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🧵 COVID TESTS
"Extreme differences in SARS-CoV-2 viral loads among respiratory specimen types during presumed pre-infectious and infectious periods"
"Throat-swab and saliva viral loads began to rise as many as 7 days earlier than nasal-swab viral loads in most individuals"
1/
"Extreme differences in SARS-CoV-2 viral loads among respiratory specimen types during presumed pre-infectious and infectious periods"
"Throat-swab and saliva viral loads began to rise as many as 7 days earlier than nasal-swab viral loads in most individuals"
1/
There is very low clinical sensitivity of nasal swabs during the first days of infection.
They found extreme differences among paired specimen types collected from a person at the same time point. 2/
They found extreme differences among paired specimen types collected from a person at the same time point. 2/
Omicron viral loads in three paired specimen types (saliva, anterior-nares swabs, and oropharyngeal swabs)
"Individuals often exhibited high, presumably infectious viral loads in oral specimen types when nasal viral loads remained low or even undetectable." 3/
"Individuals often exhibited high, presumably infectious viral loads in oral specimen types when nasal viral loads remained low or even undetectable." 3/
Combination nasal–throat swabs were inferred to have superior clinical sensitivity to detect infected and infectious individuals. 4/
" This demonstrates that single-specimen type reference standard tests for SARS-CoV-2, such as in clinical trials or diagnostics evaluations may miss infected and even infectious individuals."
academic.oup.com/pnasnexus/arti…
#COVIDTesting
academic.oup.com/pnasnexus/arti…
#COVIDTesting
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