My notes on @KatBoniface's @RenegadeRes lightning talk. YT vid linked below. Covers:
• #Glutamate (Glu) dysfunction types: excitotoxicity vs hypometabolism.
• Glu transporters (GLAST, GLT-1), aspartate.
• Causes: #TBI, #LC, etc.
• Relation to #ADHD, #autism, not epilepsy.
1/n

https://twitter.com/KatBoniface/status/1831771372370182323

Glutamate (Glu) researched for 30 years in #MEcfs & related diseases.

Main focus on excess release = high inter-synaptic levels -> excitotoxicity.

Which causes cell death and hypersensitivity symptoms.
2/n

High level BornFree overview: it's ultra-detailed functional medicine fundamentalism.

• Stage 0: cellular nutrient status assessment - unconventional tests for what's actually in tissue (Oligoscan, CMA, OAT, HTMA).

This modulates a dozen supplement levels, y/n on a few.
1/n

https://twitter.com/hiimjakekthx/status/1808851603132190985

• Stage 1: "remineralisation" is patching up the serious deficiencies we all have, in order from most fundamental/dangerous, like electrolytes up the B-vits trace minerals you've not heard of.

Complex diagrams show where these break/fix key cellular energy, etc, pathways.
2/n

I just made my first ever batch of DrT inspired, Myhill recipe flax/linseed 'buns'. 😀🍞
1/n

https://twitter.com/chydorina/status/1766589747114230147

Not sure if I cooked them long enough or too long. Still a little moist in the middle, not sure how well they'll keep?

Bland, but not bad tasting. Could do with something on them. Not sure what (given my HIT, etc). Maybe just eat them with my quick stewed dinners.
2/n

Alcohol intolerance in #MEcfs, #LongCovid:

The #ALDH enzymes, that preferentially detoxify ethanol via #acetaldehyde, also degrade histamine! After either DAO (gut) or HNMT then MAO (liver, kidneys).

A major focus of @joshual_tm's BornFree protocol is inadequate ALDH…
1/n 🧵

https://twitter.com/laurenancona/status/1765127843158049231

… And excess acetaldehyde, from fungus (candida) and gut bacteria. From die-off or just downstream of eating.
2/n

My collection since end of 2023.😜

OK, so I only use the Omron BP cuff for get-up readings, but the other 3 (Fitbit, Garmin, Visible) I've continued with, for different metrics.

Possibly a little 'extra', with all the graph posting?😳 But I draw the line at Oura Ring!
1/n 🧵?

https://twitter.com/hiimjakekthx/status/1765248169502257620

So what is each best at? 🤔

1️⃣ Fitbit Luxe (£90, no sub):

✅ Tiny. Sleep structure more believable. Daily RHR is my longest running metric.

❌ App inflexibility. Only 5 day battery. My #non24 causes HRV nonsense data & missed sleeps. Peak HR missed:
2/n

https://twitter.com/Z3R0Gravitas/status/1677553289217318912?t=OHp4JqNaqjiOxyNUASqLsg&s=19

The weirdness of my illness is so isolating. 😕

It was a relief, in 2013, to go from an n=1 "illness CV" to #MEcfs.

But currently I feel like I'd need a dissertation to adequately explain the context of any problem, even when asking this community. Like...
1/n A minor one: what meal do I have now?! And which set of supplements? 😵‍💫

¼ tab Cetirizine turned my sleep from ~6h to 11h+2h nap.

Then ⅛ to 2.5h+5h nap (in rest between dinner servings).

Now after stopping I've had 0 hours...
2/n

Another paper that correlates with my decade old metabolic test results, with #MEcfs! 😅

I guess also vindicates my continued taking of 5-HTP.🤔

They found reduced peripheral serotonin (in blood rather than CNS). Via meta-analysis and targeted #LongCovid patient testing.
🧵 1/n

https://twitter.com/MaayanLevy_Lab/status/1713929997155811789

Functional medicine testing in 2013 showed I had almost all low serum amino acids, including tryptophan, etc.

2014 study then suggested they're used for cellular energy. I thought this produces the high aspartate (I saw) as a byproduct. But does new paper show that low, too?
2/n

I was lucky enough to be offered @visible_health's VisiblePlus+ early access program, for better monitoring #LongCovid #MEcfs #POTS.

Here's what I know:
• Polar Verity Sense arm band.
• UK only initially, US next.
• £65 buy in includes 1 month subscription at £15.
🧵 1/n Harry's introductory video gives an overview of the new service:
• High accuracy HR data all day (not in sleep).
• Better morning stability readings.
• Real time alerts.
• Pace points to budget activity.
• In development: UpTime & OI HR changes.
2/n

Why did I have a temporary post-Covid #MEcfs *improvement*..?!🤔

I've tried to figure it out by assembling this Google Sheets self-tracking #dataVis extravaganza.😵‍💫

I'll try to break it down into more manageable parts and explain the various ideas I've brainstormed.🙂
🧵 1/n To be clear, this quantifiable step up in my function is what I mean.

Luckily, I discovered I'd left a Pedometer android app running for the last 2 years, giving objective data pre-Fitbit.

Which apparently validates my somewhat subjective daily "productivity" scores.😃
2/n

This is a totally normal, relatable process, right..? Everyone does this when deciding which fruit to switch to having with their breakfast porridge. To make it palatable. And not cause a 24h delayed crash. 😅 For you (fellow) odd-bods asking for a copy, here you go!:

I've added more/better data to lectins, salicylate and oxalate and made the whole table sortable by any column. I'll add additional fruits on request.🙂docs.google.com/spreadsheets/d…