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Richard Lewis Profile picture
@Z3R0Gravitas
Jun 9, 2023 • 9 tweets • 3 min read • Read on X
This is a totally normal, relatable process, right..? Everyone does this when deciding which fruit to switch to having with their breakfast porridge. To make it palatable. And not cause a 24h delayed crash. 😅 Image
For you (fellow) odd-bods asking for a copy, here you go!:

I've added more/better data to lectins, salicylate and oxalate and made the whole table sortable by any column. I'll add additional fruits on request.🙂docs.google.com/spreadsheets/d…
I really did not expect this casual tweet to pop-off!😅

It was only an overblown aside to my lactate testing thinking. Which hasn't had much interaction, beyond the initial post:

Although I've not finished presenting or considering all my data yet.🤔
@HoagieHoag All my food reactions take about 24h & are kinda vague fatigue, with maybe some gut behaviour differences.

I'm planning to self investigate lactate production from fruit types.

My old IgG food intolerance testing blog, here (scroll down): 2/2lewyland.blogspot.com/2013/09/health…
I found out the *net* fructose (in excess of glucose) is probably the main issue for those with intolerance of it. And updated the sheet to show it:
@4thKennetWitch Also, I'm ADHD-PI/AuDHD with (dyslexic) slow processing speed and executive function difficulty starting tasks that require top-down focus (and sustaining focus), as my main issues.

So maybe quite different to your own experience..? 🙂
@4thKennetWitch But yeah, we have different traits.

Although, I quick feedback and low hanging fruit can *really* help me sustain attention, or be necessary, even in PC games. If that's similar.

And the old time blindness and other stuff.
🔄I've updated the sheet with a bunch more fruit (groan 😅) and a few notes. Hoping not too many copying errors.🤞😬

Good call asking for (sweet?) cherries @chydorina. Maybe an option for me (too): listed low histamine & net fructose. But very high total sugars per unit weight. Image
@neriKdesign @chydorina Or IgE or IgG food (protein) intolerances, for non-bloat (which is pressumably microbial, but I'm totally guessing there).

Can people have issue with organic acids of fruit, like malate, etc..?

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More from @Z3R0Gravitas

Richard Lewis Profile picture
Aug 1
1/ IgG (antibodies) food intolerance panel - my first yearly test since major #MEcfs improvements. #MEcfsEgress?

a) Overall far fewer reactions detected than a year ago.
b) Dairy antibodies finally gone after 12 years of exclusions!
c) Reactions again cover suspect foods... Partial screenshot from the first results page of this year's IgG food intolerance screening... Circled in green is milk, where anti-bodies finally fell... Tick in red for egg whites, which have higher antibody reaction that I've seen before, but mostly milder reactions... Most tested substances showing no reaction at all. Making sense as I'd mostly not eaten any of them and those (like salmon) I had shouldn't cause reactions, necessarily. Not if the gut is sound.
2/
 d) But reactions haven't totally taken me out of action the next day (as previous years).
- Eggs: maybe coincided with environmental reactions, too.
- Macadamias : suspect big bag went rancid/moldy and caused mild food poisoning.
- Pineapple: no idea (no fruit mix or enzymes). Page 1 of this years IgG antibody blood test screen. Strong reactions for egg whites, macadamias, sesame (not eaten)... Mild reactions for some foods eaten: coconut, pecans, apricots.... And mild reaction to some definitely not eaten for a long time: cow's milk (beta-lactoglobulin), brazils, chickpeas.
Page 2 of this years IgG antibody blood test screen... Strong reaction to pineapple (not eaten). Not sure if cross-reaction or some testing artifact... Mild reactions to (not eaten): tangerines, avacado.
3/ Last year's results for comparison:

Different layout, with the second page (above) previously spread out over 10 pages, awkwardly. Last years results, showing a wide range of mid-level results for foods I'd mostly not eaten in very many years. A few I had.
Image
Read 14 tweets
Richard Lewis Profile picture
Jul 10
1/ My highlights from the very well run webinar of @PatientLed funded study results on #MEcfs & #LongCovid.

Interesting patient directed funding + colab design. But I've focused more on science titbits. See also @IsabelRamirezRD live-tweeted thread via:
@patientled @IsabelRamirezRD 2/ Braeden Charlton - Long COVID & MEcfs:
- Poor oxygen extraction, earlier lactate (& steeper HR slopes).
- Retain muscle mass vs deconditioning = severe atrophy.
- Poor mitochondrial function vs deconditioning = loss of mitochondria.
- Basement membrane thicker (biomarker?). Presentation slide showing differences between patients, controls and deconditioned subjects.
Presentation slide about upcoming projects. Hints about thicker basement membrane (or muscle tissue) and narrower lumen (of eg mciro-vasculature?) came up as a question afterwards.
@patientled @IsabelRamirezRD 3/ Dr. Caroline Dalton - Microclots:
- Recently infected have my clots than patients without problems.
- Counts normally take ~1 year to fade.
- Only half of LC show high counts (not sensitive marker).
- Meds reduce clots, but often not symptoms.
- Clots indicate inflammation. Image
Read 14 tweets
Richard Lewis Profile picture
Jun 4
1/ Overview of my #MEcfs improvements quantified! #PartialRemission #MEcfsEgress

Context: I've had moderate ME for a decade, gradual onset worsening CFS since teens.

tl;dr - major improvement contributors:
- BornFree minerals (half into stage 1).
- Environmental/mold avoidance. Over 2 years of data. Productivity (left vertical axis) and steps (right vertical axis) graphed together with basic annotations (year starts marked). Steps shoot up from a nadir of under 1k per day to around 3k at the start of this year, where they've plateaued. From Pedometer, an app on my phone (I take everywhere). My most accurate step count. This is close to my limit, avoiding mild (same-day) PEM. "Productivity" is (for me) synonymous with having viable cognitive/executive function (my biggest problem) and a lack of physical malaise; I start doing something (semi)useful soon...
2/ More discussion in ALT texts!

Above graph shows most tangible metrics:
• Productivity - almost 2x since pre-Covid1 baseline.
• Step count - up 3x, resuming daily walks (paused a decade).

Down-thread: Improvements in HR rise, FUNCAP, weight... Unroll & blog version at end. Table of contents: - Annotated graph timeline - Pacing not pushing note - Non-24-hour circadian fix - Weight regain - FUNCAP breakdown change - Other improved stats (crash hours, music enjoyment, physical tasks, BMs, gassiness) - Orthostatic intolerance HR & BP rises (POTS/OI). - BornFree protocol, supplements, diet - Mold/environmental avoidance - Personal comments, requests - Tracker sheet overview - Thread reader unroll & blog link
3/ A much more detailed version of the first graph (same 830 day period). I think of my recent history in terms of the landscape of this productivity plot!

More recent improvements dwarf those I made a fuss about in my post-covid analysis threads: I've annotated the starting times of most interventions that I've stuck with, or that had a big temporary effect. Light blue is "good" and orange "bad". The ones I'm sure were most significant are circled. Some uncircled are likely to have been quietly having a major effect over time (eg B9 - folinic acid). Major features are: - Two acute covid infections, with the second plunging me very low for a month or two. - The ozone generator disaster, that left me stuck into the spare loft conversion bedroom (with my original causing me flu symptoms and burning parosmia). - St...
Read 34 tweets
Richard Lewis Profile picture
Dec 10, 2024
Insights on my new symptoms please!?🙏

Mostly: environmentally triggered sleep transition glitch - something pushes me firmly away from the moment of unconsciousness, etc.

Low on room options, clothes, sanity! Unsure how much is mold/chemicals/dust (& supps). Overwhelmed…
1/n Image
… trying to figure/arrange many things. Awkwardly living, day-sleeping, on my parent's sofa for a month. Worried about losing this refuge.

Any thoughts/questions welcome, even if covered in my kitchen sink information approach, below. (Getting things straight for me too.)
2/n • Details of symptoms: - Reaction - Go to bed fine & sleepy, but instead of (usually quick) nodding off, I get pushed back from that transition. With varying co-symptoms. Or at minimum woken an hour or few later. Overly alert, then very fatigued and miserable later (sleep loss + neurotransmitter swing?). - Urine production and GI movements sped up 2-3 times right after sleep-glitch (without diarrhoea). Several toilet visits during expected sleep time. - Resting heart rate ramps up (55 -> 70bpm ish). Sustained for a day, declining over a few. But standing up HR is not much higher (than usua...
Full details in ALT texts. In short:
• Sleepy *then* wired after bounce.
• Kidneys & GI overdrive (weight OK).
• Reclined heart rate up ~20bpm.
• Internal vibrations (proportional).
• Lip numbness (brief, slight).
• Overactive then exhausted, miserable.
• Parosmia.
3/n - Internal vibrations. Mild afterwards (electrolyte gradients?). Or in the worse case, briefly intense acutely in chest/neck/head during build up to an unconsciousness rebound (repeatedly). - Sometimes: briefly numb lower lip and/or pre-mouth ulcer lumps pop up a bit in cheeks. (Hypoxia, viral activation?) - Energy and motivation initially up (wired, agitated & snappy at worse) but then fatigued and awful later if no sleep. Some dark/hopeless thoughts. - Weight - lost 1kg over first week (half regained). But often weigh in just as heavy in morning after increased urination. (So sometimes re...
Read 20 tweets
Richard Lewis Profile picture
Oct 14, 2024
My notes on @KatBoniface's @RenegadeRes lightning talk. YT vid linked below. Covers:
• #Glutamate (Glu) dysfunction types: excitotoxicity vs hypometabolism.
• Glu transporters (GLAST, GLT-1), aspartate.
• Causes: #TBI, #LC, etc.
• Relation to #ADHD, #autism, not epilepsy.
1/n
Glutamate (Glu) researched for 30 years in #MEcfs & related diseases.

Main focus on excess release = high inter-synaptic levels -> excitotoxicity.

Which causes cell death and hypersensitivity symptoms.
2/n
Glutamate is a key regulator of metabolic & immune functions.

Glu used as fuel by glial brain cells that recycle it for neurons.
3/n
Read 17 tweets
Richard Lewis Profile picture
Jul 4, 2024
High level BornFree overview: it's ultra-detailed functional medicine fundamentalism.

• Stage 0: cellular nutrient status assessment - unconventional tests for what's actually in tissue (Oligoscan, CMA, OAT, HTMA).

This modulates a dozen supplement levels, y/n on a few.
1/n
• Stage 1: "remineralisation" is patching up the serious deficiencies we all have, in order from most fundamental/dangerous, like electrolytes up the B-vits trace minerals you've not heard of.

Complex diagrams show where these break/fix key cellular energy, etc, pathways.
2/n
This groundwork supports bodily resilience to weather pathogen die-off, etc:

• Stage 2: beating back biofilms. Primarily in gut, but also importantly nasopharynx, skin, all orifices! Overall burden.

Mostly custom made 'antiseptics', but more probiotics in future.
3/n
Read 25 tweets

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