heart and brain. This will lead to chronic venous insufficiency and bulging veins. This is due to the increased pressure in the veins.
The breached BBB now allows autoantibodies nearby to trigger inflammation in the brain. Notice the findings of the hypothalamus dysfunction and brainstem dysfunction/volume changes. These all function in part by GPCR receptors so the circulatory autoantibodies attack the ANS. Image
This neuroinflammation in the brain will alter blood flows on a continuous basis. You can hook a dysautonomia patient up to an ICU line and watch the blood continuously change up/down instead of being consistently supplied with blood like a healthy person.
Without healthy blood flows in the brain, this creates hypoxic conditions and brain fog/cognitive dysfunction sets in. Without the proper blood flow, hypometabolism sets in the brain which can be identified via a particular PET Scan used in certain laboratories.
Autonomic dysfunction also causes the brain’s neurotransmitters to be dysfunctional such as cortisol, dopamine, serotonin, etc. Sometimes they are high, low, in range but they are not always functioning correctly in dysautonomia patients.
Small fiber nerve damage/dysfunction alter the way our body responds to temperature and pressure changes. We can’t regulate our body temperature well in extreme weather environments and beware of barometric pressure changes as symptoms can flare. Image
The Autonomic Nervous System has a part called the Enteric Nervous System which controls the vast majority of GI functions from mouth to anus. It works closes with the GI reflexes including the gastrocolic reflex which is stimulated after eating.
This reflex is overactive after a large or high fat/spicy meal in most dysautonomia patients. Also the Migratory Motor Complex (MMC) in the GI system is dysfunctional. This complex is in charge of our GI motor patterns. This can be affected by autonomic dysfunction.
Since Fibromyalgia can accompany ME/CFS/POTS, I feel the study injecting the blood of a fibromyalgia patient into mice gives us important clues on how autonomic dysfunction may be working. pubmed.ncbi.nlm.nih.gov/34196305/
There is something in the blood of all of us (most likely autoantibodies gpcr and non-gpcr) that is triggering all of these symptoms. I believe BC 007 will improve/go into remission the symptoms caused by the autonomic dysfunction.
I believe there are other non-gpcr autoantibodies at play in some patients such as the ones causing small fiber neuropathy that need to be addressed. Maybe an aptamer can be developed that will inhibit those specifically.
BC 007 will most likely have to be given more than once such as after an infection or after a traumatic event because sometimes these autoantibodies will return after these events. Genetic predisposition to immunity dysregulation is from changes to the genes.
So since we can’t change the genes back, we must attack the mechanisms and drivers of the disease. GPCR autoantibodies are known drivers of many diseases including some peoples prediction of it driving dysautonomia in lc patients. Image
I would like for the BC 007 trial to test patients with 1) Trans cranial doppler test for cerebral blood flow 2) 10 min Poor man’s tilt table test (from laying down to standing) 3) 12-T MRI to check BBB, PET scan to check for Hypometabolism, CPET test.
They should bring in people that understand autonomics to help with the study if they haven’t already. BC 007 will be huge for the LC/Pots/ME/CFS communities and even potentially helping fibromyalgia and other chronic illnesses related to autoantibodies.
I am hoping we all can eventually get clinical access to functional assays to test for these GPCR Autoantibodies. Good Day Mate 👍🏻

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More from @Bradgolf1216

May 22
So Endothelial dysfunction is the culprit for reduced oxygen perfusion to the tissues which in turn leads to dysfunctional aerobic metabolism and fatigue. Image
The Blood Brain Barrier consists of these Endothelial Cells and has been found breached in Covid Long haulers. ImageImage
What regulates the functions of the endothelium? Partly the GPCR receptors of course. Specifically the Sympathetic nervous system which is part of the ANS. Our small vessels are now narrowed due to the endothelium dysfunction. news-medical.net/whitepaper/201… ImageImage
Read 7 tweets
May 4
This is a thread for what is going on in long covid dysautonomia: Switch flipped in brainstem area, Immediate decrease in Cerebral Blood flow (CBF) upon being upright, Sympathetic system feels like it is constantly turned on and will not switch off 2)
Heart Rate increases slightly and diastolic blood pressure increases 15-30 points from laying down compared to standing, Others Heart Rate will increase significantly and blood pressure may not change. Blood flow is dysfunctional in the small vessels especially the capillaries.
Since blood is not flowing correctly this in turn will not allow oxygen to be perfused in the tissues correctly so this can create hypoxic conditions. These hypoxic conditions do several things but 2 specifically IMO: 1) Cause aerobic metabolism (krebs,ETC)to be dysfunctional.
Read 18 tweets
Apr 24
ME/CFS is commonly developed after a virus/vaccine trigger. Is covid a virus? Yes 👍🏻. So that means a subset of the long covid patients will in turn be ME/CFS patients just by logic. 👨🏻‍⚕️Use your thinker and don’t be a stinker. 😏#LongCovid
See what they are doing here: ImageImage
🕵🏻‍♂️ ImageImage
Read 4 tweets
Mar 3
Things we know about LC Dysautonomia so far: 1)Reduced Cerebral Blood Flow When Upright 2) Tachycardia and/or Blood Pressure Changes upon Standing. 3)Debilitating fatigue at certain times. 4) Non Cardiac Chest Pain 5) Alpha Synuclein deposits found in small fiber nerves for some.
6)GPCR Autoantibodies found by functional assays. 7) Spike protein identified in patient tissues at different time intervals. 8) Microclots found in long covid patients. 9)Breached Blood Brain Barrier has been identified by researchers. Dysfunctional Gut Barrier has been found.
10) Abnormal Cytokine levels in the brain that vary in different time intervals. 11) Profound Autonomic Dysfunction found in 67-75 percent of the patients. 12) Increased Intracranial pressure in some lc patients. 13) Patients have difficulty adjusting to stressful conditions.
Read 20 tweets
Mar 3
For the record, I am not a bully or being mean to anyone. I respond with force when someone comes at me especially my character. I have people repeating semesters 2 and 3 times questioning my intelligence so pitiful. Sounds like a bunch of babies whining.
I love how some of them attack me and then play ignorant or victim (political tactic). I think it is all because I give a political opinion or two that is different than theirs unfortunately. Another good tactic is when you comeback they try to make you look unhinged.
That is exactly how low IQ people operate. So pitiful.
Read 4 tweets
Mar 2
I think a blockedbybrad support group would be a great idea that way green face, professor chris, president john k (elle’s friend) and some of these other frauds so they can whine about politics and hate on white males in another forum and leave science to the smart peeps 😂
Counseling can be provided for the group that way when trump or desantis wins office in 2024 their psychological needs can be met.
Whoopsie, I will correct myself and say that I have never seen president John in any white male hate so my apologies. I appreciate the nice comments from him actually.
Read 5 tweets

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