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Post infection consequences of neurocognition
#longcovid on a global level has shown the consequences of LC and brought attention to post viral conditions
LC clinics benefit LC patients and MECFS patients as well. Pts can be at many different phases of the post viral conditions
A parent perspective on 17yo MECFS pt in Sweden- read about it online as this pt was followed. Will link after conference
Temporary resolved sampling of patients #remissionbiome - during the pandemic PTs were visited and transported to research facility in an international collaboration
Patients underwent metabolism is, surveys, clinical data and integration analysis - 3k samples being collected and analyzed
Again Lactate as an important marker of dysfunctional mito activity. Hypothesis: abnormal energy meta and abnormal hypoxia
The team took the lab on the road to western Sweden and set up the lab at a patient’s kitchen
Tests were performed on cognitive exertion, social exertion and low intensity physical exertion
Sampling of baseline, exertion, 5, 10 and 15 mins post exertion.
The ambulatory lab was able to collect samples despite challenges, like logging the bike (for low intensity exercise test) 15 flights w/o elevator
Patients were stratified by demographics and subject characteristics. Glucose and lactate were also monitored.
Over 2000 samples were collected and analyzed
Lactate was elevated vs healthy control from baseline to 30 mins post exertion
Samples are being analyzed metabolomics-life style related bio markers to try to map a phenotype (s) .
Preliminary analysis finds some increased markers.
We are hopeful that we will be able to contribute to help patients with our research.
The above thread from Jonas Begquist - U of Uppsala, Sweden
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