AIRBORNE transmission of respiratory VIRUSES
(in few graphs, layman terms)
"In contrast to droplets, aerosols can linger in air for hours and travel beyond 1 to 2 m from the infected individual who exhales them, causing new infections at both short and long ranges."
2) "Phases involved in the airborne transmission of virus-laden aerosols include (i) generation and exhalation; (ii) transport; and (iii) inhalation, deposition, and infection."
3) "The behavior and fate of virus-laden aerosols are inherently governed by their characteristic properties, including physical size, viral load, infectivity, other chemical components in the aerosol, electrostatic charge, pH, and the air-liquid interfacial properties"
3) "How long can aerosols linger in air?
For example, the time required for an aerosol of 100, 5, or 1 μm to fall to the ground (or surfaces) from a height of 1.5 m is 5 s, 33 min, or 12.2 hours, respectively."
4) "The movement of aerosols is more strongly influenced by airflow direction and pattern, type of ventilation, and air filtration and disinfection"
5) "Small aerosols tend to deposit in the tracheobronchial and alveolar regions on the basis of gravitational sedimentation and Brownian diffusion."
2) Astrocytes are the brain cells that can be infected and support the growth of the SARS-CoV-2 virus. This likely contributes to the neurological symptoms of COVID-19.
3) Experiments show ketamine, an anesthetic, can reduce astrocyte infection by earlier SARS-CoV-2 variants, but not newer variants. Ketamine does this by decreasing the virus's entry receptor and replication in astrocytes.
2) This first figure helps explain the first key mechanisms contributing to cognitive impairment in COVID-19 patients:
▶️ Direct viral entry and brain injury is shown in the first panel.
▶️ The role of hypoxia (lack of oxygen) in cognitive decline is depicted in the second panel
3) ▶️ The widespread systemic inflammation caused by COVID-19 is illustrated in the third panel.
For CHILDREN, the risk of LONG COVID after a SECOND INFECTION is 2.08 TIMES GREATER compared to the FIRST INFECTION. medrxiv.org/content/10.110…
2) Let's summarize first this study :
The researchers used medical records from 40 children's hospitals in the US between January 2022 and October 2023. They compared the risk of long-term issues in those with a second COVID-19 infection versus their first infection.
3) Results showed that children with a 2nd infection had a significantly higher risk of various long-term problems, including:
- Heart issues like inflammation and abnormal heart rhythms
- Changes in taste and smell
- Blood clots
- Kidney problems
- Fatigue and muscle/joint pain
What a "CLEVER" SARS-COV-2 virus !
... which induced a P812S mutation in a chronically ill individual, that is somewhat less pathogenic but enables the virus to infect a larger population. biorxiv.org/content/10.110…
2) This study looks at how a single mutation, called P812S, in the SARS-CoV-2 virus can have different effects. The P812S mutation was found in a person with a long-term COVID-19 infection.
3) The study found that the P812S mutation:
- Reduced the ability of the virus to enter cells and cause them to fuse together (form syncytia). This is linked to less severe COVID-19 disease.
- Helped the virus evade antibodies that target the fusion peptide region of the spike.
INSIDE a COVID-19 crashing WAVE (Nov. 2023 and Mar. 2024, coastal Kenya) 🌊
Fascinating information on variants, symptoms, reinfections, ...
Thanks @siamosolocani
for the study medrxiv.org/content/10.110…
2) The study examines the genomic and clinical epidemiology of a SARS-CoV-2 wave that occurred in coastal Kenya between November 2023 and March 2024. Key findings include:
- The wave was dominated by the XBB.2.3-like and JN.1-like Omicron subvariants ...
3) ... which were introduced through multiple independent events, primarily from North America and Europe.
- Genomic surveillance revealed at least 38 separate virus introduction events into the local population during this wave.
2) Here are the significant reductions in multiple key immune cell populations at 10 months after initial COVID-19 infection :
▶️ Total leukocyte (white blood cell) counts were reduced by 12%
▶️ Neutrophil counts were reduced by 11%
▶️ Monocyte counts were reduced by 10%
3) ▶️ Total lymphocyte counts were reduced by 14%
▶️ T cell counts were reduced, with CD4+ T cells down 16% and CD8+ T cells down 18%
▶️ B cell counts were reduced by 14%
▶️ Natural killer cell counts were reduced by 19%