Richard Lewis Profile picture
Jun 9, 2023 9 tweets 3 min read Read on X
This is a totally normal, relatable process, right..? Everyone does this when deciding which fruit to switch to having with their breakfast porridge. To make it palatable. And not cause a 24h delayed crash. 😅 Image
For you (fellow) odd-bods asking for a copy, here you go!:

I've added more/better data to lectins, salicylate and oxalate and made the whole table sortable by any column. I'll add additional fruits on request.🙂docs.google.com/spreadsheets/d…
I really did not expect this casual tweet to pop-off!😅

It was only an overblown aside to my lactate testing thinking. Which hasn't had much interaction, beyond the initial post:

Although I've not finished presenting or considering all my data yet.🤔
@HoagieHoag All my food reactions take about 24h & are kinda vague fatigue, with maybe some gut behaviour differences.

I'm planning to self investigate lactate production from fruit types.

My old IgG food intolerance testing blog, here (scroll down): 2/2lewyland.blogspot.com/2013/09/health…
I found out the *net* fructose (in excess of glucose) is probably the main issue for those with intolerance of it. And updated the sheet to show it:
@4thKennetWitch Also, I'm ADHD-PI/AuDHD with (dyslexic) slow processing speed and executive function difficulty starting tasks that require top-down focus (and sustaining focus), as my main issues.

So maybe quite different to your own experience..? 🙂
@4thKennetWitch But yeah, we have different traits.

Although, I quick feedback and low hanging fruit can *really* help me sustain attention, or be necessary, even in PC games. If that's similar.

And the old time blindness and other stuff.
🔄I've updated the sheet with a bunch more fruit (groan 😅) and a few notes. Hoping not too many copying errors.🤞😬

Good call asking for (sweet?) cherries @chydorina. Maybe an option for me (too): listed low histamine & net fructose. But very high total sugars per unit weight. Image
@neriKdesign @chydorina Or IgE or IgG food (protein) intolerances, for non-bloat (which is pressumably microbial, but I'm totally guessing there).

Can people have issue with organic acids of fruit, like malate, etc..?

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More from @Z3R0Gravitas

Jun 4
1/ Overview of my #MEcfs improvements quantified! #PartialRemission #MEcfsEgress

Context: I've had moderate ME for a decade, gradual onset worsening CFS since teens.

tl;dr - major improvement contributors:
- BornFree minerals (half into stage 1).
- Environmental/mold avoidance. Over 2 years of data. Productivity (left vertical axis) and steps (right vertical axis) graphed together with basic annotations (year starts marked).  Steps shoot up from a nadir of under 1k per day to around 3k at the start of this year, where they've plateaued. From Pedometer, an app on my phone (I take everywhere). My most accurate step count. This is close to my limit, avoiding mild (same-day) PEM.  "Productivity" is (for me) synonymous with having viable cognitive/executive function (my biggest problem) and a lack of physical malaise; I start doing something (semi)useful soon...
2/ More discussion in ALT texts!

Above graph shows most tangible metrics:
• Productivity - almost 2x since pre-Covid1 baseline.
• Step count - up 3x, resuming daily walks (paused a decade).

Down-thread: Improvements in HR rise, FUNCAP, weight... Unroll & blog version at end. Table of contents: - Annotated graph timeline - Pacing not pushing note - Non-24-hour circadian fix - Weight regain - FUNCAP breakdown change - Other improved stats (crash hours, music enjoyment, physical tasks, BMs, gassiness) - Orthostatic intolerance HR & BP rises (POTS/OI). - BornFree protocol, supplements, diet - Mold/environmental avoidance - Personal comments, requests - Tracker sheet overview - Thread reader unroll & blog link
3/ A much more detailed version of the first graph (same 830 day period). I think of my recent history in terms of the landscape of this productivity plot!

More recent improvements dwarf those I made a fuss about in my post-covid analysis threads: I've annotated the starting times of most interventions that I've stuck with, or that had a big temporary effect.  Light blue is "good" and orange "bad". The ones I'm sure were most significant are circled. Some uncircled are likely to have been quietly having a major effect over time (eg B9 - folinic acid).  Major features are: - Two acute covid infections, with the second plunging me very low for a month or two. - The ozone generator disaster, that left me stuck into the spare loft conversion bedroom (with my original causing me flu symptoms and burning parosmia). - St...
Read 34 tweets
Dec 10, 2024
Insights on my new symptoms please!?🙏

Mostly: environmentally triggered sleep transition glitch - something pushes me firmly away from the moment of unconsciousness, etc.

Low on room options, clothes, sanity! Unsure how much is mold/chemicals/dust (& supps). Overwhelmed…
1/n Image
… trying to figure/arrange many things. Awkwardly living, day-sleeping, on my parent's sofa for a month. Worried about losing this refuge.

Any thoughts/questions welcome, even if covered in my kitchen sink information approach, below. (Getting things straight for me too.)
2/n • Details of symptoms: - Reaction - Go to bed fine & sleepy, but instead of (usually quick) nodding off, I get pushed back from that transition. With varying co-symptoms. Or at minimum woken an hour or few later. Overly alert, then very fatigued and miserable later (sleep loss + neurotransmitter swing?).  - Urine production and GI movements sped up 2-3 times right after sleep-glitch (without diarrhoea). Several toilet visits during expected sleep time. - Resting heart rate ramps up (55 -> 70bpm ish). Sustained for a day, declining over a few. But standing up HR is not much higher (than usua...
Full details in ALT texts. In short:
• Sleepy *then* wired after bounce.
• Kidneys & GI overdrive (weight OK).
• Reclined heart rate up ~20bpm.
• Internal vibrations (proportional).
• Lip numbness (brief, slight).
• Overactive then exhausted, miserable.
• Parosmia.
3/n - Internal vibrations. Mild afterwards (electrolyte gradients?). Or in the worse case, briefly intense acutely in chest/neck/head during build up to an unconsciousness rebound (repeatedly). - Sometimes: briefly numb lower lip and/or pre-mouth ulcer lumps pop up a bit in cheeks. (Hypoxia, viral activation?) - Energy and motivation initially up (wired, agitated & snappy at worse) but then fatigued and awful later if no sleep. Some dark/hopeless thoughts. - Weight - lost 1kg over first week (half regained). But often weigh in just as heavy in morning after increased urination. (So sometimes re...
Read 20 tweets
Oct 14, 2024
My notes on @KatBoniface's @RenegadeRes lightning talk. YT vid linked below. Covers:
• #Glutamate (Glu) dysfunction types: excitotoxicity vs hypometabolism.
• Glu transporters (GLAST, GLT-1), aspartate.
• Causes: #TBI, #LC, etc.
• Relation to #ADHD, #autism, not epilepsy.
1/n
Glutamate (Glu) researched for 30 years in #MEcfs & related diseases.

Main focus on excess release = high inter-synaptic levels -> excitotoxicity.

Which causes cell death and hypersensitivity symptoms.
2/n
Glutamate is a key regulator of metabolic & immune functions.

Glu used as fuel by glial brain cells that recycle it for neurons.
3/n
Read 17 tweets
Jul 4, 2024
High level BornFree overview: it's ultra-detailed functional medicine fundamentalism.

• Stage 0: cellular nutrient status assessment - unconventional tests for what's actually in tissue (Oligoscan, CMA, OAT, HTMA).

This modulates a dozen supplement levels, y/n on a few.
1/n
• Stage 1: "remineralisation" is patching up the serious deficiencies we all have, in order from most fundamental/dangerous, like electrolytes up the B-vits trace minerals you've not heard of.

Complex diagrams show where these break/fix key cellular energy, etc, pathways.
2/n
This groundwork supports bodily resilience to weather pathogen die-off, etc:

• Stage 2: beating back biofilms. Primarily in gut, but also importantly nasopharynx, skin, all orifices! Overall burden.

Mostly custom made 'antiseptics', but more probiotics in future.
3/n
Read 25 tweets
Mar 15, 2024
I just made my first ever batch of DrT inspired, Myhill recipe flax/linseed 'buns'. 😀🍞
1/n

Image
Image
Not sure if I cooked them long enough or too long. Still a little moist in the middle, not sure how well they'll keep?

Bland, but not bad tasting. Could do with something on them. Not sure what (given my HIT, etc). Maybe just eat them with my quick stewed dinners.
2/n Image
I tried a mix of golden and brown linseeds (no bigger packs in Sainsbury's app). Don't think it matters much.

Food processor failed to have any effect on them. 😅 But the basic blender managed, thankfully. With some persuasion.
3/n
Image
Image
Read 12 tweets
Mar 7, 2024
Alcohol intolerance in #MEcfs, #LongCovid:

The #ALDH enzymes, that preferentially detoxify ethanol via #acetaldehyde, also degrade histamine! After either DAO (gut) or HNMT then MAO (liver, kidneys).

A major focus of @joshual_tm's BornFree protocol is inadequate ALDH…
1/n 🧵
Crop with my yellow highlights from Joshua Leisk's big metabolism diagram, available here: https://bornfree.life/understanding-the-model/6/updated-disease-model-wip/45/  Shows the two histamine degradation pathways, both requiring ALDH enzymes. Also co-factors of magnesium, zinc, NADH (B3). Before that FAD (B2) and methyl donation from SAMe for HNMT.
… And excess acetaldehyde, from fungus (candida) and gut bacteria. From die-off or just downstream of eating.
2/n HERXHEIMER / DIE-OFF / ACETALDEHYDE SUPPORT  Acetaldehyde is one of the primary toxins released during microbial die-off events and also in smaller amounts, multiple times per day, in response to normal dietary intake of nutrients. Our food intake also feeds our resident microorganisms -including the pathogenic species which allows them to produce (toxic) metabolites and poison us downstream of each meal.
ALDH enzymes are critical to many (!) important processes we #pwME tend to have problems with:

• Synthesis: collagen, carnitine.
• Metabolism: GABA, glycolysis, pyruvate, choline, methylation.
• Degredation: fatty acids.
• Detoxification: vit-A, B6, lysine ethanol...
3/n Acetaldehyde potentially places a difficult  burden on our metabolism in key places -  histamine degradation, neurotransmitter  degradation, collagen synthesis, carnitine  synthesis (needed to transport longer chain fatty  acids), fatty acid degradation, glucose transport  and glycolysis, GABA metabolism, choline  metabolism, methylation, Vitamin B6  degradation, Vitamin A degradation, lysine  degradation, pyruvate metabolism and other  pathways. Aldehyde dehydrogenase enzymes  (ALDH2, 1A1, 1A2, etc) detoxify acetaldehyde  into acetate as a priority over their normal  substrates. Having low...
Read 8 tweets

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