Richard Lewis Profile picture
Jun 9, 2023 9 tweets 3 min read Read on X
This is a totally normal, relatable process, right..? Everyone does this when deciding which fruit to switch to having with their breakfast porridge. To make it palatable. And not cause a 24h delayed crash. 😅 Image
For you (fellow) odd-bods asking for a copy, here you go!:

I've added more/better data to lectins, salicylate and oxalate and made the whole table sortable by any column. I'll add additional fruits on request.🙂docs.google.com/spreadsheets/d…
I really did not expect this casual tweet to pop-off!😅

It was only an overblown aside to my lactate testing thinking. Which hasn't had much interaction, beyond the initial post:

Although I've not finished presenting or considering all my data yet.🤔
@HoagieHoag All my food reactions take about 24h & are kinda vague fatigue, with maybe some gut behaviour differences.

I'm planning to self investigate lactate production from fruit types.

My old IgG food intolerance testing blog, here (scroll down): 2/2lewyland.blogspot.com/2013/09/health…
I found out the *net* fructose (in excess of glucose) is probably the main issue for those with intolerance of it. And updated the sheet to show it:
@4thKennetWitch Also, I'm ADHD-PI/AuDHD with (dyslexic) slow processing speed and executive function difficulty starting tasks that require top-down focus (and sustaining focus), as my main issues.

So maybe quite different to your own experience..? 🙂
@4thKennetWitch But yeah, we have different traits.

Although, I quick feedback and low hanging fruit can *really* help me sustain attention, or be necessary, even in PC games. If that's similar.

And the old time blindness and other stuff.
🔄I've updated the sheet with a bunch more fruit (groan 😅) and a few notes. Hoping not too many copying errors.🤞😬

Good call asking for (sweet?) cherries @chydorina. Maybe an option for me (too): listed low histamine & net fructose. But very high total sugars per unit weight. Image
@neriKdesign @chydorina Or IgE or IgG food (protein) intolerances, for non-bloat (which is pressumably microbial, but I'm totally guessing there).

Can people have issue with organic acids of fruit, like malate, etc..?

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More from @Z3R0Gravitas

Oct 14
My notes on @KatBoniface's @RenegadeRes lightning talk. YT vid linked below. Covers:
• #Glutamate (Glu) dysfunction types: excitotoxicity vs hypometabolism.
• Glu transporters (GLAST, GLT-1), aspartate.
• Causes: #TBI, #LC, etc.
• Relation to #ADHD, #autism, not epilepsy.
1/n
Glutamate (Glu) researched for 30 years in #MEcfs & related diseases.

Main focus on excess release = high inter-synaptic levels -> excitotoxicity.

Which causes cell death and hypersensitivity symptoms.
2/n
Glutamate is a key regulator of metabolic & immune functions.

Glu used as fuel by glial brain cells that recycle it for neurons.
3/n
Read 17 tweets
Jul 4
High level BornFree overview: it's ultra-detailed functional medicine fundamentalism.

• Stage 0: cellular nutrient status assessment - unconventional tests for what's actually in tissue (Oligoscan, CMA, OAT, HTMA).

This modulates a dozen supplement levels, y/n on a few.
1/n
• Stage 1: "remineralisation" is patching up the serious deficiencies we all have, in order from most fundamental/dangerous, like electrolytes up the B-vits trace minerals you've not heard of.

Complex diagrams show where these break/fix key cellular energy, etc, pathways.
2/n
This groundwork supports bodily resilience to weather pathogen die-off, etc:

• Stage 2: beating back biofilms. Primarily in gut, but also importantly nasopharynx, skin, all orifices! Overall burden.

Mostly custom made 'antiseptics', but more probiotics in future.
3/n
Read 25 tweets
Mar 15
I just made my first ever batch of DrT inspired, Myhill recipe flax/linseed 'buns'. 😀🍞
1/n

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Not sure if I cooked them long enough or too long. Still a little moist in the middle, not sure how well they'll keep?

Bland, but not bad tasting. Could do with something on them. Not sure what (given my HIT, etc). Maybe just eat them with my quick stewed dinners.
2/n Image
I tried a mix of golden and brown linseeds (no bigger packs in Sainsbury's app). Don't think it matters much.

Food processor failed to have any effect on them. 😅 But the basic blender managed, thankfully. With some persuasion.
3/n
Image
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Read 12 tweets
Mar 7
Alcohol intolerance in #MEcfs, #LongCovid:

The #ALDH enzymes, that preferentially detoxify ethanol via #acetaldehyde, also degrade histamine! After either DAO (gut) or HNMT then MAO (liver, kidneys).

A major focus of @joshual_tm's BornFree protocol is inadequate ALDH…
1/n 🧵
Crop with my yellow highlights from Joshua Leisk's big metabolism diagram, available here: https://bornfree.life/understanding-the-model/6/updated-disease-model-wip/45/  Shows the two histamine degradation pathways, both requiring ALDH enzymes. Also co-factors of magnesium, zinc, NADH (B3). Before that FAD (B2) and methyl donation from SAMe for HNMT.
… And excess acetaldehyde, from fungus (candida) and gut bacteria. From die-off or just downstream of eating.
2/n HERXHEIMER / DIE-OFF / ACETALDEHYDE SUPPORT  Acetaldehyde is one of the primary toxins released during microbial die-off events and also in smaller amounts, multiple times per day, in response to normal dietary intake of nutrients. Our food intake also feeds our resident microorganisms -including the pathogenic species which allows them to produce (toxic) metabolites and poison us downstream of each meal.
ALDH enzymes are critical to many (!) important processes we #pwME tend to have problems with:

• Synthesis: collagen, carnitine.
• Metabolism: GABA, glycolysis, pyruvate, choline, methylation.
• Degredation: fatty acids.
• Detoxification: vit-A, B6, lysine ethanol...
3/n Acetaldehyde potentially places a difficult  burden on our metabolism in key places -  histamine degradation, neurotransmitter  degradation, collagen synthesis, carnitine  synthesis (needed to transport longer chain fatty  acids), fatty acid degradation, glucose transport  and glycolysis, GABA metabolism, choline  metabolism, methylation, Vitamin B6  degradation, Vitamin A degradation, lysine  degradation, pyruvate metabolism and other  pathways. Aldehyde dehydrogenase enzymes  (ALDH2, 1A1, 1A2, etc) detoxify acetaldehyde  into acetate as a priority over their normal  substrates. Having low...
Read 8 tweets
Mar 6
My collection since end of 2023.😜

OK, so I only use the Omron BP cuff for get-up readings, but the other 3 (Fitbit, Garmin, Visible) I've continued with, for different metrics.

Possibly a little 'extra', with all the graph posting?😳 But I draw the line at Oura Ring!
1/n 🧵?
Image
So what is each best at? 🤔

1️⃣ Fitbit Luxe (£90, no sub):

✅ Tiny. Sleep structure more believable. Daily RHR is my longest running metric.

❌ App inflexibility. Only 5 day battery. My #non24 causes HRV nonsense data & missed sleeps. Peak HR missed:
2/n
2️⃣ Visible Plus (£50 + £15/mth):

✅ HR accuracy matches pulse oximeter:

Great for #MEcfs pacing even with #POTS HR spikes. Tagging system. Most comfy. Enthusiastic #pwME devs.

❌ Expensive for feature set & hardware. <20h batt. No sleep tracking.
3/n
Read 8 tweets
Jan 12
The weirdness of my illness is so isolating. 😕

It was a relief, in 2013, to go from an n=1 "illness CV" to #MEcfs.

But currently I feel like I'd need a dissertation to adequately explain the context of any problem, even when asking this community. Like...
1/n
A minor one: what meal do I have now?! And which set of supplements? 😵‍💫

¼ tab Cetirizine turned my sleep from ~6h to 11h+2h nap.

Then ⅛ to 2.5h+5h nap (in rest between dinner servings).

Now after stopping I've had 0 hours...
2/n Garmin Vivosmart 5 "Sleep Consistency" graph for for last 2 weeks.
I lay here (gently vibrating) in the blacked out spare bedroom; #non24 means I naturally sleep later each day.

I consider if *this time* it's my body spontaneously entraining to daylight hours..? 🤔

It never is. 🙄
3/n
Read 44 tweets

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